摘要：Angiotensin I is subsequently hydrolyzed by a peptidyl dipeptidase, angiotensin-converting enzyme (ACE), from the lung to form angiotensin II。 These included angiotensinogen, angiotensin I, angiot...

摘要：From the Institut für Kardiovaskulä。re Physiologie (K。K, R。P。B。, R。B。, I。F。), and Institut für Biochemie II (W。M。-E。), Klinikum der J。W。Goethe-Universitä。t, Frankfurt am Ma...

摘要：Calcineurin Aß。 Interestingly, calcineurin Aß。 Consistent with this observation, nuclear factor of activated T cells (NFAT)-luciferase reporter transgenic mice showed reduced expression...

摘要：21 In Vivo Surgical and Exercise ProtocolsPathological hypertrophy was induced by constriction of the transverse aortic arch。 NFAT-Luciferase Activity in Pathological HypertrophyAcute pressure ove...

摘要：proliferation IntroductionTopAbstractIntroductionMaterials and MethodsResultsDiscussionReferencesVascular smooth muscle cell (VSMC) proliferation, hypertrophy, and migration underlie most hypertro...

摘要：Mitochondrial respiration is an important source of ROS production and hence a potential contributor to cardiac reperfusion injury。 Complex I, also known as NADH-ubiquinone oxidoreductase, is a mu...

摘要：2,8,9 Contributions of GPCR Oligomerization to GPCR–G Protein InteractionsTopAbstractIntroductionBroad Evidence for GPCR。 Does Agonist-Mediated Dimerization/Oligomerization Occur, and Does It Re...

摘要：AbstractTopAbstractIntroductionMaterials and MethodsResultsDiscussionReerencesThe recently described hemoglobin scavenger receptor CD163 mediates the endocytosis of hemoglobin:haptoglobin (Hb:Hp) c...

摘要：Gene Expression of CYP Monooxygenases and Epoxide HydrolaseWe investigated gene expression of a total of 18 CYP isoforms in RNA extracts of HCAECs。 Enzyme Activity of CYP Monooxygenases (EROD and ...

摘要：ResultsTopAbstractIntroductionMaterials and MethodsResultsDiscussionReferencesSurvival of / MiceAs the colonies of mice aged, spontaneous deaths started to occur at 4 months of age and continued mo...

摘要：This Review is part of a thematic series on Mitochondrial Dysfunction in Ischemia, which includes the following articles:Role of the Mitochondrial Permeability Transition in Myocardial DiseasePrima...

摘要：Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart。 Connexin45 (6) expression delineates an extended conduction system in the embryoni...

摘要：Connexins can no longer be looked at as passive pores that allow ions to pass from one cell to the next。 Connexins are in many ways similar to scaffolding proteins that can bind cytoskeletal prote...

摘要：Rho-Kinase ActivityThe extent of ERM phosphorylation, as normalized by that of total actin, was significantly enhanced in the control allograft group compared with the isograft group 。 In Vivo Gen...