摘要：Recent studies in Slc26a6 null mice have suggested that this transporter mediates only a portion of proximal tubule Cl - /base exchange, raising the possibility that one or more unidentified apical...

摘要：【摘要】 ANG II, a mediator of renal injury in diabetic renal disease, promotes vascular endothelial growth factor (VEGF) mRNA translation in proximal tubular epithelial (MCT) cells (Feliers D...

摘要：【摘要】 SGLT1 (SLC5A1) mediates a part of glucose and galactose reabsorption in the mammalian proximal tubule (PT), but the detailed localization of the transporter along the tubule is still ...

摘要：【摘要】 The human organic anion transporter, OAT3 ( SLC22A8 ), plays a critical role in renal drug elimination, by mediating the entry of a wide variety of organic anions, including a number ...

摘要：【摘要】 Renal prostanoids are important regulators of normal renal function and maintenance of renal homeostasis。 In diseased kidneys, renal cylooxygenase (COX) expression and prostanoid for...

摘要：【摘要】 The mechanism of solute accumulation in the renal inner medulla remains an unresolved issue。 Experiments were carried out in hamsters to address the possibility that the peristaltic ...

摘要：Using mice with deletion of the A 1 adenosine receptor (A1AR) gene, we tested the prediction that the absence of TGF, previously established to result from A1AR deficiency, is associated with a red...

摘要：【摘要】 Most neutral L -amino acid acids are transported actively across the luminal brush-border membrane of small intestine and kidney proximal tubule epithelial cells by a Na + cotransport...

摘要：【摘要】 Previous studies have shown that L-type Ca 2+ channel (LCC) blockers primarily dilate resting and ANG II-constricted afferent arterioles (AA), but do not influence either resting or A...

摘要：【摘要】 The arachidonate signaling pathways comprise prostanoids formed by cyclooxygenases, EETs, and HETEs formed by cytochrome P -450 (CYP) enzymes and HETEs and leukotrienes generated by l...

摘要：【摘要】 Angiotensin-converting enzyme (ACE) inhibitors such as captopril, which block ANG II formation, are commonly used for treatment of hypertension。 There is substantial evidence that th...

摘要：【摘要】 Experiments were performed to characterize renal hemodynamics in Thy-1 nephritic rats。 A monoclonal antibody against Thy-1 was intravenously injected to induce mesangiolysis in rats,...

摘要：【摘要】 NHERF-1 binds numerous renal protein targets, including the proximal tubule transporters Na + /H + exchanger 3 (NHE3) and Na + -phosphate cotransporter 2a (Npt2a)。 Young NHERF-1 -/- ...

摘要：【摘要】 We previously demonstrated the anti-inflammatory effects and renal tissue protection in response to adenosine A 2A -receptor (A 2A R) activation in acute renal injury。 We sought to e...

摘要：【摘要】 Activity of the epithelial Na + channel (ENaC) is limiting for Na + reabsorption at the distal nephron。 Gain-of-function mutations in ENaC cause Liddle‘s syndrome: a severe form of ...

摘要：Previously, we demonstrated that 5-chloro-2-{(1E)-3-[2-(4-methoxybenzoyl)-4-methyl-1H-pyrrol-1-yl]prop-1-en-1-yl}- N -(methylsulfonyl)benzamide (SMP-534) reduces extracellular matrix (ECM) producti...

摘要：【摘要】 We used Western blotting to examine the expression of phosphatidylinositol 3-kinase (PI3K) in the renal cortex and outer medulla and employed the patch-clamp technique to study the ef...

摘要：【摘要】 Our study aimed to characterize the influence of changes in extracellular osmolarity on renin secretion from the whole kidney。 For this purpose, the osmolarity of the perfusion mediu...

摘要：Here, we examined the effect of a novel water-soluble carbon monoxide-releasing molecule (CORM-3) on CP-mediated cytotoxicity in renal epithelial cells and explored the potential therapeutic benefi...

摘要：【摘要】 Reactive oxygen and nitrogen species play a key role in the pathophysiology of renal ischemia-reperfusion (I/R) injury。 Recent studies have shown that nitrite (NO 2 - ) serves as an ...