摘要：【摘要】 The Na + /K + /2Cl - cotransporter (NKCC) plays diverse roles in the kidney, contributing sodium reabsorption and tubuloglomerular feedback (TGF)。 In the present study, we investigat...

摘要：O 2 - production increases in response to increased ion delivery in thick ascending limbs (TALs) and macula densa and mechanical strain in other cell types。 We hypothesized that increasing luminal...

摘要：, high NaCl) activates the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein (TonEBP/OREBP), increasing transcription of protective genes。 In the present s...

摘要：【摘要】 Single injection of a small quantity of phenol into the cortex of one kidney in rats results in development of persistent hypertension (HTN) which is thought to be mediated by activat...

摘要：【摘要】 High-conductance (BK or maxi) K + channels were observed in cell-attached patches of the apical membrane of the isolated split-open rat connecting tubule (CNT)。 These channels were q...

摘要：【摘要】 Aquaporin (AQP7) is expressed in proximal tubules and is involved in glycerol uptake。 AQP7 knockout (KO) mice were generated and used for immunohistochemical analyses to define the o...

摘要：【摘要】 Congenital urinary tract obstruction is the most important cause of renal insufficiency in infants and children, and angiotensin-converting enzyme (ACE) inhibitors attenuate the progr...

摘要：【摘要】 Autosomal dominant polycystic kidney disease (ADPKD) gene products polycystin-1 (PC1) and polycystin-2 (PC2) colocalize in the apical monocilia of renal epithelial cells。 Mouse and h...

摘要：【摘要】 Previously, we showed that neonatal induced chronic partial unilateral ureteral obstruction (PUUO) of the multipapillary pig kidney decreased glomerular filtration rate (GFR) of the o...

摘要：【摘要】 Pendrin ( Slc26a4 ) localizes to type B and non-A, non-B intercalated cells in the distal convoluted tubule, the connecting tubule, and the cortical collecting duct (CCD), where it me...

摘要：【摘要】 Matrix metalloproteinases (MMPs) are a large family of proteinases that remodel extracellular matrix (ECM) components and cleave a number of cell surface proteins。 MMP activity is re...

摘要：In the present study, we first investigated the effects of PGE 2 along the preglomerular vascular tree and subsequently focused on proximal interlobular arteries (ILAs)。 Endothelium removal and pr...

摘要：Warm ischemia (WI) is a crucial factor of tissue damage, and tissue destruction led by ischemia-reperfusion (I/R) can impact the early and long-term functional outcome。 Previously, we already veri...

摘要：【摘要】 The Ca 2+ -sensing receptor (CaR), a G protein-coupled receptor, is expressed in many epithelial tissues including the parathyroid glands, kidney, and GI tract。 Although its role in ...

摘要：【摘要】 This study examined the origin of spontaneous activity in neonatal and adult rat bladders and the effect of stretch and muscarinic agonists and antagonists on spontaneous activity。 R...

摘要：【摘要】 It has been shown that store-operated Ca 2+ influx (SOC) plays critical roles in the activation of endothelial nitric oxide (NO) synthase (eNOS) and generation of NO in endothelial ce...

摘要：【摘要】 Lower urinary tract function is regulated by spinal and supraspinal reflexes that coordinate the activity of the urinary bladder and external urethral sphincter (EUS)。 Two types of E...

摘要：Functionally UFF is in most cases characterized by an enhanced peritoneal mass transfer area coefficient for glucose (PS g ) combined with a largely unchanged peritoneal glucose osmotic conductance...

摘要：【摘要】 The PTH receptor (PTH1R) activates multiple signaling pathways, including extracellular signal-regulated kinases 1 and 2 (ERK1/2)。 The role of epidermal growth factor receptor (EGFR)...

摘要：【摘要】 The mouse kidney expresses the gene of ornithine aminotransferase ( Oat )。 Previous works suggest that Oat is differentially expressed in female and male mouse kidney (Alonso E, Rubi...

摘要：【摘要】 The effects of an acute increase in intraureteral pressure (IUP) on pelvic-urethra reflex potentiation were examined in urethane-anesthetized rats by recording the external urethral s...