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降钙素基因相关肽与脑血管病

来源:解剖科学进展
摘要:摘要:降钙素基因相关肽(CGRP)是人类利用基因重组技术发现的第一个活性多肽,具有多种生理功能,其药理作用已受到广泛重视。Effectofcalcitoningene-relatedpeptideinpatientswithdelayedpostoperativecerebralischemiaafteraneurysmalsubarachnoidhaemorrhage。Lancet,1992,339:831[3]TerradoJ,......

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  摘 要:降钙素基因相关肽(CGRP)是人类利用基因重组技术发现的第一个活性多肽,具有多种生理功能,其药理作用已受到广泛重视。本文就CGRP在神经系统的分布、扩血管作用、神经保护作用及其与部分脑血管病的关系方面进行了综述。 参考文献:

  [1]王尧,杜子威主编.神经生物化学与分子生物学.第1版.北京,人民卫生出版社,1997, 181

  [2]European CGRP in SAH Study Group. Effect of calcitoningene-related peptide in patients with delayed postoperative cerebral ischemia after aneurysmal subarachnoid haemorrhage. Lancet, 1992, 339: 831

  [3]Terrado J, Gerrikagoitia I,Dominguez L et al. Expression of the gene for alpha-type and beta-type calcitonin gene-related peptide during rat embrogenesis. Neuroscience, 1999, 92(2): 713

  [4]张万江,盛树力.降钙素基因相关肽研究进展.首都医学院学报,1990, 11(4): 314

  [5]Nasu F. Analysis of calcitonin gene-related peptide(CGRP)-containing nerve fibres in the rat spinal cord using light and electron microscopy. J Electron microsc(Tokyo),1999, 48(3): 267

  [6]Conti F, De Biasi S, Minelli A et al. Clcitonin gene-related peptide (CGRP) in the cat neocortex; evidence for a sparse but widespread network of immunoreactive fibers. Cereb Cortex, 1994, 4(1): 97

  [7]Freund TF, Hajos N, Acsady L, et al. Mossy cells of the rat dentate gyrus are immunoreactive for calcitonin gene-related peptide(CGRP). Eur J Neurosci, 1997, 9(9): 1815

  [8]Yasui Y, Saper CB, Cechetto DF. Calcitonin gene-related peptide immunoreactivity in the visceral sensory cortex, thalamus, and related pathways in the rat. J Comp neurol, 1989, 22; 290(4): 487

  [9]Holland JP, Sydserff SG. C, Taylor WA. S, et al. Calcitonin gene-related peptide reduces brain injury in a rat model of focal cerebral ischemia. Stroke, 1994, 25: 2055

  [10]Peltier AC, Bishop GA. The site of origin of calcitonin gene-related peptide-like immunoreactive afferents to the inferior olovary complex of the mouse. Neurosci res, 1999, 34(3): 177

  [11]Fodor M, Pammer C, Gorcs T, et al. Neuropeptides in the human dorsal vagal complex: an immunohistochemical study. J Chem neuroanat, 1994, 7(3): 141

  [12]Edvinsson L, Delgado-Zygmunt T, Ekman R, et al. Involvement of perivascular sensory fibers in the pathophysiology of cerebral vasospasm following subarachnoid hemorrhage. J Cereb Blood Flow metab, 1990, 10: 602

  [13]Tsai SH, Tew JM, Mclean JH, et al. Cerebral arterial innervation by nerve fibers containing calcitonin gene-related peptide(CGRP):I. Distribution and origin of CGRP perivacular innerration in the rat. J Comp neurol, 1988, 15; 271(3): 435

  [14]Ando K. Innervation of two peptidergic (substance P and calcitonin gene-related peptide) nerves in the cerebral arteries and choroid piexus of the Japanese Newt(Triturus pyrrhogaster). J Vet Med Sci, 1997, 59(11): 971

  [15]Wimalawansa SJ, el-Kholy AA. Comparative study of distribution and biochemical characterization of brain calcitonin gene-related peptide receptors in five different species. Neuroscience, 1993, 54(2): 513

  [16]Ye Z, Wimalawansa SJ, Weatlund KN. Receptor for calcitonin gene-related peptide: localization in the dorsal and ventral spinal cord. Neuroscience, 1999, 92(4): 1389

  [17]Johnston FG, Bell BA, Robertson IJ, et al. Effect of calcitonin gene-related peptide on postoperative neurological deficits after subarachnoid haemorrhage. Lancet, 1990, 335: 869

  [18]Edvinsson L, Ekman R, Jansen I et al. Calcitonin gene-related peptide and cerebral blood vessels: ditribution and vasomotor effects. J Cereb Blood Flow metab, 1987, 7(6): 720

  [19]You J, Gulbenkian S, Jansen Olesen I, et al. Peptidergic innervation of guinea-pig brian vessels:comparison with immunohistochemistry and in vitro pharmacology in rostrally and caudally located arteries. J Auton Nerv syst, 1995, 55(3): 179

作者: 花放方秀斌 2004-9-30
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