摘要：【摘要】 Aldosterone enhances Na + reabsorption via epithelial Na + channels (ENaC)。 Aldosterone also stimulates the protein kinase ERK1/2- and the epidermal growth factor (EGF) receptor (EGF...

摘要：【摘要】 We studied the effects of two mutations of the extracellular loop of the -subunit of the (ENaC) on amiloride-sensitive current in Xenopus laevis oocytes and the inhibition of this cur...

摘要：【摘要】 Ischemic acute renal failure involves not only the kidney but also extrarenal organs such as the bone marrow that produces inflammatory cells。 By ELISA and RNase protection assays, w...

摘要：【摘要】 Primary aldosteronism causes severe hypertension in humans (Conn‘s syndrome) with cardiac hypertrophy, characterized by a fibrosis more severe than the one observed in patients with ...

摘要：The aim of this study was to further characterize tubular developmental deficits in neonatal rats, focusing on the thick ascending limb of Henle (TALH), known to undergo profound developmental chan...

摘要：PBX-binding site at -60 bp have been demonstrated to be critical to expression of the mouse renin gene ( Ren-1 c ) in As4。 In this report, we show that a region (-197 to -70) immediately 5‘ to th...

摘要：【摘要】 Amiloride-sensitive epithelial Na + channels (ENaCs) are subject to modulation by many factors。 Recent data have also linked the N -ethylmaleimide-sensitive factor attachment protein...

摘要：【摘要】 We have used Western blot analysis and immunocytochemistry to determine the effect of dietary K intake on the expression of protein kinase C (PKC) isoforms in the kidney。 Western blo...

摘要：To determine the nephron segment localization of claudin-7 and -8, immunofluorescence staining of mouse kidney sections was performed using isoform-specific antibodies。 Claudin-8 was found to be e...

摘要：【摘要】 Aldosterone participates in the pathophysiology of several models of progressive chronic renal disease。 Because of the causal connection between transforming growth factor- 1 (TGF- )...

摘要：【摘要】 One component of the macula densa (MD) tubuloglomerular feedback (TGF) signaling pathway may involve basolateral release of ATP through a maxi-anion channel。 Release of ATP has previ...

摘要：【摘要】 Increased intrarenal renin-angiotensin system activity contributes to diabetic nephropathy。 ANG II generation in mesangial cells (MC) is increased by high-glucose (HG) exposure。 Thi...

摘要：The effect of catalase deficiency on renal tubulointerstitial injury induced by unilateral ureteral obstruction (UUO) has been studied in homozygous acatalasemic mutant mice (C3H/AnLCs b Cs b ) com...

摘要：ADPKD is caused by mutations in the PKD1 and PKD2 genes, encoding the transmembrane proteins polycystin-1 (PC1) and polycystin-2 (PC2), respectively。 The PC2 channel is implicated in the transient...

摘要：【摘要】 The calcium-sensing receptor (CaSR) represents the molecular mechanism by which parathyroid cells detect changes in blood ionized calcium concentration and modulate parathyroid hormon...