摘要:We investigated the role of the scaffolding protein Gab1 and the tyrosine phosphatase SHP2 in this signal transduction cascade in cultured and native endothelial cells。 Fluid shear stress elicited...
07-05-18摘要:Abstract Abnormal release of Ca from sarcoplasmic reticulum (SR) via the cardiac ryanodine receptor (RyR2) may contribute to contractile dysfunction and arrhythmogenesis in heart failure (HF)。 We ...
07-05-18摘要:Generation of Cysteine-Rich Protein 2eCDeficient Mice We generated Csrp2 (gene symbol for the mouse cysteine-rich protein gene)-deficient (Csrp2eC/eC) mice by gene targeting。 Absence of CRP2 Incre...
07-05-18摘要:Abstract Cytoplasmic overexpression of Akt in the heart results in a myopathy characterized by organ and myocyte hypertrophy。 Conversely, nuclear-targeted Akt does not lead to cardiac hypertrophy,...
07-05-18摘要:the Departments of Molecular Biology and Pharmacology (W。), Washington University Medical School, St Louis, Mo Department of Molecular and Cellular Physiology (W。 Abstract Previous studies have d...
07-05-18摘要:The serine-threonine kinase Akt has been shown to mediate IPC, and Akt activation is negatively regulated by the phosphatase PTEN, but whether PTEN activity is modulated by IPC has not been investi...
07-05-18摘要:Key Words: BK channel estradiol hypertension KCNMB1 gene cardiovascular risk sex age Introduction Hypertension is not only a disease but also the most prevalent risk factor for heart, brain, and ki...
07-05-18摘要:Abstract Adiponectin is an antiatherogenic adipokine that inhibits inflammation by mechanisms that are not completely understood。 Adiponectin decreased the secretion of IL-8 from human aortic endo...
07-05-18摘要:Preeclampsia is an inflammatory disorder where altered levels of vascular endothelial growth factor (VEGF) and the circulating soluble fms-like tyrosine kinase 1 (sFlt-1) have a pathogenic role。 V...
07-05-18摘要:Analysis of Reactive Products of Lipid Peroxidation T75 flasks of confluent HEK-293 cells were treated with 1 mmol/L t-BHP for 30 minutes at room temperature and then the oxidation reaction was que...
07-05-18摘要:TRPV4 message was detected in RNA from cerebral artery smooth muscle cells。 In patch-clamp experiments using freshly isolated cerebral myocytes, outwardly rectifying whole-cell currents with prope...
07-05-18摘要:Here, we have explored the expression of voltage-dependent K+ (Kv) channels in contractile (freshly dissociated) and proliferating (cultured) VSMCs obtained from human uterine arteries to establish...
07-05-18摘要:Abstract Cardiac-specific Na+eCCa2+ exchanger (NCX) knockout (KO) mice surprisingly survive into adulthood without compensatory changes in protein expression levels。 Key Words: excitationeCcontrac...
07-05-18摘要:The discovery of Epac as a guanine exchange factor (GEF), which is directly activated by cAMP, raises the question of the role of this protein in cardiac cells。 Here we show that Epac activation l...
07-05-18摘要:Abstract Phospholipase C (PLC) is a recently identified enzyme regulated by a wide range of molecules including Ras family small GTPases, Rho A, G12/13, and G with primary sites of expression in th...
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