摘要：【摘要】 Progression of renal damage after relief of unilateral ureteral obstruction (UUO) has been demonstrated, especially in neonatal rats。 We evaluated renal function and renal damage aft...

摘要：【摘要】 Induction of cyclooxygenase-2 (COX-2) in the renal pelvic wall increases prostaglandin E 2 (PGE 2 ) leading to stimulation of cAMP production, which results in substance P (SP) releas...

摘要：【摘要】 Cytotoxicity to renal tubular epithelial cells (RTE) is dependent on the relative response of cell survival and cell death signals triggered by the injury。 Forkhead transcription fac...

摘要：【摘要】 Lysophosphatidic acid (LPA), a major member of the bioactive lysophospholipids in serum, possesses diverse physiological activities including cell proliferation。 Recently, three endo...

摘要：【摘要】 In the medullary thick ascending limb (MTAL) of rat kidney, inhibiting basolateral Na + /H + exchange with either amiloride or nerve growth factor (NGF) results secondarily in inhibit...

摘要：【摘要】 The distal convoluted tubule (DCT) is a heterogeneous segment subdivided into early (DCT1) and late (DCT2) parts, depending on the distribution of various transport systems。 We do no...

摘要：In this paper, we have used primary tubular epithelial cell cultures from a tetracycline-inducible- Hif - 1 knockout murine model to further elucidate the role of Hif-1 in the hypoxic-induction of ...

摘要：【摘要】 We tested whether K + channel inhibition accompanies ANG II-induced depolarization of descending vasa recta (DVR) pericytes。 An increase in extracellular K + concentration ([K + ] o ...

摘要：【摘要】 Dietary fructose, NaCl, and/or saturated fat have been correlated with mean arterial pressure (MAP) rises in sensitive strains of rats。 Dysregulation of sodium and/or water reabsorpt...

摘要：【摘要】 In this study, we modeled the production, transport, and consumption of nitric oxide (NO) in the renal medullary microcirculation under basal conditions。 To yield agreement with repo...

摘要：Slc26A4) is a new anion exchanger that is believed to mediate apical Cl - /HCO 3 - exchange in type B and non-A-non-B intercalated cells of the connecting tubule and cortical collecting duct。 Rece...

摘要：This study examined the effect of angiotensin II on the frequency response of the renal vasculature。 Physiological changes in the activity of the endogenous renin-angiotensin system were produced ...

摘要：Recently, two apical calcium channels have been identified, transient receptor potential vanilloid 5 (TRPV5) and TRPV6。 We studied the effects of thiazides on mouse renal calcium handling and rena...

摘要：To gain a better understanding of the role cell-adhesive mechanisms play during renal maturation, we generated proximal tubule and collecting duct cell lines from postnatal day 10 ( P10 ) and P20 b...

摘要：1 was detected in distal convoluted tubules, and weak expression was also detected in thick ascending limb of Henle‘s loop。 Colocalization of Kir5。1 changed the localization of Kir5。 The COOH-t...

摘要：In tubular cells, a primary target for cisplatin is presumably the genomic DNA。 However, the pathway relaying the signals of DNA damage to tubular cell death is unclear。 In response to DNA damage...

摘要：【摘要】 Much evidence points to a relationship among kidney disease, lipoprotein metabolism, and the enzyme lipoprotein lipase (LPL), but there is little information on LPL in the kidney。 Th...

摘要：【摘要】 RET, a tyrosine kinase receptor essential for kidney development, has recently been shown to be important for the formation of the urinary tract。 When RET is overexpressed in the Hox...

摘要：【摘要】 11-Deoxy-16,16-dimethyl PGE 2 (DDM-PGE 2 ) protects renal proximal tubule epithelial cells (LLC-PK 1 ) against the toxicity induced by 2,3,5- tris (glutathion- S -yl)hydroquinone (TGH...

摘要：【摘要】 The adaptation to hypertonicity in mammalian cells is driven by multiple signaling pathways that include p38 kinase, Fyn, the catalytic subunit of PKA, ATM, and JNK2。 In addition to ...

摘要：This can lead to severe water and electrolyte disorders, especially in premature babies。 however, under conditions of water deprivation and after stimulation with DDAVP, it rises to adult levels。...