摘要：【摘要】 Glomerular filtration rate (GFR), which measures the amount of plasma filtered through the kidney within a given time, is an essential and clinically important indicator of kidney fun...

摘要：【摘要】 Superoxide (O 2 - ) enhances tubuloglomerular feedback by scavenging nitric oxide at the macula densa。 However, the singling pathway of O 2 - production in the macula densa is not kn...

摘要：【摘要】 Transgenic rats with inducible ANG II-dependent malignant hypertension [TGR(Cyp1a1Ren2)] were generated by inserting the mouse Ren2 renin gene into the genome of the rat。 The present...

摘要：【摘要】 Proteinuria is pathogenic to proximal tubular cells (PTC) and linked with progression to renal failure。 The aim of this study was to determine the effects of human serum albumin (HSA...

摘要：【摘要】 To investigate the hypothesis that Na + concentration in subplasmalemmal microdomains regulates Ca 2+ concentrations in cellular microdomains ( md ), the cytosol ( cyt ), and sarcopla...

摘要：【摘要】 Human organic anion transporter 1 (OAT1, SLC22A6), which is localized to the basolateral membranes of renal tubular epithelial cells, plays a critical role in the excretion of anionic...

摘要：We investigated the effect of hydrochlorothiazide (H), alone or combined with losartan (L), in the 5/6 renal ablation model (Nx)。 Both H and L attenuated hypertension, whereas combined L+H treatme...

摘要：To understand more about this delicate barrier, we studied the functional and morphological effects of mild (15 min) renal ischemia-reperfusion injury (IRI)。 Renal function was studied in rats in ...

摘要：【摘要】 The current study investigates whether the spinal pelvic nerve-to-external urethra sphincter (EUS) reflex potentiation can be induced by a mechanical stimulation and whether the gluta...

摘要：【摘要】 The role of cyclooxygenase 2 (COX-2) in the control of renin is still a matter of debate, since studies with COX-2-deficient mice or with COX-2 inhibitors produced conflicting finding...

摘要：The pathophysiological mechanisms may involve apoptosis and the renin-angiotensin system。 We studied apoptosis and fibrosis in a well-established neonatal pig model with unilateral partial uretera...

摘要：【摘要】 FTY720 is a novel immune modulator whose primary action is blood lymphocyte depletion through interaction with sphingosine-1-phosphate (S1P) receptors。 The present study analyzes the...

摘要：【摘要】 Adult-onset calorie restriction (A-CR) is an experimental model of life extension and healthy aging less explored, compared with calorie restriction begun at early ages, but one more ...

摘要：【摘要】 Serum and glucocorticoid regulated kinase 1 (SGK1) has been identified as a key regulatory protein that controls a diverse set of cellular processes including sodium (Na + ) homeostas...

摘要：【摘要】 Extracellular ATP initiates potent effects on sodium transport across renal epithelia through membrane-associated purinergic receptors。 Dependent on the location of these receptors, ...

摘要：【摘要】 Renal blood flow (RBF) can be reduced in rats and rabbits by up to 40% without significant changes in renal tissue P O 2。 We determined whether this occurs because renal oxygen consu...

摘要：【摘要】 The exclusive basolateral localization of the Na-K-ATPase in kidney epithelium is a critical aspect of nephron function。 It has been suggested that mislocalized delivery of the Na-K-...

摘要：【摘要】 Mcl-1 is an antiapoptotic member of the Bcl-2 family that plays an important role in cell survival。 We demonstrate that proteasome-dependent regulation of Mcl-1 plays a critical role...

摘要：【摘要】 Furosemide administration stimulates distal acidification。 This has been attributed to the increased lumen-negative voltage in the distal nephron, but the aspect of regulatory mechan...

摘要：【摘要】 High ambient glucose activates intracellular signaling pathways to induce the expression of extracellular matrix and cytokines such as connective tissue growth factor (CTGF)。 Cell re...

摘要：To test the hypothesis that rising androgen levels at puberty permit diabetic kidney damage, we studied four groups of male rats with and without streptozocin-induced DM: adult onset (A), adult ons...

摘要：【摘要】 During renal ischemia-reperfusion (I/R) injury, apoptosis has been reported as a very important contributor to final kidney damage。 The determinant role of cytoskeleton derangement i...

摘要：【摘要】 In many forms of experimental kidney diseases, renal VEGF is low, and administering VEGF can be shown to be protective。 A paradox occurs in diabetes, in which renal VEGF levels are h...