摘要：【摘要】 Two nonradioactive methods for determining glomerular filtration rate (GFR) in conscious mice using FITC-labeled inulin (FITC-inulin) were evaluated。l/min in male and female C57BL/6J...

摘要：【摘要】 Hepatocyte growth factor (HGF) induces migration, proliferation, and branching in renal epithelial cells from the inner medullary collecting duct (mIMCD-3 cells)。 Microarray analysis...

摘要：【摘要】 Previous studies demonstrated that during cisplatin-induced acute renal failure, there is a significant reduction in proximal tubule fatty acid oxidation。 We now report on the effect...

摘要：【摘要】 Previous Northern blot studies suggested strong expression of a homolog to the sodium-dependent hepatocellular methotrexate transporter in the kidneys。 Here, we report on the cloning...

摘要：Although biomarkers for nephrotoxicity are available, they often lack sensitivity and are not specific as indicators of epithelial cell injury。 Kidney injury molecule-1 (Kim-1) is a type 1 membran...

摘要：【摘要】 The purpose of this study was to evaluate whether the natriuresis and polyuria seen in parathyroid hormone (PTH)-induced hypercalcemia are associated with dysregulation of renal Na tr...

摘要：This consideration has provided the rationale for studies in subtotally nephrectomized rats showing that 1,25(OH) 2 D 3 interferred with glomerulosclerosis。 It was the purpose of the present study...

摘要：【摘要】 Angiotensin II mediates the progression of renal disease through the type 1 receptor (AT 1 R)。 Recent studies have suggested that type 2 receptor (AT 2 R)-mediated signaling inhibits...

摘要：【摘要】 Interactions between transforming growth factor- (TGF- ) and nitric oxide (NO) are important in the pathophysiology of unilateral ureteral obstruction (UUO)。 Dopamine (DA) is a vasoa...

摘要：Previously, we reported that these signals stimulate branched-chain amino acid (BCAA) oxidation in renal tubule cells by increasing both the amount and activation state of branched-chain -ketoacid ...

摘要：【摘要】 We evaluated the glomerular filtration rate (GFR) during the second postpartum week in 22 healthy women who had completed an uncomplicated pregnancy。 We used physiological techniques...

摘要：Loss-of-function mutations in the K channel, ROMK (Kir1。 ROMK(-/-) null mice exhibit a Bartter phenotype and lack the small-conductance (30-pS) apical K channel (SK) in the TAL。 However, a distin...

摘要：【摘要】 To unravel the molecular regulation of renal transcellular Ca 2+ transport, a murine distal convoluted tubule (mpkDCT) cell line derived from distal convoluted tubules (DCT) microdiss...

摘要：【摘要】 Proximal straight tubules (PST) from both neonatal and hypothyroid adult rabbits have a lower rate of passive volume absorption when perfused with a high-chloride solution simulating ...

摘要：Assembly of C5b-9 increases cytosolic Ca 2+ concentration and results in transactivation of receptor tyrosine kinases and activation of PLC- 1 and the 1,2-diacylglycerol (DAG)-PKC pathway。 This st...

摘要：【摘要】 Retinoids reduce renal damage in rat experimental glomerulonephritis。 It is unknown, however, how local and systemic retinoid pathways respond to renal injury。 We examined the extra...

摘要：【摘要】 Dopamine, via activation of renal D 1 receptors, inhibits the activities of Na-K-ATPase and Na/H exchanger and subsequently increases sodium excretion。 Decreased renal dopamine produ...

摘要：【摘要】 Microalbuminuria is a marker for diabetic nephropathy。 It also signifies cardiovascular disease, as well as nephropathy, in type 2 diabetes (DM2)。 Microalbuminuria may precede DM2, ...

摘要：【摘要】 Heme oxygenases (HOs) catalyze the rate-limiting step in heme degradation, resulting in the formation of iron, carbon monoxide, and biliverdin, the latter of which is subsequently con...