摘要：【摘要】 We compared the characteristics of several cloned rabbit organic electrolyte (OE) transporters expressed in cultured cells with their behavior in intact rabbit renal proximal tubules ...

摘要：Recently, we demonstrated that cisplatin-induced inhibition of substrate oxidation can be reversed by the administration of peroxisome proliferator-activated receptor- (PPAR- ) ligands, resulting i...

摘要：【摘要】 Carbon monoxide (CO), a product of heme metabolism by heme oxygenases, is known to impart protection against oxidative stress。 We hypothesized that CO would protect ischemia-reperfus...

摘要：【摘要】 Because 1 -integrin is involved in sensing of fluid flow rate in endothelial cells, a function that in Madin-Darby canine kidney (MDCK) cells is confined to the primary cilium, we hyp...

摘要：【摘要】 Vimentin, an intermediate filament protein mainly expressed in mesenchyma-derived cells, is reexpressed in renal tubular epithelial cells under many pathological conditions, character...

摘要：【摘要】 We used the patch-clamp technique to study the effect of adenosine on the apical 70-pS K channel in the thick ascending limb (TAL) of the rat kidney。M cyclohexyladenosine (CHA), an a...

摘要：【摘要】 Mesangial cell (MC) mitogenesis is regulated through negative cross talk between cAMP-PKA and ERK signaling。 Although it is widely accepted that cAMP inhibits mitogenesis through PKA...

摘要：In the present study, we found that hypotonicity stimulated Na + reabsorption through increases in mRNA expression of the -subunit of the epithelial Na + channel ( -ENaC)。 Hypotonicity decreases c...

摘要：【摘要】 Activation of dopamine D 1A receptors in renal proximal tubules causes inhibition of sodium transporters (Na-K-ATPase and Na/H exchanger), leading to a decrease in sodium reabsorption...

摘要：【摘要】 Heme oxygenase (HO)-derived carbon monoxide (CO) attenuates vascular reactivity to constrictor stimuli。 ANG II produces vasoconstriction and induces HO-1 isoform expression。 However...

摘要：【摘要】 Oxidant stress is an important contributor to renal dysfunction and hypertension。 We have previously demonstrated that regulation of renal oxygen consumption by nitric oxide (NO) is ...

摘要：【摘要】 We previously reported that Na + /H + exchanger type 3 (NHE3) and NaPi2 are acutely retracted from the proximal tubule (PT) microvilli (MV) during acute hypertension [high blood press...

摘要：Liver X receptor- (LXR ) is an intracellular sterol sensor that regulates expression of genes controlling cholesterol absorption, excretion, catabolism, and cellular efflux。 The present study was ...

摘要：【摘要】 Tonicity-responsive enhancer binding protein (TonEBP) is a transcriptional activator of the Rel family。 In the renal medulla, TonEBP stimulates genes encoding proteins involved in ce...

摘要：【摘要】 In adults, the extent of renal reabsorption of P i and consequently the extent of urinary excretion of phosphate are to a large extent determined by the abundance of the Na-P i cotran...

摘要：【摘要】 Purinergic mechanisms appear to be involved in motor as well as sensory functions in the urinary bladder。 ATP released from efferent nerves excites bladder smooth muscle, whereas ATP...

摘要：, vasopressin escape。 Previously, we showed an increase in the whole kidney abundance of aldosterone-sensitive proteins, the - and (70-kDa-band)-subunits of the epithelial Na + channel (ENaC), and...

摘要：【摘要】 This study investigates the effect in rats of acute CdCl 2 (5 µ。M) intoxication on renal function and characterizes the transport of Ca 2+, Cd 2+, and Zn 2+ in the proximal tubu...

摘要：【摘要】 This study evaluated the transduction pathway associated with type 3 Na + /H + exchanger (NHE3) activity-induced inhibition during dopamine D 3 receptor activation in immortalized ren...

摘要：【摘要】 2,3,5-Tris-(glutathion- S -yl)hydroquinone (TGHQ), a reactive metabolite of the nephrotoxicant hydroquinone, induces the ROS-dependent activation of MAPKs, followed by histone H3 phos...

摘要：【摘要】 Acute renal failure (ARF) in septic patients drastically increases the mortality to 50-80%。 Endothelial nitric oxide synthase (eNOS) is one of the major regulators of arterial blood ...

摘要：【摘要】 Chronic renal failure (CRF) is associated with increased risk of arteriosclerotic cardiovascular disease and profound alteration of plasma lipid profile。 Uremic dyslipidemia is marke...

摘要：【摘要】 Apical membrane K channels in the rat connecting tubule (CNT) were studied using the patch-clamp technique。 These correspond closely to the SK-type channels in the cortical collectin...

摘要：【摘要】 We investigated the regulation of organic anion transport driven by the organic anion transporter 3 (OAT3), a multispecific OAT localized at the basolateral membrane of the renal prox...

摘要：【摘要】 Prepubertal onset of diabetes mellitus (DM) in male rats delays diabetic renal hypertrophy and suppresses renal transforming growth factor- (TGF- ) compared with onset in adults。 Bec...