摘要:We investigated whether NF- B inhibition limits progressive renal injury in the 5/6 renal ablation model (Nx)。 Thirty days after renal ablation, Nx rats exhibited systemic and glomerular hypertens...
08-07-04摘要:【摘要】 Despite the evidence that angiotensin-converting enzyme (ACE)2 is a component of the renin-angiotensin system (RAS), the influence of ACE2 on angiotensin metabolism within the kidney ...
08-07-04摘要:【摘要】 In view of its proven antiproliferative effects, rapamycin offers potential in the treatment of mesangioproliferative disease。 Previous data have shown an effect of rapamycin on mesa...
08-07-04摘要:Therefore, the effects of glibenclamide (Glib) on net collagen I, collagen IV, and fibronectin medium net secretion and cell layer collagen I deposition were investigated in mesangial cells continu...
08-07-04摘要:【摘要】 Idiopathic hypercalciuria (IH) is common among calcium stone formers (IHSF)。 The increased urinary calcium arises from increased intestinal absorption of calcium, but it is unclear w...
08-07-04摘要:The following equation is fitted to this data to derive parameters, such as the mass transfer area coefficient (MTAC), to characterize the rate of solute transfer across the peritoneumwhere V pc is...
08-07-04摘要:【摘要】 Here we describe the generation and characterization of a mouse strain that expresses an improved Cre (iCre) recombinase ( 48 ) under the control of the endogenous 11 -hydroxysteroid ...
08-07-04摘要:Ischemic preconditioning (IP) represents a powerful strategy for kidney protection, and recent advances in transgenic mice may help elucidate its molecular mechanisms。 Thus we developed a novel mo...
08-07-04摘要:【摘要】 Low biocompatibility of peritoneal dialysis fluid (PDF) injures mesothelial cells and activates their stress response。 In this study, we investigated the role of heat shock proteins ...
08-07-04摘要:【摘要】 Although the mammalian urinary tract is generally held to be solely a transit and storage vehicle for urine made by the kidney, in vivo data suggest reabsorption of urea and other uri...
08-07-04摘要:【摘要】 Glucocorticoids are involved in many aspects of regulation of acid-base homeostasis, including the stimulation of renal ammoniagenesis during chronic metabolic acidosis。 Expression o...
08-07-04摘要:Because KCNQ1 participates in K + secretion within the inner ear and stomach, distribution of KCNQ1 in mouse kidney was studied using Northern and Western analyses, RT-PCR of isolated tubules, and ...
08-07-04摘要:【摘要】 Reactive oxygen species, including hydrogen peroxide (H 2 O 2 ), are generated during ischemia-reperfusion and are critically involved in acute renal failure。 The present studies exa...
08-07-04摘要:【摘要】 Normally, the small amount of albumin which passes through the glomerular capillary wall is almost completely reabsorbed in the proximal tubule, via an endocytic mechanism, but the re...
08-07-04摘要:【摘要】 Fructose intake has been recently linked to the epidemic of metabolic syndrome and, in turn, the metabolic syndrome has been epidemiologically linked with renal progression。 Metaboli...
08-07-04摘要:【摘要】 In the current experiments, we determined the response of plasma renin concentration (PRC) to acute intraperitoneal administration of furosemide (40 mg/kg), hydralazine (2 mg/kg), iso...
08-07-04摘要:【摘要】 Rat descending vasa recta (DVR) express a tetrodotoxin (TTX)-sensitive voltage-operated Na + (Na V ) conductance。 We examined expression of Na V isoforms in DVR and tested for regula...
08-07-04摘要:【摘要】 Hereditary hypophosphatemic rickets with hypercalciuria results from mutations of the renal type IIc Na-P i cotransporter gene, suggesting that the type IIc transporter plays a promin...
08-07-04摘要:【摘要】 Aldosterone induces redistribution of epithelial sodium channel (ENaC) to the apical plasma membrane from intracellular vesicles in renal connecting tubule (CNT) and cortical collecti...
08-07-04摘要:Active secretion in the proximal nephron is at the basis of this excretion, mediated by carrier proteins including multidrug resistance protein 2 (Mrp2)。 In the present study, we studied the effec...
