摘要:Isolation of urinary exosomes by the established ultracentrifugation method has some limitations for use in a clinical laboratory。 We sought a rapid and simple way to obtain urinary exosomes。 We ...
08-07-04摘要:【摘要】 Pseudohyponatremia is a clinical condition characterized by an increased fraction of protein or lipid in plasma, thereby resulting in an artificially low plasma sodium concentration (...
08-07-04摘要:Renal tissue water content, renal tissue oxygenation (in relation to the magnetic resonance spin-spin relaxation rate), the apparent diffusion coefficient (ADC) of water, and volume of renal blood ...
08-07-04摘要:【摘要】 Atrial natriuretic peptide (ANP) and B-type natriuretic peptide decrease blood pressure and cardiac hypertrophy by activating natriuretic peptide receptor A (NPR-A), a transmembrane g...
08-07-04摘要:We demonstrated previously that mesenchymal stem cells (MSC), unlike fibroblasts, are significantly renoprotective after ischemia-reperfusion injury and concluded that this renoprotection is mediat...
08-07-04摘要:【摘要】 Levels of the type IIa Na/P i (Na/Pi-IIa) cotransporter, which serves as the principal mediator of phosphate reabsorption in the kidney, can be modulated through posttranscriptional o...
08-07-04摘要:【摘要】 Kidney proximal tubules develop a severe but highly reversible energetic deficit due to nonesterified fatty acid (NEFA)-induced dissipation of mitochondrial membrane potential ( m ) d...
08-07-04摘要:【摘要】 Ischemic acute renal failure (iARF) was described to reduce renal extraction of the organic anion para -aminohippurate (PAH) in humans。 The rate-limiting step of renal organic anion ...
08-07-04摘要:【摘要】 Renal dopamine, synthesized by proximal tubules, plays an important role in the regulation of renal sodium excretion。 Although the renal dopaminergic system has been extensively inve...
08-07-04摘要:【摘要】 Human organic cation transporter 2 (hOCT2) is essential for the renal tubular secretion of many toxic organic cations。 Previously, of the cysteines (C437, C451, C470, and C474) that ...
08-07-04摘要:【摘要】 Cultured podocytes easily lose expression of nephrin。 In this report, we developed optimum media for recovery and maintenance of nephrin gene expression in murine podocytes。 Using r...
08-07-04摘要:【摘要】 We have previously shown that in afferent arterioles, angiotensin II (ANG II) involves activation of the inositol trisphosphate receptor (IP 3 R), activation of adenine diphosphoribos...
08-07-04摘要:In the Munich ethylnitrosourea (ENU) mouse mutagenesis project, which is done on a C3H inbred genetic background, blood samples of more than 15,000 G1 offspring and 500 G3 pedigrees were screened f...
08-07-04摘要:【摘要】 The purpose of this study was to determine the accuracy and sources of error in estimating single-kidney glomerular filtration rate (GFR) derived from low-dose gadolinium-enhanced T1-...
08-07-04摘要:This study was aimed at investigating the role of extracellular ATP (eATP) in mediating apoptosis in human mesangial cells (HMC) and identifying the subtype(s) of purinergic receptors involved。 eA...
08-07-04摘要:【摘要】 MAK-V/Hunk is an SNF1-related serine/threonine kinase which was previously shown to be highly expressed in the mammary gland and central nervous system。 In this study, we found MAK-V...
08-07-04摘要:【摘要】 Aldosterone and angiotensin II (ANG II) contribute to the development and progression of renal damage。 Here we investigated the effects of bone morphogenetic proteins (BMPs) on renal...
08-07-04摘要:Even though the identities of the components involved in this ion transport across the mosquito Malpighian tubule epithelia have not been completely determined, electrophysiological studies suggest...
08-07-04摘要:【摘要】 The idea that an osmotically inactive Na + storage pool exists that can be varied to accommodate states of Na + retention and/or Na + loss is controversial。 We speculated that consid...
08-07-04摘要:Urea plays an important role in the urinary concentrating mechanism and expression of the urea transporters UT-A1, UT-A2, UT-A3, UT-A4, and UT-B is essential for tubular urea reabsorption。 The pre...
