摘要:This study examined the role of estrogen receptor (ER )-mediated events in normal and diabetic renal and glomerular growth。 Body weight, kidney weight, glucose, insulin, renal transforming growth ...
08-07-04摘要:【摘要】 Mammalian gastrin-releasing peptide (GRP) has a widespread distribution and multiple stimulating effects on metabolism, release of regulatory peptides, gastrointestinal and pancreatic...
08-07-04摘要:【摘要】 The mammalian kidney bumetanide-sensitive Na + -K + -2Cl - and thiazide-sensitive Na + -Cl - cotransporters are the major pathways for salt reabsorption in the thick ascending limb of...
08-07-04摘要:【摘要】 One function of the vertebrate choroid plexus (CP) is removal of potentially toxic metabolites and xenobiotics from cerebrospinal fluid (CSF) to blood for subsequent excretion in urin...
08-07-04摘要:【摘要】 The epithelial Na + channel (ENaC) is regulated by the ubiquitin-protein ligase Nedd4-2 via interaction with ENaC PY-motifs。 These PY-motifs are mutated/deleted in Liddle‘s syndrome...
08-07-04摘要:【摘要】 Cisplatin treatment induces extensive death of the proximal tubules in mice。 We also demonstrated that treatment of immortalized mouse proximal tubule cells (TKPTS) with 25 µ。M...
08-07-04摘要:【摘要】 We tested whether luminal perfusion and pressurization induce an endothelial cytoplasmic Ca 2+ ([Ca 2+ ] CYT ) response in descending vasa recta (DVR)。 4,5-diaminofluoroscein ...
08-07-04摘要:【摘要】 Peroxisome proliferator-activated receptor- (PPAR- ) are ligand-activated transcription factors that regulate cell growth, inflammation, lipid metabolism, and insulin sensitivity。 PP...
08-07-04摘要:【摘要】 In previous studies examining the role of glucocorticoids and thyroid hormone on the maturation of the Na + /H + antiporter (NHE3), we found attenuation in the maturational increase i...
08-07-04摘要:Recently, we found that the expression of VEGF is markedly induced following interactions between CD40 ligand (CD40L) and CD40。 Here, endothelial cells (EC) or Jurkat T cell lines were transiently...
08-07-04摘要:【摘要】 Aquaporin-4 (AQP4) water channels exist as heterotetramers of M1 and M23 splice variants and appear to be present in orthogonal arrays of intramembraneous particles (OAPs) visualized ...
08-07-04摘要:【摘要】 Apoptosis has been implicated in ischemic renal injury。 Thus one strategy of renal protection is to antagonize apoptosis。 However, apoptosis inhibitory approaches remain to be fully...
08-07-04摘要:【摘要】 The tight junction has been characterized as a domain of focal fusions of the exoplasmic leaflets of the lipid bilayers from adjacent epithelial cells。 No known tight junction protei...
08-07-04摘要:SMAD proteins and the JNK1 cascade are essential components of TGF- signaling machinery, and recent data suggest cooperative interaction between JNK1 and SMAD proteins in TGF- -mediated gene expres...
08-07-04摘要:【摘要】 Proximal tubular receptor-mediated endocytosis (RME) of filtered proteins prevents proteinuria。 Pharmacological and genetic studies in cultured opossum kidney cells have shown that t...
08-07-04摘要:【摘要】 VIT32, a vasopressin-induced transcript, inhibits Na + transport when coexpressed with the epithelial sodium channel in Xenopus laevis oocytes ( EMBO J 21: 5109-5117, 2002)。 To under...
08-07-04摘要:【摘要】 The proximal tubule contains an autonomous renin-angiotensin system that regulates transport independently of circulating angiotensin II。 Androgens are known to increase expression o...
08-07-04摘要:【摘要】 The organic cation (OC) transporters OCT1 and OCT2 are suspected of mediating substrate entry from the blood into proximal tubule cells as the first step in renal secretion of OCs。 W...
08-07-04摘要:【摘要】 Urethral closure mechanisms during passive increments in intravesicular pressure (P ves ) were investigated using microtip transducer catheters in urethane-anesthetized female rats。 ...
08-07-04摘要:【摘要】 PGE 2 is a potent stimulator of renin release。 So far, the contribution of each of the four PGE 2 receptor subtypes (EP 1 -EP 4 ) in the regulation of renin release has not been char...
08-07-04摘要:【摘要】 This study investigates the effect of water deprivation on the expression of atrial natiruretic peptide (ANP) 1-28 binding sites in rat kidney。 Water deprivation increased the B max ...
08-07-04摘要:【摘要】 We investigated the effects of nitric oxide (NO) on activity of the inwardly rectifying K + channel in cultured human proximal tubule cells, using the cell-attached mode of the patch-...
08-07-04摘要:【摘要】 NaCl reabsorption in the medullary thick ascending limb of Henle (MTALH) contributes to NaCl balance and is also responsible for the creation of medullary interstitial hypertonicity。...
08-07-04摘要:【摘要】 Although several heavy metal toxins are delivered to the kidney on the carrier protein metallothionein (MT), uncertainty as to how MT enters proximal tubular cells limits treatment st...
08-07-04摘要:We hypothesized a high concentration of glucose could suppress glomerular endothelial nitric oxide synthase (eNOS) by a protein kinase C (PKC) mechanism, as has been found in other tissues。M L -ar...
08-07-04摘要:【摘要】 Attachment of newly formed crystals to renal tubular epithelial cells appears to be a critical step in the development of kidney stones。 The present study was undertaken to identify ...
08-07-04摘要:【摘要】 We showed that renal proximal tubular cells (RPTC) can proliferate and migrate following plating and oxidant or mechanical injury in the absence of exogenous growth factors。 We exami...
08-07-04摘要:【摘要】 Polypeptides present in the glomerular filtrate are almost completely reabsorbed in the first segment of the proximal tubule by receptor-mediated endocytosis。 We have compared the ur...
08-07-04摘要:【摘要】 Identifying genes underlying common forms of kidney disease in humans has proven difficult, expensive, and time consuming。 Quantitative trait loci (QTL) for several complex traits ar...
08-07-04