08-07-04摘要:【摘要】 The accumulation of uric acid, an end-product of purine metabolism, is responsible for the many deleterious effects observed in gouty arthritis, including renal injury。 Here, we pres...
08-07-04摘要:【摘要】 The renal reabsorption and/or excretion of various organic anions is mediated by specific organic anion transporters (OATs)。 OAT2 (Slc22a7) has been identified in rat kidney, where i...
08-07-04摘要:【摘要】 Vasopressin and vasopressin antagonists are finding expanded use in mouse models of disease and in clinical medicine。 To provide further insight into the physiological role of V1a an...
08-07-04摘要:【摘要】 Vasopressin and angiotensin II (ANG II) play a major role in renal water and Na + reabsorption。 We previously demonstrated that ANG II AT 1 receptor blockade decreases dDAVP-induced ...
08-07-04摘要:【摘要】 Chronic angiotensin (ANG) II infusions into rats lead to augmented intrarenal levels of ANG II and inflammatory factors, impaired renal function, and progressive hypertension。 Residu...
08-07-04摘要:【摘要】 Transforming growth factor- (TGF- ) is a key mediator in the pathogenesis of renal diseases。 Betaglycan, also known as the type III TGF- receptor, regulates TGF- action by modulating...
08-07-04摘要:【摘要】 Kidney injury molecule-1 (Kim-1) is associated with ischemic and proteinuric tubular injury。 however, whether dysregulation of the renin-angiotensin system (RAS) can also induce Kim-...
08-07-04摘要:【摘要】 Acute renal failure (ARF) induces tubular hyperresponsiveness to TLR4 ligands, culminating in exaggerated renal cytokine/chemokine production。 However, the fate of TLR4 protein durin...
08-07-04摘要:【摘要】 Protein kinase B (Akt) activation is well known for its protective effects against apoptosis。 However, the role of Akt in regulation of necrosis is unknown。 This study was designed ...
08-07-04摘要:【摘要】 Here, we demonstrate that the Ca 2+ /calmodulin-sensitive phosphatase calcineurin is a necessary downstream mediator for osteoclast differentiation。 Using quantitative PCR, we detect...
08-07-04摘要:【摘要】 The homeostatic function of prostaglandin E 2 (PGE 2 ) is dependent on a balance of EP receptor-mediated events。 Although PGE 2 excretion is elevated in diabetes, the expression of s...
08-07-04摘要:【摘要】 By crossing mice with expression of Cre recombinase under control of the endogenous renin promoter (Sequeira Lopez ML, Pentz ES, Nomasa T, Smithies O, Gomez RA。 Dev Cell 6: 719-728, ...
08-07-04摘要:【摘要】 This study was conducted to test the hypothesis that, during renal development, the Na-K-2Cl cotransporter type 2 (NKCC2) activates the tonicity-responsive enhancer binding protein (T...
08-07-04摘要:【摘要】 The mortality rate for septic patients with acute renal failure is extremely high。 Intravital video microscopy was utilized to investigate renal peritubular capillary blood flow in a...
08-07-04摘要:【摘要】 Intracellular retention of a functional vasopressin V2 receptor (V2R) is a major cause of congenital nephrogenic diabetes insipidus (NDI) and rescue of V2R mutants by nonpeptide antag...
08-07-04摘要:【摘要】 Under hypoxia, some cells survive and others are irreversibly injured and die。 The factors that determine cell fate under stress remain largely unknown。 We recently selected death-r...
08-07-04摘要:【摘要】 The function of the NaPiIIa renal sodium-phosphate transporter is regulated through a complex network of interacting proteins。 Several PDZ domain-containing proteins interact with it...
08-07-04摘要:【摘要】 Previously, in our laboratory a 40-kDa zinc transporter protein was purified and functionally reconstituted in proteoliposomes (Kumar R, Prasad R。 Furthermore, we now report the iden...
08-07-04摘要:【摘要】 Hypoxia inducible factor (HIF) prolyl-4-hydroxylase domain-containing proteins (PHDs) promote the degradation of HIF-1。 Because HIF-1 is highly expressed in the renal medulla and HIF...
08-07-04摘要:【摘要】 Myelomeningocele (MMC) is the most common cause of neurogenic bladder dysfunction (NBD)。 The objective of this study was to use this model to assess functional and structural charact...
08-07-04