摘要：Abstract -Adrenergic receptors (AR) regulate active Na+ transport in the alveolar epithelium and accelerate clearance of excess airspace fluid。 Accumulating data indicates that the cystic fibrosis...

摘要：Abstract Ectopic calcification of blood vessels, heart valves, and skeletal muscle is a major clinical problem。 Angiogenesis may regulate ectopic calcification in several ways。 Key Words: pericyt...

摘要：Abstract To examine whether excessive protein O-GlcNAcylation plays a role in the dysfunction of the diabetic heart, we delivered adenovirus expressing O-GlcNAcase (Adv-GCA) into the myocardium of ...

摘要：Abstract RhoA plays a critical role in regulating NO production in cultured endothelial cells。 To determine its role in in situ endothelial cells, we investigated the effects of 3-hydroxy-3-methyl...

摘要：Abstract Atrial fibrillation is associated with increased expression of ventricular myosin isoforms in atrial myocardium, regarded as part of a dedifferentiation process。 Key Words: atrial fibrill...

摘要：The result of the present study now demonstrates an additional option: Progenitor cells can transiently “fuse“ to cardiomyocytes allowing the exchange of macromolecules via nanotubular structures。

摘要：Adipose tissue was the site where excess energy was stored, in the form of triglycerides (TGs), and where that energy, when needed elsewhere in the body, was released in the form of fatty acid (FA)...

摘要：These differences were not caused by differential activation of BMP signaling pathways because exogenous BMP-4 led to phosphorylation of Smad1, p38MAPK, and ERK1/2 in both cell types。 Conversely, ...

摘要：Abstract Vascular smooth muscle cells (VSMCs) express functional interleukin-18 receptors (IL-18Rs), composed of and subunits。 Because both IL-18 and Angiotensin II (Ang II) are implicated in athe...

摘要：Activation of p53 by Oxidative Stress Involves Platelet-derived Growth Factor-{beta} Receptor-mediated Ataxia Telangiectasia Mutated (ATM) Kinase Activation。

摘要：Microtubule Disruption Modulates Ca(2+) Signaling in Rat Cardiac Myocytes。 Cardiac excitation-contraction coupling。 Calcium-sensitive inactivation in the gating of single calcium channels。 Sarco...

摘要：Results Melusin Expression in Pressure Overloaded Hearts To investigate whether melusin expression is modified by pressure overload, WT were subjected to AB for different times。 Melusin expression...

摘要：Cardiovascular disease (CVD) is associated with elevated markers of systemic inflammation, including C-reactive protein (CRP) and members of the coagulation cascades。 Adipose Tissue Is a Mediator ...

摘要：Macrophage migration inhibitory factor (MIF) has recently been identified as a cardiac-derived myocardial depressant factor in septic shock。 Putative mechanisms by which MIF affects cardiac functi...

摘要：Abstract Caspase-1/interleukin-converting enzyme (ICE) is a cysteine protease traditionally considered to have importance as an inflammatory mediator, but not as an apoptotic effector。8eC10 Caspas...

摘要：Regulation of Myocardial Fibrillar Collagen by Angiotensin II。 Matrix metalloproteinases: pathways of induction by bioactive molecules。 Matrix metalloproteinase-9 and tissue inhibitor metalloprot...

摘要：) Tumor Microcirculation Group, Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex, UK (G。 Materials and Methods Rats and Tumors Seventy-four female Fischer 344 rats (Charles River...

摘要：The Molecular Cardiology (M。C。, B。C。, M。S。, M。R。, C。N。 S。G。P。) IRCCS Fondazione S。 Maugeri, Pavia, Italy the University of Pavia, Pavia (S。G。P。), Italy the Pathology Division (M。S...

摘要：Mutations Y17S, G21R, and A40V demonstrated a complete lack of functional electrical coupling even in the presence of significant plaque formation between paired cells。 Mutations in connexin prote...

摘要：Infection of endothelial cells (ECs) with first-generation E1/E3-deleted E4+ adenovirus (AdE4+) selectively modulates the survival and angiogenic potential of ECs by as of yet unrecognized mechanis...

摘要：Key Words: VSMC proliferation atherosclerosis NF-B PI3K MAPK Introduction Vascular smooth muscle cell (VSMC) proliferation and neo-intima formation are important events in the pathophysiological co...

摘要：The Vascular and Renal Research Laboratory (V。 Nuclear factor-B (NF-B) is important in the inflammatory response regulation。 The effector peptide of the renin angiotensin system Angiotensin II (A...

摘要：Histamine plays an important role in allergy, inflammation, neurotransmission, and gastrointestinal functions by acting via specific histamine receptors。10 Histamine also upregulates the gene expr...

摘要：Abstract Adenosine is a vascular endothelial cell mitogen, but anti-mitogenic for aortic smooth muscle cells and fibroblasts when acting via the A2B adenosine receptor。3 Adenosine, like many other...

摘要：This study addresses the effects of the Src family tyrosine kinase Fyn on NaV1。 Sodium currents were acquired by whole cell recording on HEK-293 cells transiently expressing NaV1。 Acute treatment...