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Public Health Sciences
Fred Hutchinson Cancer Research Center
Seattle, WA 98109
E-mail: iking{at}fhcrc.org
Dear Sir:
We thank Phinney for his interest in our recently published study (1). Phinney predicted an increase in fasting total serum triacylglycerol in the group randomly assigned to the low-fat diet in our feeding trial of isocaloric low-fat, high-carbohydrate and moderate-fat, low-carbohydrate diets. We measured total serum triacylglycerol at baseline and at the end of the study and found an average 10% increase in triacylglycerol from baseline in the low-fat diet group. A manuscript including these results is in preparation.
Because the increase in saturated fatty acids, particularly palmitic acid (16:0), in cholesterol esters and plasma phospholipids likely resulted from endogenous biosynthesis from carbohydrates, we may infer that the proportion of palmitic acid in triacylglycerol did increase, as suggested by Phinney. However, we did not measure the fatty acid composition of serum triacylglycerol to verify this possibility. Elevated serum triacylglycerol is a known risk factor for cardiovascular disease (2). The proposition that elevated saturated fatty acids, such as myristic acid or palmitic acid, in triacylglycerol may negate the possible cardiovascular benefits of low-fat diets is an interesting one and warrants further investigation.
ACKNOWLEDGMENTS
None of the authors had a personal or financial conflict of interest.
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