摘要：【摘要】 Bid is a proapoptotic Bcl-2 family protein, which on activation translocates to mitochondria and induces damage to the organelles。 Activation of Bid depends on its proteolytic proces...

摘要：【摘要】 The adhesion of uropathogenic Escherichia coli to the urothelial surface of the bladder is a prerequisite for the establishment of bladder infections。 In this study, we examined the ...

摘要：【摘要】 In ischemic or hypoxic tissues, elevated Ca 2+ levels have emerged as one of the main damaging agents among other Ca 2+ -independent mechanisms of cellular injury。 Because mitochondr...

摘要：【摘要】 We recently showed that, in a proximal tubule cell line (opossum kidney cells), epithelial growth factor (EGF) stimulates basolateral organic anion transport (OAT) via ERK1/2, arachid...

摘要：【摘要】 Despite production by podocytes of the proangiogenic molecule vascular endothelial growth factor-A (VEGF), the glomeruli are not sites of angiogenesis。 We recently described mRNA exp...

摘要：【摘要】 In rats with streptozotocin-induced diabetes mellitus for 10-20 days, we showed that the abundance of the major medullary transport proteins involved in the urinary concentrating mech...

摘要：【摘要】 Mutations in the PHEX gene are responsible for X-linked hypophosphatemia, a renal phosphate-wasting disorder associated with defective skeletal mineralization。 PHEX is predominantly ...

摘要：Epoxyeicosatrienoic acids are converted by soluble epoxide hydrolase into the corresponding dihydroxyeicosatrienoic acids, and epoxyeicosatrienoic acid hydration is regarded as one mechanism whereb...

摘要：【摘要】 The role of caveolae in CD40/CD154 activation of proinflammatory chemokines and their potential role in renal inflammatory disease were explored in primary cultures of human renal pro...

摘要：【摘要】 Hepatocyte growth factor (HGF) elicits a broad spectrum of biological activities, including epithelial cell dedifferentiation。 One of the most widely used and best-studied polarized ...

摘要：However, vasoactive hormones, such as prostaglandin E 2 (PGE 2 ), may challenge the integrity of the actin cytoskeleton, alter podocyte morphology, and compromise glomerular permeability。 We inves...

摘要：【摘要】 Disruption of the major renal Na-phosphate (P i ) cotransporter gene Npt2a in mice leads to a substantial decrease in renal brush-border membrane Na-P i cotransport, hypophosphatemia,...

摘要：【摘要】 The vascular actions of endothelin-1 (ET-1) reflect the combination of vasoconstrictor ET A and ET B receptors on smooth muscle cells and vasodilator ET B receptors on endothelial cel...

摘要：We previously reported that hyperglycemia augments both ANG II-induced growth and activation of Janus kinase (JAK)2 and signal transducers and activators of transcription (STAT) proteins in culture...

摘要：【摘要】 Regulation of phosphate (P i ) reabsorption occurs through the up- and downregulation of the renal type-II sodium P i cotransporters (NaPi-2)。 Recently, renal NaPi2-type expression h...

摘要：【摘要】 Close-arterial infusion of test substances allows one to study the responses of a selected vascular bed without inducing confounding systemic effects。 Unfortunately, laminar flow pat...

摘要：【摘要】 ANG II and Na + -glucose cotransporter have been reported to be associated with the onset of diverse renal diseases。 However, the effect of ANG II on Na + -glucose cotransporter acti...

摘要：【摘要】 Signaling by the transforming growth factor (TGF)- superfamily is important during kidney development。 Here, we describe the spatial and temporal expression patterns of the Smads, th...

摘要：【摘要】 Recent evidence indicates that interstitial infiltration of T cells and macrophages plays a role in the pathogenesis of salt-sensitive hypertension。 The present review examines this ...

摘要：Magnesium transport in this part of the nephron is active and transcellular in nature ( Fig。 Physiological studies indicate that apical entry into DCT cells is mediated by a specific and regulated...