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Nov. 15, 2007 -- Most dieters who take prescription weight loss medications lose only a fraction of the weight they want to lose, and many don't stick with the drugs, a review of the research shows.
When results from 30 trials were analyzed, long-term users of three widely prescribed weight loss drugs lost an average of 6 to 11 pounds over the course of one to four years.
Between 30% and 40% of the participants stopped taking the drugs before the trials ended.
Users of the drugs Xenical, Meridia, and the unapproved drug Acomplia did lose more weight than dieters who took placebos.
They were also more likely to lose 5% to 10% of their body weight -- an amount that is recognized for reducing the severity of obesity-related risks such as? diabetes, heart disease, and other weight-related health problems.
But Raj Padwal, MD, of the University of Alberta, says most people who take weight loss drugs are hoping to lose much more weight than the studies suggest they do.
"People tend to be disappointed with the degree of weight loss they achieve with these drugs, even when they know that modest weight loss will improve their health," he says. "People who are desperate to lose weight are usually willing to try drugs, but if they don't see the results they want in two or three months they don't tend to stay on them."