摘要：【摘要】 Although the regulation of cyclooxygenase-2 (COX-2) expression in the kidney cortex has been extensively characterized, the physiological control mechanisms of COX-2 expression at the...

摘要：Several studies have documented downregulation of lipoprotein lipase, hepatic triglyceride lipase, and the VLDL receptor, leading to depressed clearance and elevated plasma concentration of triglyc...

摘要：【摘要】 The Wistar-Furth (WF) rat is protected against chronic renal disease (CRD) following 5/6th ablation/infarction vs。 the Sprague-Dawley (SD) rat, and protection was associated with pre...

摘要：【摘要】 The intrarenal autocrine-paracrine dopamine (DA) system is critical for Na + homeostasis。 L -Dihydroxyphenylalanine ( L -DOPA) uptake from the glomerular filtrate and plasma provides...

摘要：【摘要】 Hepatocyte growth factor (HGF) is a pleiotropic factor that plays an imperative role in tubular repair and regeneration after acute renal injury。 Growing evidence indicates that HGF ...

摘要：【摘要】 Previously, we showed that physiological functions of renal proximal tubular cells (RPTC) do not recover following S -(1,2-dichlorovinyl)- L -cysteine (DCVC)-induced injury。 This stu...

摘要：【摘要】 Absorption of HCO 3 - in the medullary thick ascending limb (MTAL) is mediated by apical membrane Na + /H + exchange。 The identity and function of other apical acid-base transporters...

摘要：【摘要】 Hyperhosphatemia and secondary hyperparathyroidism are common and severe complications of chronic renal failure。 Therapies to reduce serum phosphate have been shown to reduce serum p...

摘要：【摘要】 Recent studies suggest that vitamin D may play a role in intestinal Na + -dependent phosphate transport adaptation to variable levels of dietary P i。 Therefore, the goal of the curre...

摘要：【摘要】 In killifish renal proximal tubules, endothelin-1 (ET-1), acting through a basolateral ET B receptor, nitric oxide synthase (NOS), and PKC, decreases cell-to-lumen organic anion trans...

摘要：8-fold increase in low-density lipoprotein receptor-1 (LOX-1) expression。 LOX-1 is a major endothelial receptor for oxidized low-density lipoproteins (OxLDL) and is assumed to play a role in the i...

摘要：【摘要】 TRPV4, a nonselective cation channel of the transient receptor potential (TRP) family, is gated by hypotonicity。 Expression of TRPV4 mRNA has been detected in the circumventricular o...

摘要：【摘要】 Nociceptin, the endogenous ligand of the inhibitory G protein-coupled opioid receptor-like 1 receptor, produces aquaresis (i。 Using immunohistochemistry, we found the opioid receptor...

摘要：【摘要】 The aim of this study was to evaluate the long-term effects of cyclosporine (CsA) treatment on urinary concentration ability。 Long-term CsA treatment increased urine volume and fract...

摘要：The role of the major renal PAH transporters, OAT1 and OAT3, in the generation of these gender differences, as well as the responsible hormones and mechanisms, has not been clarified。 Here we used...

摘要：【摘要】 Growth hormone (GH) is an important factor in the developmental adaptation to enhance P i reabsorption。 Micropuncture experiments were performed after acute thyroparathyroidectomy in...

摘要：【摘要】 In essential hypertension, the defect in renal dopamine (DA) D 1 receptor function is intrinsic to proximal tubules as this phenomenon is also seen in primary proximal tubule cultures...

摘要：【摘要】 Although mammalian urothelia are generally considered impermeable to urinary constituents, in vivo studies in several species suggest urothelial transport of water, urea, and solutes ...