摘要：【摘要】 The epithelial sodium channel is found in apical membranes of a variety of native epithelial tissues, where it regulates sodium and fluid balance。 In vivo, a number of hormones and o...

摘要：【摘要】 We investigated the involvement of intracellular and extracellular Ca 2+ in the stimulation of Na + transport during hyposmotic treatment of A6 renal epithelia。 A sudden osmotic decr...

摘要：【摘要】 We used a mathematical model of the urine concentrating mechanism of rat inner medulla (IM) to investigate the implications of experimental studies in which immunohistochemical method...

摘要：【摘要】 Vasopressin (AVP) stimulates collecting duct water reabsorption through cAMP-mediated membrane targeting and increased expression of the aquaporin-2 (AQP2) water channel。 The present...

摘要：The antidiuretic hormone AVP plays an important role in renal water excretion by regulating the membrane insertion and abundance of the water channel aquaporin-2 (AQP2)。 this effect is primarily m...

摘要：【摘要】 The present study used a stationary microperfusion technique to investigate in vivo the effect of P2Y 1 receptor activation on bicarbonate reabsorption in the rat proximal tubule。 Pr...

摘要：【摘要】 Hypertension is a common complication of autosomal dominant polycystic kidney disease (ADPKD), often present before the onset of renal failure。 A role for the renin-angiotensin syste...

摘要：【摘要】 Functional reconstruction of inner medullary thin limbs of Henle and collecting ducts (CDs) has enabled us to characterize distinctive three-dimensional vertical and lateral relations...

摘要：They have also been shown to inhibit apoptosis in certain neurodegenerative disorders。 Because ischemic renal injury is characterized by both apoptosis and inflammation, we investigated the therap...

摘要：【摘要】 We investigated the hypothesis that thromboxane A 2 (TxA 2 )-prostaglandin H 2 receptors (TP-Rs) mediate the hemodynamic responses and increase in reactive oxygen species (ROS) to ANG...

摘要：【摘要】 Genetic studies indicated that mutations of the chloride channel CLC-5 in the kidney are responsible for a group of clinical disorders, collectively called Dent‘s disease。 In the ki...

摘要：【摘要】 In the present study, we have investigated whether the hypothalamic paraventricular nucleus (PVN) contributed to the reflex reduction in renal sympathetic nerve activity (RSNA) normal...

摘要：【摘要】 Dysregulation of kidney nitric oxide synthase (NOS) I may alter renal hemodynamics in diabetes。 3 ) The ability of NOS I blockade to increase the homeostatic efficiency of TGF in dia...

摘要：【摘要】 We examined the effects of intracellular Cl - concentration ([Cl - ] i ) on the epithelial Na channel (ENaC) in a line of Madin-Darby canine kidney (MDCK) cells (FL-MDCK) with a high ...

摘要：【摘要】 We present evidence that Na-K-ATPase in the rat proximal tubule is directly activated by ANG II much faster than previously observed。1 and 1 nM ANG II slowed the rate of intracellula...

摘要：【摘要】 ANG II has potent effects on ammonia production and secretion rates by the proximal tubule and is found in substantial concentrations in the lumen of the proximal tubule in vivo。 Bec...

摘要：【摘要】 Chronic acidosis is a stimulus for proteolysis in muscle in vivo, but the mechanism of this response is unknown。 We tested the hypothesis that acidosis or TNF-, a cytokine whose prod...

摘要：【摘要】 The effect of diabetes mellitus on the regulation of urinary bladder smooth muscle contraction was studied。 The bladder was harvested and strips of wall devoid of both mucosa and ser...

摘要：【摘要】 Partial bladder outlet obstruction (PBOO) alters the function of the whole bladder and produces specific alterations in the contractility of the bladder smooth muscle cell。 The goal ...

摘要：【摘要】 Mesangial cells (MG) are an important source of renal PGE 2 and PGI 2。 PGI 2 analog) on MG function and the expression of IP receptors in streptozotocin (STZ)-diabetic rats and gluco...

摘要：【摘要】 Amadori-modified glycated albumin stimulates extracellular matrix and transforming growth factor- (TGF- ) expression in cultured mesangial cells。 Smad proteins transduce the TGF- -me...

摘要：【摘要】 VEGF expression by proximal tubular epithelial cells may play a critical role in maintaining peritubular capillary endothelium in renal disease。 Two major processes involved in renal...

摘要：【摘要】 The hereditary von Hippel-Lindau (VHL) syndrome predisposes sufferers to highly vascularized tumors such as renal clear cell carcinoma (RCC) and central nervous system hemangioblastom...

摘要：【摘要】 Transepithelial salt and fluid secretion mediated by cAMP in initial inner medullary collecting ducts (IMCD i ) may be important for making final adjustments to urine composition。 We...

摘要：【摘要】 The renal collecting duct is the primary site for the ammonia secretion necessary for acid-base homeostasis。 Recent studies have identified the presence of putative ammonia transport...

摘要：【摘要】 We previously demonstrated that endothelial cells are severely damaged during renal ischemia-reperfusion and that transplantation of adult human endothelial cells into athymic nude ra...

摘要：【摘要】 It is well known that tissue factor starts the extrinsic coagulation pathway, which activates factor X to Xa, and factor V is a membrane-bound potent cofactor for the terminating stag...

摘要：【摘要】 Inner medullary collecting ducts (IMCD) are terminally differentiated structures derived from the ureteric bud (UB)。 UB development is mediated by changes in the temporal and spatial...

摘要：【摘要】 Sodium reabsorption and potassium secretion in the distal convoluted tubule and in the connecting tubule can maintain the homeostasis of the body, especially when dietary sodium intak...