摘要：【摘要】 Our hypothesis is that impairment of peroxisome proliferator-activated receptor- (PPAR ) initiates renal dysfunction by increasing renal glomerular matrix metalloproteinase-2 (MMP-2) ...

摘要：【摘要】 Antibodies directed against subunits of the epithelial Na channel (ENaC) were used together with electrophysiological measurements in the cortical collecting duct to investigate the p...

摘要：【摘要】 In response to gestational high salt intake, BdkrB2 -/- embryos acquire an aberrant renal phenotype mimicking renal dysplasia in humans。 Genetic analysis identified p53 as a mediator...

摘要：【摘要】 Vectorial Na + absorption across the aldosterone-sensitive distal nephron plays a key role in the regulation of extracellular fluid volume and blood pressure。 Within this nephron seg...

摘要：Here, we show the existence of mRNA for BMP-2 and for the BMP receptors BMPR1A, BMPR1B, BMPRII, ACVR1A, ACVR2, and ACVR2B in differentiated mouse podocytes and the protein expression of BMPR1A in h...

摘要：【摘要】 Previous studies of intrarenal perfusion and tissue oxygenation have produced a wide range of results and have not matched tissue oxygen tension (tP O 2 ) with concurrent changes in f...

摘要：【摘要】 Renal prostaglandins modulate the activity of a number of the transport systems in the kidney, including the Na-K-ATPase。 Not only do prostaglandins have acute affects on renal Na-K-...

摘要：【摘要】 We examined the magnitude of adaptive hyperfiltration in the 57 yr) and 16 youthful (55 yr) individuals who had undergone a contralateral nephrectomy。 Healthy volunteers who were you...

摘要：【摘要】 Endothelial dysfunction in ischemic acute renal failure (IARF) has been attributed to both direct endothelial injury and to altered endothelial nitric oxide synthase (eNOS) activity, ...

摘要：【摘要】 The present study was performed to determine the effects of cyclooxygenase (COX)-1 and COX-2 inhibition on blood pressure and renal hemodynamics in transgenic rats with inducible mali...

摘要：【摘要】 Renal ischemia-reperfusion (I/R) results in vascular dysfunction characterized by a reduced endothelium-dependent vasodilatation and subsequently impaired blood flow。 In this study, ...

摘要：【摘要】 Insulin-resistant, obese Zucker rats have blunted pressure natriuresis and are mildly hypertensive。 Male lean (L) and obese (O) Zucker rats were infused with aldosterone (2。02% NaCl...

摘要：【摘要】 Sodium bicarbonate cotransporter 1 (NBC1) mediates 80% of bicarbonate reabsorption by the kidney, but the molecular determinants for activity, targeting, and cell membrane stability a...

摘要：【摘要】 The role of caspases and calpain in cisplatin-induced endothelial cell death is unknown。 Thus we investigated whether caspases and calpain are mediators of cisplatin-induced apoptosi...

摘要：【摘要】 Prostasin is a glycosylphosphatidylinositol-anchored serine protease, with epithelial sodium channel activation and tumor invasion suppression activities。 In mice injected intraperit...

摘要：【摘要】 In macrophages and osteoclast precursors, the cytokines TNF and RANK-L induce similar downstream pathways and share some of the same adaptor molecules。 In this report, we investigate...

摘要：【摘要】 Acute renal failure (ARF) markedly sensitizes mice to endotoxin (LPS), as evidenced by exaggerated renal cytokine/chemokine production。 This study sought to further characterize this...

摘要：【摘要】 We have previously shown that systemic treatment with the somatostatin analog octreotide has marked beneficial effects on renal function in rats with liver cirrhosis induced by common...

摘要：【摘要】 We have investigated urine protein inhibitors of calcium oxalate crystallization to determine whether variations in these proteins are associated with kidney stone disease and whether...

摘要：【摘要】 Although it is generally accepted that ROMK is the K + secretory channel in the mammalian distal nephron, recent in vitro and in vivo studies have provided evidence that large-conduct...

摘要：【摘要】 Nucleic acids provide more than the genetic code that determines the morphological and functional phenotype of microbes and eukaryotes。 In fact, nucleic acids have immunomodulatory f...