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在线期刊
临床研究杂志
2003年第74卷第1期
A case of frontal network amnesia
Discrimination and delusional ideation
Evaluation of a community-based rehabilitation model for chronic schizophrenia in rural India
Impact of the ICD-10 Primary Health Care (PHC) diagnostic and management guidelines for mental disorders on detection and outcome in primary careCluster rando
Incidence of schizophrenia in south-east London between 1965 and 1997
Medical outcome of pregnancy in women with psychotic disorders and their infants in the first year after birth
Racial discrimination and mental illness
Trends in the use of Part II of the Mental Health Act 1983 in seven English local authority areas
2005年第115卷第1期
How to support the basic sciences
Bullets and bacilli The Spanish-American War and military medicine
Plague The mysterious past and terrifying future of the world’s most deadly disease
Regeneration of the pancreatic ? cell
A1 antagonism in asthma: better than coffee?
CaV2.3 channel and PKC: new players in insulin secretion
A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury
Stay tuned to PXR: an orphan actor that may not be D-structive only to bone
Mac the knife? Macrophages– the double-edged sword of hepatic fibrosis
SDF-1 tells stem cells to mind their P’s and Z’s
A new mechanism of BRAF activation in human thyroid papillary carcinomas
The promise of stem cells in Parkinson disease
Immune complexes as therapy for autoimmunity
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity
Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy
SDF-1 is both necessary and sufficient to promote proliferative retinopathy
Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer
Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model
Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors
2005年第115卷第2期
The mold in Dr. Florey’s coat The story of the penicillin miracle
Paget disease of bone
The great betrayal Fraud in science
MUNC-ing around with insulin action
Defining smooth muscle cells and smooth muscle injury
Birth pangs: the stressful origins of lymphocytes
Rab27a: a new face in ? cell metabolism-secretion coupling
Host-based antipoxvirus therapeutic strategies: turning the tables
Knock your SOCS off!
Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis
The unfolded protein response sensor IRE1 is required at 2 distinct steps in B cell lymphopoiesis
IL-1 mediates TNF-induced osteoclastogenesis
Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization
An affinity/avidity model of peripheral T cell regulation
Transcriptional activation of integrin ?6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma
HIV-1 clade promoters strongly influence spatial and temporal dynamics of viral replication in vivo
Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance
Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis
2005年第115卷第3期
Desperately seeking diversity
Tsunami threats: the long and short of it
NIH consulting ban a matter of ethics
The good, the bad, the mad cow
Weighing in on obesity‘s nature-versus-nurture debate
Sick to death and not going to take it anymore! Reforming health care for the last years of life
Consumed in the city Observing tuberculosis at century‘s end
Gestational diabetes mellitus
Learning from failure: congestive heart failure in the postgenomic age
Oxygen, oxidative stress, hypoxia, and heart failure
NO/redox disequilibrium in the failing heart and cardiovascular system
Genetic causes of human heart failure
Toward transcriptional therapies for the failing heart: chemical screens to modulate genes
Mitochondrial energy metabolism in heart failure: a question of balance
Altered intracellular Ca2+ handling in heart failure
Death begets failure in the heart
Protein kinase cascades in the regulation of cardiac hypertrophy
Unchain my heart: the scientific foundations of cardiac repair
Genetic mouse models of essential tremor: are they essential?
Illuminating the role of type I IFNs in colitis
2005年第115卷第4期
Sex and the university system
Taking a (mosquito) bite out of malaria
Long life still hard on the brain
NIH hopes to see more bang for the same buck
Nabel speaks up about directing the NHLBI
Darwinian heresies
Chemical consequences Environmental mutagens, scientist activism, and the rise of genetic toxicology
The several Cs of translational clinical research
Immunopathogenesis and therapy of cutaneous T cell lymphoma
Melanoma genetics and the development of rational therapeutics
The pathophysiology of autoimmune blistering diseases
To live or die: a critical decision for the lung
MEF2A sequence variants and coronary artery disease: a change of heart?
The fickle finger of fate
Altered regulation of IL-2 production in systemic lupus erythematosus: an evolving paradigm
In hypertension, the kidney is not always the heart of the matter
Ikaros transcription factors: flying between stress and inflammation
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury
Induction of dermal-epidermal separation in mice by passive transfer of antibodies specific to type VII collagen
An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression
2005年第115卷第5期
Isidore S. Edelman
Belgian scientists awarded top honors
Vaccine program rubs out rubella in the US
In the debate of sex and science, Summers, Hopkins, and the X chromosome battle it out
PETA continues to claw at Columbia scientists
Obsessive genius: The inner world of Marie Curie
The problem of biological weapons
The role of cerebral amyloid ? accumulation in common forms of Alzheimer disease
Inflammation, stress, and diabetes
Food for thought: endocannabinoid modulation of lipogenesis
Chemokine-mediated angiogenesis: an essential link in the evolution of airway fibrosis?