08-07-04摘要:【摘要】 We have previously demonstrated that transforming growth factor- 1 (TGF- 1 ) rapidly activates the mitogen-activated protein kinase kinase 3 (MKK3)-p38 MAPK signaling cascade, leading...
08-07-04摘要:Proximal tubular epithelial cells (PTECs), when exposed to albumin produce matrix proteins, proinflammatory and profibrotic cytokines like TGF- 1。 Some of these effects are dependent on endocytosi...
08-07-04摘要:【摘要】 This study evaluated in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) the response to salt loading of the renal dopaminergic system and transcript abundance of Na ...
08-07-04摘要:Although it is generally assumed that NO moves from cell to cell by free diffusion, we recently showed that aquaporin-1 (AQP-1) transports NO across cell membranes。 AQP-1 is expressed in endotheli...
08-07-04摘要:【摘要】 Previous studies propose 20-hydroxyeicosatetraenoic acid (20-HETE), a major arachidonic acid metabolite of cytochrome P -450 (CYP), as a possible mediator of Na + -K + -ATPase inhibit...
08-07-04摘要:Elevated levels of ANG II, the active peptide of the renin-angiotensin system, regulating blood pressure and cardiovascular homeostasis, are known to cause hypertension and kidney diseases。 There ...
08-07-04摘要:【摘要】 Vasopressin V 1a and V 2 receptors (V 1a R and V 2 R, respectively) distribute in the collecting duct of the kidney。 In the present study, we have investigated the role of the V 1a R...
08-07-04摘要:【摘要】 Regulatory volume decrease (RVD) occurs after hypotonicity-caused cell swelling。 RVD is caused by activation of ion channels and transporters, which cause effluxes of K +, Cl -, and ...
08-07-04摘要:【摘要】 Chronic kidney disease is accompanied by nitric oxide (NO) deficiency and oxidative stress, which contribute to progression。 We investigated whether the antioxidant vitamin E could p...
08-07-04摘要:【摘要】 Our aim was to determine whether fractionation of human urine affects the attachment of calcium oxalate monohydrate (COM) crystals to renal cells。 Attachment of [ 14 C]COM crystals t...
08-07-04摘要:【摘要】 We previously demonstrated that extracellular calcium regulates vitamin D receptor (VDR) expression by parathyroid cells。 Since the calcimimetic R-568 potentiates the effects of calc...
08-07-04摘要:【摘要】 Experiments were performed to establish the pharmacological profile of purinoceptors and to identify the signal transduction pathways responsible for increases in intracellular calciu...
08-07-04摘要:Lesion formation was preceded by mast cell trafficking to the lamina propria, and trafficking was mediated by tumor necrosis factor- (TNF)。 Here, we found that supernatants of TNF-treated urotheli...
08-07-04摘要:【摘要】 Acute renal failure (ARF) is a clinical syndrome characterized by deterioration of renal function over a period of hours or days。 Transcriptional responses to hypoxia can be inflamma...
08-07-04摘要:【摘要】 Ischemia followed by reperfusion is a major cause for renal injury in both native kidney and renal allografts。 In this study, we investigated the role of Hcy in ischemia-reperfusion-...
08-07-04摘要:【摘要】 Pendred syndrome, characterized by childhood deafness and postpuberty goiter, is caused by mutations of SLC26A4, which codes for the anion exchanger pendrin。 The goal of the present ...
08-07-04摘要:Mutations of AQP2 gene in humans cause both recessive and dominant nephrogenic diabetes insipidus (NDI), a disease in which the kidney is unable to concentrate urine in response to vasopressin。 In...
08-07-04摘要:Recently, we demonstrated that 24 h of BUO is associated with increased cyclooxygenase (COX)-2 expression in the inner medulla (IM) and that selective COX-2 inhibition prevents downregulation of AQ...
08-07-04摘要:【摘要】 The low Ca 2+ concentration ([Ca 2+ ]) of mammalian endolymph in the inner ear is required for normal hearing and balance。, Biochem Biophys Res Commun 331: 1353-1357, 2005) that the ...
08-07-04摘要:【摘要】 The vasopressin type 2 receptor (V2R) is a G protein-coupled receptor that plays a central role in renal water reabsorption。 Termination of ligand (vasopressin) stimulation is an imp...
08-07-04