摘要:Abstract The role of T-type Ca2+ channels for cardiovascular physiology, in particular blood pressure regulation, is controversial。 Selective blockade of T-type Ca2+ channels in resistance arterie...
07-05-18摘要:Hyaluronic acid (HA) generated by smooth muscle cells (SMC) is thought to augment the progression of atherosclerosis。 Differential Regulation of HAS1 and HAS3 Isoforms in Human Venous SMC The mRNA...
07-05-18摘要:Furthermore, although much is known about the detrimental role that the c-Jun N-terminal kinases (JNKs) play in promoting death of cells exposed to various stresses, little is known of the molecula...
07-05-18摘要:Abstract Disruption of leptin signaling is associated with obesity, heart failure, and cardiac hypertrophy, but the role of leptin in cardiac myocyte apoptosis is unknown。 We tested the hypothesis...
07-05-18摘要:Materials and Methods Model of Dyssynchronous Heart Failure The experimental model of cardiac dyssynchrony and heart failure was generated in canines via radiofrequency ablation of the LBB followed...
07-05-18摘要:Cardiomyocyte apoptosis was present at similar levels in the left and right atria, suggesting that factors in addition to cell death contributed to the differential atrial fibrosis。 Cardiomyocyte ...
07-05-18摘要:Abstract Raised levels of soluble P-selectin (sP-selectin) have been reported in the plasma of patients with vascular diseases。 Plasma Soluble P-Selectin Measurement Whole blood was taken from pat...
07-05-18摘要:Abstract Diabetic foot is caused by microangiopathy and is suggested to be a result of impaired angiogenesis。1 Diabetic foot is an intractable disease categorized by DM-related vascular complicati...
07-05-18摘要:), University of Texas Southwestern Medical Center, Dallas, Tex Lipoprotein and Atherosclerosis Research Group (Y。 Endothelial Cell Migration Assay BAECs were grown to near confluence, and a defin...
07-05-18摘要:-Catenin in turn binds -catenin and connects the AJ complex with the actin cytoskeleton。 Because EXD expression in endothelial cells activated the Rho GTPase Cdc42, we addressed its role in the me...
07-05-18摘要:Isolation of Cardiomyocytes Single ventricular myocytes were isolated from 7-week-old female Wistar rats as described previously。 Altering the Polymerization State of Microtubules To alter the pol...
07-05-18摘要:Abstract Arrhythmogenic cardiac ryanodine receptor (RyR2) mutations are associated with stress-induced malignant tachycardia, frequently leading to sudden cardiac death (SCD)。 Mutation-Linked Defe...
07-05-18摘要:Results Endothelial Cells Cocultured With Secretory Smooth Muscle Cells Support the Adhesion of Platelets in the Presence of TNF Unstimulated EC cultured in isolation or cocultured with SMC on poro...
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