摘要：【摘要】 Although ATP has been shown to act as a modulator in various kidney functions, its effect on renal proximal tubule cell (PTC) proliferation has not been elucidated。 This study invest...

摘要：【摘要】 The differentiation of cultured stratified epithelial cells can deviate significantly from that of normal epithelium, leading to suggestions that cultured cells undergo abnormal diffe...

摘要：We used a mathematical model of tubuloglomerular feedback (TGF) to investigate potential sources of the irregular oscillations and the corresponding complex power spectra in SHR。 Four potential so...

摘要：In this study, we demonstrate the anti-inflammatory and antinecrotic effects of sevoflurane in cultured kidney proximal tubule cells and probed the mechanisms of sevoflurane-induced renal cellular ...

摘要：【摘要】 Dopamine via activation of renal D 1 -like receptors inhibits the activities of Na-K-ATPase and Na/H exchanger and subsequently increases sodium excretion。 We have earlier reported D...

摘要：【摘要】 Previously, we demonstrated that rats undergoing vasopressin escape had increased mean arterial blood pressure (MAP), plasma and urine aldosterone, and increased renal protein abundan...

摘要：【摘要】 Lithium (Li) treatment for 4 wk has previously been shown to increase the fraction of intercalated cells in parallel with a decrease in the fraction of principal cells in the kidney c...

摘要：【摘要】 Vasopressin increases urine concentration by stimulating plasma membrane accumulation of aquaporin-2 (AQP2) in collecting duct principal cells, allowing bulk water flow across the col...

摘要：【摘要】 The structural and functional heterogeneity of the collecting duct present a tremendous experimental challenge requiring manual microdissection, which is time-consuming, labor intensi...

摘要：【摘要】 The purpose of this study was to evaluate whether upregulated p21, a cell cycle-inhibitory protein, contributes to cisplatin (CDDP)-induced acute renal failure (ARF) and to acquired r...

摘要：【摘要】 Over the past 10 years, animal studies have uncovered the molecular mechanisms for the renal tubular recovery of filtered vitamin and vitamin carrier proteins。 Relatively few endocyt...

摘要：【摘要】 To identify novel gene targets of vasopressin regulation in the renal medulla, we performed a cDNA microarray study on the inner medullary tissue of mice following a 48-h water restri...

摘要：Puromycin aminonucleoside (PAN)-induced NS is associated with high aldosterone levels and increased ENaC expression and apical targeting。 However, the mechanisms associated with increased apical t...

摘要：【摘要】 Vascular endothelial growth factor (VEGF)-A is an autocrine survival factor for podocytes, which express two VEGF receptors, VEGF-R1 and VEGF-R3。 As VEGF-A is not a known ligand for ...

摘要：【摘要】 To investigate the underlying causes for aldose reductase deficiency-induced diabetes insipidus, we carried out studies with three genotypic groups of mice。 These included wild-type ...

摘要：【摘要】 Endothelial progenitor cells (EPCs) have been shown to participate in tissue repair under diverse physiological and pathological conditions。 It is unknown whether EPCs are mobilized ...

摘要：【摘要】 Although chronic exposure of renal cells to high glucose has been shown to cause cell injury, the effect of acute exposure has not been elucidated。 In this study, we demonstrate that...

摘要：【摘要】 Dilation of rat preglomerular microvessels (PGMV) by activation of adenosine A 2A receptors (A 2A R) is coupled to epoxyeicosatrienoic acid (EET) release。 Male Sprague-Dawley rats we...

摘要：【摘要】 The Gamble phenomenon (initially described over 70 years ago as an economy of water in renal function referable to urea) suggested that urea plays a special role in the urinary concen...

摘要：【摘要】 The aim of this study was to investigate ANG II-induced Ca 2+ signaling in freshly isolated afferent arterioles (AA) from two-kidney, one-clip hypertensive (2K1C) rats, which have an ...

摘要：【摘要】 We studied the proton secretion mechanisms involved with pH i regulation in immortalized rat proximal tubule cells (IRPTC), a SV40-immortalized cell line derived from rat proximal tub...

摘要：Monolayers of MDCK-mUT-A2 cells had a basal phloretin-inhibitable urea permeability of 8。 Treatment of MDCK-mUT-A2 monolayers with AVP led to a rapid dose-dependent increase in trans -monolayer ph...

摘要：【摘要】 In the current study, we investigated the effect of simvastatin on the ability of high glucose (HG) and ANG II to activate the JAK2-STAT signaling cascade and induce glomerular mesang...

摘要：【摘要】 The present studies were designed to determine whether mice heterozygous for deletion of -ENaC exhibited defects in Na + /K + transport and blood pressure regulation。 In response to ...

摘要：【摘要】 Many of the signaling pathways that regulate tissue specification and coordinate cellular differentiation during embryogenesis have been identified over the last decade。 Such develop...