摘要：【摘要】 The mammalian counterpart of the fish calcium-regulating hormone stanniocalcin-1 (STC1) inhibits monocyte chemotactic protein-1- and stromal-derived factor-1 (SDF-1 )-mediated chemota...

摘要：【摘要】 Exogenous bilirubin (BR) substitutes for the protective effects of heme oxygenase (HO) in several organ systems。 Bilateral renal clamping (30 min) was followed by 6-h reperfusion。 G...

摘要：Real-time PCR analyses showed a dose-dependent induction of MCP-1 and the Th1-type chemokines IP10 and Mig as well as their receptor CXCR3 and the Th1 cytokine IFN-。 In situ hybridization and lase...

摘要：【摘要】 We investigated the role of the prostaglandin E 2 (PGE 2 ) EP 1 receptor in modulating urine concentration as it is expressed along the renal collecting duct where arginine-vasopressi...

摘要：The proximal tubule cell (PTC) is responsible for the reabsorption of 5-8 g of glomerular filtered albumin each day。 This investigation examined the role of ANG II-induced oxidative stress in PTC ...

摘要：Our previous work in rabbit renal proximal tubular cells (RPTC) demonstrated that inhibition of Ca 2+ -independent phospholipase A 2 (iPLA 2 ) potentiates oxidant-induced lipid peroxidation and nec...

摘要：【摘要】 Ste20-like kinase, SLK, a germinal center kinase found in kidney epithelial cells, signals to promote apoptosis。 Expression of SLK mRNA and protein and kinase activity are increased ...

摘要：【摘要】 Proteinuria contributes to chronic kidney disease by stimulating renal tubular epithelial cells to produce cytokines such as monocyte chemoattractant protein-1 (MCP-1)。 The present s...

摘要：cm 2, depending on the degree of sealing of the tight junction (TJ)。 We found that its main TER-increasing component is epidermal growth factor (hEGF), as depletion of this peptide with specific a...

摘要：【摘要】 Induction of streptozotocin (STZ) diabetes in hypertensive rats transgenic for the mouse ren-2 gene (TGR) has been described as a model of progressive diabetic nephropathy。 We invest...

摘要：【摘要】 Acute renal failure often occurs in the clinical setting of multiple renal insults。 Tumor necrosis factor- (TNF- ) has been implicated in the pathogenesis of cisplatin nephrotoxicity...

摘要：【摘要】 Severe sepsis is accompanied by acute renal failure (ARF) with renal tubular dysfunction and glucosuria。 In this study, we aimed to determine the regulation of renal tubular glucose ...

摘要：【摘要】 Large differences in the tolerance of organ systems to conditions of decreased O 2 delivery such as hemodilution exist。 In a rat model of acute normovolemic hemodilution (ANH), we st...

摘要：【摘要】 Glomerular cells in culture respond to albumin containing Amadori glucose adducts (the principal serum glycated protein), with activation of protein kinase C- 1, increased expression ...

摘要：【摘要】 Peptides play important roles in cell regulation and signaling in many tissues and are regulated by peptidases, most of which are highly expressed in the kidney。 Several peptide conv...

摘要：【摘要】 Recent studies have demonstrated that klotho protein plays a role in calcium/phosphate homeostasis。 The goal of the present study was to investigate the regulation of Na-P i cotransp...

摘要：【摘要】 In many clinical settings, the duration of renal ischemia and therefore the outcome of acute renal failure cannot be determined adequately。 So far, the expression and role of CDK inh...

摘要：We discovered that brief administration of a low-molecular-weight synthetic peptide, poly- D -glutamic acid (PDG), induced prompt and robust expansion of EPO-producing PIC in rat kidney, without ev...

摘要：Here, we examined the effects of the ANG II receptor type 1 (AT1R) blockade using candesartan on long-term renal molecular and functional changes in response to partial unilateral ureteral obstruct...

摘要：【摘要】 Growth hormone (GH) has antidiuretic and antinatriuretic effects in rats and humans, but the molecular mechanisms responsible for these effects are unknown。 The aim of this study was...

