摘要：The Na+eCCa2+ exchanger (NCX) is a key linker, through Ca2+ signaling, between contractility and arrhythmias。 Key Words: transmural-heterogeneity Na+eCCa2+ exchanger heart failure Introduction Sud...

摘要：Optical Setup The optical setup consisted of a high-frame-rate charge-coupled device video camera (12-bit digital。 Processing of Optical Recordings In all experiments, from 50 to 100 OAPs from eac...

摘要：Abstract Cardiac hypertrophy, a major determinant of morbidity and mortality in hypertrophic cardiomyopathy (HCM), is considered a secondary phenotype and potentially preventable。 Cardiac phenotyp...

摘要：Vascular remodeling was analyzed in a femoral artery injury and a blood flow cessation model in mice with a targeted deletion of the 18 carboxy-terminal intracellular amino acids of TF (TFct/ct) an...

摘要：Tissue factor (TF), a prothrombotic molecule expressed by various cell types within atherosclerotic plaques, is thought to play an essential role in thrombus formation after atherosclerotic plaque ...

摘要：Abstract Endothelial progenitor cells (EPCs) seem to be a promising tool for cell therapy of acute myocardial infarction, but their nature is still unclear。 We show here that EPCs obtainable from ...

摘要：Abstract Mutations in the human gene encoding the nucleotide-binding region in the -subunit of AMP-activated protein kinase (AMPK) cause cardiomyopathy with preexcitation syndrome。 Key Words: AMP-...

摘要：Protein kinase C- is responsible for the protection of preconditioning in rabbit cardiomyocytes。

摘要：the Department of Genetic Medicine (H。) and Belfer Gene Therapy Core Facility (N。 Key Words: angiogenesis thrombopoietin platelets megakaryocyte gene therapy Introduction Gene transfer of single ...

摘要：Quantitative Confocal Immunofluorescence Analysis of CelleCCell Junction Protein Expression Cultures were rinsed in serum-free medium and then fixed in 4% paraformaldehyde。 Results Stretch Increas...

摘要：Reactive Oxygen Species Measurements Dichlorofluoroscein Endothelium-denuded artery segments were incubated for 60 minutes at room temperature in HEPES-buffered PSS containing H2DCFDA (10 eol/L), f...

摘要：HDAC Targets in a Cardiomyocyte Cell Line To verify the fidelity of DCS, we randomly selected 38 DCS clones and quantified the corresponding genomic fragments in immunoprecipitates prepared from bo...

摘要：Surface expression is regulated by changes in gene expression,1eC3 interactions with accessory subunits, by phosphorylation, and by cellular components that regulate their trafficking to the cell s...

摘要：Abstract Peroxisome proliferatoreCactivated receptor (PPAR)- is required for adipogenesis but is also found in the cardiovascular system, where it has been proposed to oppose inflammatory pathways ...

摘要：Results Pharmacological Evidence for a CaSR in Mesenteric Artery Under control conditions ([Ca2+]o 1 mmol/L), myocyte resting membrane potential in endothelium-intact segments was eC53。 Pharmacolo...

摘要：Materials and Methods Measurement of Diameter and Endothelial Cell Calcium in Pressurized Arteries Male Wistar rats (Charles River。 Selective Endothelial Cell Loading of Cell-Impermeant Macromolec...

摘要：), University of Toronto, University Health Network, Canada Heart and Stroke/Richard Lewar Center of Excellence (G。 Timp-3eC/eC mice develop precipitous LV dilation and dysfunction reminiscent of ...

摘要：To test our hypothesis, we used a unique Cre/lox system to target the deletion of a floxed Alk3 allele, the type IA receptor for BMPs, to cardiac myocytes of the AV canal (AVC)。 When Alk3 was dele...

摘要：SERT and 5-HT Receptors Are Both Required for 5-HTeCInduced S100A4Mts1 Expression Human PA-SMC transfected with siRNA oligonucleotides targeting SERT reduced levels by 90% as measured by TaqMan RT-...

摘要：Results L-4F Inhibits the Binding of THP-1 Monocytes to Endothelial Cell Monolayers and Expression of Inflammatory Mediators LPS is a potent inducer of inflammatory markers including cytokines and ...

摘要：Results Colocalization of AR Subtypes in Cardiomyocytes To investigate possible intermolecular interactions between 1AR and 2AR subtypes, we expressed either or both AR subtypes in cultured ventric...

摘要：the Department of Physiology (S。D。, J。B。, F。H。, K。S。G。, D。M。B。), Loyola University Chicago, Maywood, Ill the University of Virginia (L。J。, A。L。T。), Charlottesville。 Abstract Cardi...

摘要：Gene Transfer with Ad。 Confirmation of Adenovirus Gene Transfer The expression of EGFP was used to confirm the efficacy of adenovirus infection。 Expression of nNOS and NO Production in the CBs fr...

摘要：Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)。 Serotonergic mechanisms in heart failure。