摘要：【摘要】 Ureagenesis in the liver consumes up to 1,000 mmol of /day in humans as a result of + urea + CO 2 + 3H 2 O。 Whether the liver contributes to the regulation of acid-base equilibrium b...

摘要：Recently, we cloned sodium dicarboxylate cotransporter-3 from winter flounder kidney (fNaDC-3)。The Na + -dicarboxylate cotransporters of the NaDC-3 subfamily have been cloned from rat kidney [SDCT...

摘要：【摘要】 At the onset of diabetes mellitus, the glomerular filtration rate becomes supranormal。 Discovery science has identified many abnormalities in the early diabetic kidney that apparentl...

摘要：【摘要】 Endothelin-1 (ET-1) is a powerful vasoconstricting peptide。 Recent studies showed synthesis of ET-1 and the presence of ET receptors in urinary bladder smooth muscle cells。 In the p...

摘要：【摘要】 2,3-Dimercapto-1-propanesulfonic acid (DMPS) is used clinically to increase urinary excretion of heavy metals, including mercury and arsenic。 We used single S2 segments and suspensio...

摘要：【摘要】 In tests of osmotic tolerance of renal inner medullary cells in tissue culture, osmolality has usually been increased in a single step, whereas in vivo the increase occurs gradually o...

摘要：【摘要】 We investigated the effects of pravastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, on interstitial inflammation and fibrosis, using an a...

摘要：【摘要】 Digital three-dimensional (3-D) functional reconstructions of inner medullary nephrons were performed。 Antibodies against aquaporins (AQP)-1 and -2 and the chloride channel ClC-K1 id...

摘要：【摘要】 The renal collecting duct plays a key role in control of ion and fluid homeostasis。 Genes encoding for ion transporters, hormone receptors, or regulatory proteins specifically expres...

摘要：An apical V-type H + -ATPase and a basolateral exchanger, located in intercalated cells of OMCD, mediate the bicarbonate reabsorption。 Here we report the identification of a new basolateral exchan...

摘要：This screening demonstrated expression of a protein kinase consistent with SK2, a group II germinal center kinase and homolog of human Ste20-like kinase (SLK)。 SK2 mRNA, protein expression, and ki...

摘要：The purposes of this study were 1 ) to quantify accumulation of SF in normal and cystic rat kidneys in vivo and 2 ) to test whether SF accumulation could be used as a marker for cysts derived from ...

摘要：【摘要】 Diabetic nephropathy is now the leading cause of end-stage renal diseases, and glomerular sclerotic injury is an initial event that provokes renal dysfunction during processes of diab...

摘要：【摘要】 Glucose uptake is increased in hypertension。 Thus we investigated Na + -glucose cotransporter (SGLT2) activity and expression in proximal tubules from renovascular hypertensive rats。...

摘要：【摘要】 We investigated the expression of ERK, p38 mitogen-activated protein kinase (p38), and JNK in renal tubules of diabetic rats following 3 wk after streptozotocin injection (DM)。 Altho...

摘要：【摘要】 Local anesthetics are widely used during the perioperative period, even in patients with preexisting renal disease。 We questioned whether local anesthetics potentiate renal dysfuncti...

摘要：【摘要】 Troglitazone was studied in pH-sensitive LLC-PK 1 -F + cells to determine the effect on pH i and glutamine metabolism as well as the role of peroxisome proliferator-activated receptor...

摘要：【摘要】 Recent advances in our understanding of the developmental biology of the kidney, as well as the establishment of novel in vitro model systems, have potential implications for kidney t...