摘要：Abstract Cardiac ischemia and reperfusion are associated with loss in the activity of the mitochondrial enzyme pyruvate dehydrogenase (PDH)。 Translocation of the redox-sensitive -isoform of protei...

摘要：Self-Assembly and Injectable Microenvironments One of the most important barriers to cardiac tissue engineering is that any new tissue must engraft into the already-diseased myocardium with electro...

摘要：We have recently created a soluble, stable and potent Ang1 variant, COMP-Ang1。 In the present study, we investigated the effects of varied dose and duration of COMP-Ang1 on vascular enlargement an...

摘要：Materials and Methods Cell Culture The human microvascular endothelial cell line, HMEC-1 (HMEC) and human umbilical vein endothelial cells (HUVEC) were cultured as previously described。 Semin Cell...

摘要：Abstract Vascular calcification is a common problem among the elderly and those with chronic kidney disease (CKD) and diabetes。 Key Words: bone morphogenetic proteins vascular calcification chroni...

摘要：Adenosine triphosphate (ATP) released from endothelial cells by shear stress and injury has been shown to protect the endothelial barrier in some settings。 Adenosine receptors also have been found...

摘要：Connective tissue growth factor (CTGF) is a novel fibrotic mediator that is overexpressed in human atherosclerotic lesions, myocardial infarction, and experimental models of hypertension。 In vascu...

摘要：the Molecular Medicine Program (C。L。, S。W。, A。D。, Z。S。K, N。M。C。), Division of Cardiovascular Diseases (C。L。, S。W。, A。D。, N。M。C。), Division of Nephrology (K。A。N), Department of...

摘要：In Vivo Expression of LOX-1 and LOXIN Isoforms To verify whether LOXIN transcript is indeed translated in vivo and to analyze the level of its expression, we used Western blot to examine the relati...

摘要：Effect of Chamber Anatomy on Shock-End Transmembrane Potential Distribution Within the 3-D Ventricular Volume In this section we elucidate the mechanisms underlying the change in vulnerability on r...

摘要：LOX-1 Overexpression Induces Intramyocardial Vasculopathy To evaluate the physiological consequence of LOX-1 overexpression, we examined the intramyocardial vasculopathy to determine any pathologic...

摘要：Results Effect of Acute ROCK Inhibition on Established Hypoxic Pulmonary Hypertension Mean peak right ventricular systolic pressure (RVSPpeak) measured during ventilation with 30% oxygen (53。 Chro...

摘要：hENT1 Expression hENT1 mRNA level was reduced in a concentration- and time-dependent manner by hypoxia (Figure 4A)。 eNOS Activity and Expression Hypoxia reduced L-citrulline formation compared wit...

摘要：Proteins were separated by 2-D gel-electrophoresis, detected by silver staining, and analyzed using Progenesis software。 Proteomic Analysis Protein extracts (100 e) of right ventricular endomyocar...

摘要：Canonical Wnt Pathway Is Activated Transiently Only During the Early Stage of Cardiomyocyte Differentiation To elucidate the molecular mechanisms of how PI3K/Akt pathway plays a critical role in ca...

摘要：the Robarts Research Institute (Vascular Biology Group) (E。v。d。V。, Z。N。, C。O。, J。G。P。) and London Health Sciences Centre (B。U。, D。F。, J。G。P。), Departments of Medicine (Cardiology)...

摘要：Abstract We have investigated the subcellular spontaneous Ca2+ events in canine Purkinje cells using laser scanning confocal microscopy。 Three types of Ca2+ transient were found: (1) nonpropagatin...

摘要：Abstract Heterocellular communication between vascular smooth muscle cells (VSMC) and endothelial cells (EC) at the myoendothelial junction (MEJ) is a critical part of control of the arteriolar wal...

摘要：Side population (SP) cells, characterized by a distinct Hoechst dye efflux pattern, have been shown to exist in multiple tissues and are capable of tissue-specific differentiation。 In this report,...

摘要：We show here that mice with deletion of the KCNQ1 protein partner KCNE1 have spontaneous episodes of atrial fibrillation despite normal atrial size and structure。 Whereas loss of KCNE1 function pr...

摘要：Expression of SERCA2 and Phospholamban Phosphorylation Hearts were frozen in liquid nitrogen and stored at eC80°C。 Troponin I isoform expression in human heart。 Expression of slow skeletal tropo...