摘要：【摘要】 We developed a two-dimensional model of NO transport in a cross section of the inner stripe (IS) of the rat outer medulla to determine whether tubular and vascular generation of NO re...

摘要：【摘要】 In addition to forming the selective filtration barrier for the renal glomerulus, podocytes maintain glomerular capillary architecture by opposing distending hemodynamic forces。 To u...

摘要：【摘要】 We recently identified a novel phosphorylation site, serine-261 (pS261), in the COOH-terminus of the vasopressin-regulated water channel, aquaporin-2 (AQP2)。 To address whether phosp...

摘要：【摘要】 Plasma membrane monoamine transporter (PMAT) is a novel membrane transporter recently cloned and characterized in our laboratory。 We previously demonstrated that PMAT functions as a ...

摘要：【摘要】 Glomerular podocytes are critical regulators of glomerular permeability via the slit diaphragm and may play a role in cleaning the glomerular filter。 Whether podocytes are able to en...

摘要：【摘要】 The transient receptor vanilloid-4 (TRPV4) is a mechanosensitive, swell-activated cation channel that is abundant in the renal distal tubules。 Immunolocalization studies, however, pr...

摘要：【摘要】 In uremia, muscle wasting involves increased glucocorticoid production and activation of the ubiquitin-proteasome proteolytic pathway, including increased expression of ubiquitin。 Pr...

摘要：【摘要】 Normal rat pregnancy is characterized by plasma volume expansion due to renal sodium retention and is associated with a blunted response to natriuretic stimuli, such as atrial natriur...

摘要：To examine whether blood pressure (BP) differences correlated with the time course of glomerulosclerosis (GS), BP was measured continuously throughout the course by radiotelemetry in control ( n = ...

摘要：【摘要】 To clarify the role of noradrenergic pathways in preventing stress urinary incontinence (SUI) during sneezing, we investigated the effect of the norepinephrine reuptake inhibitor niso...

摘要：【摘要】 We have previously shown that K + -selective TASK2 channels and swelling-activated Cl - currents are involved in a regulatory volume decrease (RVD。 The aim of this study was to deter...

摘要：【摘要】 We tested the hypothesis that AMP-activated protein kinase (AMPK), an energy sensor, regulates diabetes-induced renal hypertrophy。 In kidney glomerular epithelial cells, high glucose...

摘要：【摘要】 Proximal tubular pressure shows periodic self-sustained oscillations in normotensive rats but highly irregular fluctuations in spontaneously hypertensive rats (SHR)。 Although we have...

摘要：【摘要】 Fetuin-A is a known inhibitor of vascular calcification in vitro。 However, vascular smooth muscle cells (VSMC) do not synthesize fetuin-A, suggesting fetuin-A may be endocytosed to e...

摘要：Functional characterization suggested that an oppositely directed H + gradient serves as a driving force for the transport of a prototypical organic cation, tetraethylammonium, by MATE1, but there ...

摘要：【摘要】 Leptospirosis is a public health problem worldwide。 Lung edema clearance is largely affected by active sodium transport out of the alveoli rather than by reversal of the Starling for...

摘要：【摘要】 Insulin receptors are widely distributed in the kidney and affect multiple aspects of renal function。 In the proximal tubule, insulin regulates volume and acid-base regulation throug...

摘要：Integrins mediate cell-extracellular matrix interaction and may play a role tubular epithelial injury。 Murine primary tubular epithelial cells (TECs) express 5 -integrin, a fibroblast marker and t...

摘要：【摘要】 The kidney plays a major role in acid-base homeostasis by adapting the excretion of acid equivalents to dietary intake and metabolism。 Urinary acid excretion is mediated by the secre...

摘要：【摘要】 The epithelial Ca 2+ channel TRPV5 serves as a gatekeeper for active Ca 2+ reabsorption in the distal convoluted tubule and connecting tubule of the kidney。 WNK4, a protein serine/th...