摘要：【摘要】 Ouabain, a cardiotonic steroid and a specific inhibitor of the Na + -K + -ATPase, has been shown to significantly inhibit transcellular Na + transport without altering the intracellul...

摘要：【摘要】 Aquaporin-2 (AQP2), when expressed in fully differentiated 3T3-L1 adipocytes, displays cAMP-dependent plasma membrane translocation in a manner similar to its behavior in renal epithe...

摘要：【摘要】 This review considers many new basic and clinical aspects of parathyroid hormone (PTH)。 We focus especially on the identification of PTH fragments and how they may relate to renal fa...

摘要：【摘要】 Magnetic resonance imaging (MRI) provides exquisite anatomic detail of various organs and is capable of providing additional functional information。 This combination allows for compr...

摘要：【摘要】 The epithelial Na + channel (ENaC) is an end-effector of diverse cellular signaling cascades, including those with phosphatidylinositide second messengers。 Recent evidence also sugge...

摘要：【摘要】 Megalin is a multiligand receptor heavily involved in protein endocytosis。 We recently demonstrated that megalin binds and mediates internalization of ANG II。 Although there is a st...

摘要：【摘要】 Pharmacological interruption of the angiotensin II (ANG II) type 1 receptor signaling during nephrogenesis in rats perturbs renal tubular development。 This study aimed to further inv...

摘要：【摘要】 In the kidney, the epithelial Ca 2+ channel TRPV5 constitutes the apical entry pathway in the process of active Ca 2+ reabsorption。 The regulation of Ca 2+ influx through TRPV5 is of...

摘要：【摘要】 It is well established that transient receptor potential (TRP) channels are activated following stimulation of G protein-coupled membrane receptors linked to PLC, but their differenti...

摘要：Incubation of human proximal tubular epithelial (HKC) cells with IFN- inhibited TGF- 1 -mediated -smooth muscle actin ( -SMA) expression。 IFN- also abolished TGF- 1 -induced fibronectin and plasmi...

摘要：【摘要】 Lithium-induced nephrogenic diabetes insipidus (Li-NDI) is associated with increased urinary sodium excretion and decreased responsiveness to aldosterone and vasopressin。 Dysregulati...

摘要：【摘要】 The present study evaluated whether the impairment in autoregulation of renal blood flow (RBF) in the fawn-hooded Hypertensive (FHH) rat colocalizes with the Rf-1 region on chromosome...

摘要：【摘要】 Apoptosis and epithelial-mesenchymal transdifferentiation (EMT) occur in stressed tubular epithelial cells and contribute to renal fibrosis。 Direct (caspase inhibition) and indirect ...

摘要：【摘要】 SLC26A7 is a newly identified basolateral Cl - /HCO 3 - exchanger specific to -intercalated cells of the outer medullary collecting duct (OMCD)。 The purpose of the present experiment...

摘要：【摘要】 Renal ischemia-reperfusion injury (IRI) is the leading cause of acute kidney injury [AKI。 acute renal failure (ARF)] in native kidneys and delayed graft function in deceased donor ki...

摘要：【摘要】 Angiotensin (ANG) type 1A (AT 1A ) receptor-null (AT 1A -/- ) mice exhibit reduced afferent arteriolar (AA) constrictor responses to ANG II compared with wild-type (WT) mice, whereas ...

摘要：【摘要】 Hypertonicity activates the transcription factor tonicity-responsive enhancer/osmotic response element binding protein (TonEBP/OREBP), resulting in increased expression of genes invol...

摘要：【摘要】 We used the patch-clamp technique to examine the effect of adenosine on epithelial sodium channel (ENaC) activity in rat cortical collecting duct (CCD)。 Application of adenosine inhi...

摘要：【摘要】 Maternal renal disease is associated with high maternal and fetal morbidity。 To establish an animal model to study renal dysfunction in pregnancy and its potential role in programmin...

摘要：【摘要】 The distribution and function of P2X and P2Y receptor subtypes were investigated on intact or cultured intramural ganglia of the cat urinary bladder by immunocytochemistry and calcium...

摘要：【摘要】 Urinary diluting ability and protein abundance of renal aquaporins (AQPs) and ion transporters in glucocorticoid-deficient (GD) rats were examined at baseline and in response to oral ...

摘要：【摘要】 Rigorous study of the associations between urethral structural anatomy and biomechanical function is necessary to advance the understanding of the development, progression, and treatm...

摘要：【摘要】 OCT2, an organic cation transporter critical for removal of many drugs and toxins from the body, contains consensus sites for N -glycosylation at amino acid position 71, 96, and 112。...

摘要：【摘要】 Because nuclear factor of activated T cells (NFAT) has been implicated in TNF production as well as osmoregulation and salt and water homeostasis, we addressed whether calcium-sensing...

摘要：【摘要】 We identified a consensus N-linked glycosylation motif within the pore-forming loop between the fifth and sixth transmembrane segments of the osmoresponsive transient receptor potenti...

摘要：【摘要】 The renal-specific Na + -K + -2Cl - cotransporter NKCC2 belongs to the SLC12 gene family。 Because the NKCC2 sequence contains two putative N -linked glycosylation sites, one of which...

摘要：In this study, we investigated long-term effects of PDGF-BB on Cx43 expression in mesangial cells (MCs)。 Exposure of MCs to PDGF-BB affected neither the Cx43 protein level nor GJIC。 However, in t...

摘要：【摘要】 Cadmium is a potent nephrotoxin that has been shown to induce apoptosis in some cells but also to prevent it under certain circumstances。 In several clinical situations and experimen...

摘要：【摘要】 Liver X receptors (LXRs), including LXR and LXR, are intracellular sterol sensors that regulate expression of genes controlling fatty acid and cholesterol absorption, excretion, catab...

摘要：【摘要】 Hyperinsulinemia is associated with hypertension。 Dysregulation of renal distal tubule sodium reabsorption may play a role。 We evaluated the regulation of the epithelial sodium chan...

摘要：【摘要】 The susceptibility or resistance of tubular epithelial cells (TEC) to apoptosis is pivotal to the long-term maintenance of kidney function following episodes of inflammation, such as ...

摘要：【摘要】 Toll-like receptors (TLRs) are now recognized as the major receptors for microbial pathogens on cells of the innate immune system。 Recently, TLRs were also identified in many organs ...

摘要：【摘要】 Angiotensin IV (ANG IV), an active ANG II fragment, has been shown to induce systemic and renal cortical effects by binding to ANG IV (AT 4 ) receptors and activating unique signaling...

摘要：【摘要】 Adenosine acting through A 1 adenosine receptors (A1AR) has been shown previously to be required for the vasoconstriction elicited by high luminal NaCl concentrations at the macula de...

摘要：To examine whether Q O 2 /T Na depends on the mechanism of sodium reabsorption, we first evaluated the effects on Q O 2 and Q O 2 /T Na of benzolamide (BNZ), a proximal diuretic that works by inhib...