摘要：【摘要】 The distal convoluted tubule (DCT) apical Na + -Cl - cotransporter (NCC) is responsible for the reabsorption of 5-10% of filtered NaCl and is the target for thiazide diuretics。 NCC a...

摘要：More importantly, dynamic processes and multiple functions of an intact organ can be visualized in real time using noninvasive methods, and quantified。 These studies aimed to extend existing metho...

摘要：Fibroblast growth factor 10 (FGF-10) is a mitogen which is particularly promising as a protein therapy for urothelial injury。 The spatial synthesis, transport, targeting, and mechanistic pathway o...

摘要：【摘要】 ATP release from macula densa (MD) cells into the interstitium of the juxtaglomerular (JG) apparatus (JGA) is an integral component of the tubuloglomerular feedback (TGF) mechanism th...

摘要：【摘要】 Transgenic mouse models of defective urinary concentrating ability produced by deletion of various membrane transport or receptor proteins, including aquaporin-2 (AQP2), are associate...

摘要：【摘要】 Kim-1, a recently discovered membrane protein, is undetectable in normal kidneys but markedly induced in proximal tubules after ischemic and toxic injury。 The function of Kim-1 is un...

摘要：【摘要】 Previous studies have shown that renal injury initiated by a lethal dose of S -1,2-dichlorovinyl- L -cysteine (DCVC) progresses due to inhibition of cell division and hence renal repa...

摘要：【摘要】 Aquaporin-1 (AQP1) and aquaporin-3 (AQP3) water channels expressed in the kidney play a critical role in the urine concentrating mechanism。 Mice with AQP1 or AQP3 deletion have a uri...

摘要：【摘要】 Vascular endothelial growth factor (VEGF-A) signaling is required for endothelial cell differentiation, vasculogenesis, angiogenesis, and vascular patterning。 During kidney morphogen...

摘要：【摘要】 We tested the hypothesis that cytosolic and membrane-associated carbonic anhydrase (CA IV) are involved in renal urinary acidification and bicarbonate reabsorption in rainbow trout。 ...

摘要：Polycystin- L is found mostly in the endoplasmic reticulum in subconfluent cell cultures, while in confluent cells it is redistributed to sites of cell-cell contact and to the primary cilium as is ...

摘要：【摘要】 The present study investigated the role of IL-10 produced by the mesangial cells in postnephrectomy compensatory renal growth and the effect of the immunomodulator AS101 on this proce...

摘要：【摘要】 Long-term angiotensin II (ANG II) administration is associated with increased ANG II accumulation in the kidney, but intrarenal compartment(s) involved in this response remains to be ...

摘要：【摘要】 Renal cortical cyclooxygenase-2 (COX-2) is restricted to the macula densa and adjacent cortical thick ascending limbs (MD/cTALH)。 Renal cortical COX-2 increases in response to diabet...

摘要：【摘要】 A previous study demonstrated that proximal tubule cells regulate HCO 3 - reabsorption by sensing acute changes in basolateral CO 2 concentration, suggesting that there is some sort o...

摘要：【摘要】 Hypertension is associated with increased levels of oxidative stress and medullary renal injury。 Previous studies have shown that elevations in renal perfusion pressure increase Na +...

摘要：【摘要】 The response of renal inner medullary (IM) collecting duct cells (mIMCD3) to high NaCl involves increased expression of Gadd45 and p53, both of which have important effects on growth ...

摘要：【摘要】 Recent reports have proposed that the urothelium can sense mechanical stretch and communicate this information to sensory afferent neurons by the release of ATP into the vicinity of P...

摘要：【摘要】 Chronic metabolic acidosis (CMA) is associated with decreased NaCl reabsorption in the proximal tubule (PT)。 Metabolic acidosis developed within 24 h in NH 4 Cl-, but not in KCl-load...

摘要：【摘要】 Recently, a novel Slc22 gene family member expressed in murine olfactory mucosa was identified and based on sequence homology proposed to be an organic anion transporter [Oat6 ( Slc22...

摘要：【摘要】 Chronic upregulation of the renal betaine/GABA transporter (BGT1) by hypertonic stress has been well documented, but it is not known whether BGT1 can be regulated acutely after insert...

摘要：【摘要】 To examine the mechanisms whereby amino acids modulate nitric oxide (NO) production and blood flow in the renal vasculature, chemiluminescence techniques were used to quantify NO in t...

摘要：【摘要】 Basic fibroblast growth factor (bFGF) is a heparin-binding growth factor that is accumulated in human dysplastic and cystic renal diseases。 Previous studies have shown that bFGF can ...

摘要：To test the role of extracellular formation of adenosine by ecto-5‘-nucleotidase (cd73) in TGF, in regulation of GFR, and in tubular reabsorption, renal clearance and micropunture experiments were...

摘要：【摘要】 Tissue hypoxia not only occurs under pathological conditions but is also an important microenvironmental factor that is critical for normal embryonic development。 Hypoxia-inducible f...

摘要：【摘要】 In the renal collecting duct, water reabsorption is regulated by the antidiuretic hormone vasopressin (AVP)。 Binding of this hormone to the vasopressin V2 receptor (V2R) leads to ins...