The role of hepatic insulin receptors in the regulation of glucose production
Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease
Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool
Caffey disease: an unlikely collagenopathy
A tax on luxury: HTLV-I infection of CD4+CD25+ Tregs
Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome
A seek-and-hide game between Cd1-restricted T cells and herpesviruses
Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment
Synaptopodin regulates the actin-bundling activity of -actinin in an isoform-specific manner
2005年第115卷第6期
Do you have NIH funding? Then read this.
Stanley J. Korsmeyer
Using genetics to unearth our path on earth
Coordinating cord blood efforts
The life sciences, according to Didier Trono
Bathsheba’s breast Women, cancer & history
DNA and the criminal justice system The technology of justice
Miscues on the “lack of MEF2A mutations“ in coronary artery disease
Response to Wang et al.
Mapping the new frontier: complex genetic disorders
Factors affecting statistical power in the detection of genetic association
Mapping quantitative trait loci in humans: achievements and limitations
Linkage disequilibrium maps and association mapping
Genetic epidemiology of diabetes
Finding schizophrenia genes
The genetic epidemiology of neurodegenerative disease
Atrial natriuretic peptide: an essential physiological regulator of transvascular fluid, protein transport, and plasma volume
Vascular endothelium is critically involved in the hypotensive and hypovolemic actions of atrial natriuretic peptide
Lessons learned from cancer may help in the treatment of pulmonary hypertension
Toward improved immunocompetence of adoptively transferred CD8+ T cells
2005年第115卷第7期
Open access jumps the pond
Stem cell division
Prominent investigator wins diabetes research award
The Proteus effect Stem cells and their promise for medicine
The ancestor’s tale A pilgrimage to the dawn of evolution
Payment of clinical research subjects
Entry of parainfluenza virus into cells as a target for interrupting childhood respiratory disease
Skeletal muscle fat oxidation: timing and flexibility are everything
HIF-1: a master regulator of innate host defenses?
Bone marrow plasticity revisited: protection or differentiation in the kidney tubule?
Harlequin ichthyosis unmasked: a defect of lipid transport
Chromogranin A: a surprising link between granule biogenesis and hypertension
Distinct mechanisms of TGF-?1–mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis
FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes
Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP
Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells
Intrarenal cells, not bone marrow–derived cells, are the major source for regeneration in postischemic kidney
Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer
Mutations in lipid transporter ABCA12 in harlequin ichthyosis and functional recovery by corrective gene transfer
Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells
2005年第115卷第8期
Tom Cruise is dangerous and irresponsible
A catalyst of the bioengineering field plans its farewell
New Annie and Willie Nelson Professor says award is music to his ears
Stopping stroke before it strikes
Message in a bottle The making of fetal alcohol syndrome
Splendid solution Jonas Salk and the conquest of polio
Thyrotropin receptor–associated diseases: from adenomata to Graves disease
The channelopathies: novel insights into molecular and genetic mechanisms of human disease
Inherited disorders of voltage-gated sodium channels
Muscle channelopathies and critical points in functional and genetic studies
Sodium channel mutations in epilepsy and other neurological disorders
Long QT syndrome: from channels to cardiac arrhythmias
Genetics of acquired long QT syndrome
Cardiac and skeletal muscle disorders caused by mutations in the intracellular Ca2+ release channels
Chloride channel diseases resulting from impaired transepithelial transport or vesicular function
ATP-sensitive potassium channelopathies: focus on insulin secretion
Of mice and men: the iron age
Akt1 in the cardiovascular system: friend or foe?
A new direction for gene therapy: intrathymic T cell–specific lentiviral gene transfer
Spring brings breezes, wheezes, and pollen oxidases
2005年第115卷第9期
New HIV vaccine center has Haynes at its helm
Parasite genome similarities offer hope for new drugs and vaccines
All eyes on the Nobel Prize
A machine to make a future Biotech chronicles
The price of smoking
The crucial role of macrophages in lymphangiogenesis
Anchors away: contribution of a glycolipid anchor to bacterial invasion of host cells
Mechanisms of sudden cardiac death
Searching for transcriptional regulators of Ang II–induced vascular pathology
Osteoblast-derived PTHrP is a physiological regulator of bone formation
Activation or anergy: NKT cells are stunned by -galactosylceramide
Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms
Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages
Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization
Organ-specific roles for transcription factor NF-B in reovirus-induced apoptosis and disease
Small-molecule correctors of defective F508-CFTR cellular processing identified by high-throughput screening
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1–34
ATP and purinergic receptor–dependent membrane traffic in bladder umbrella cells
2005年第115卷第10期
Don’t be stupid about intelligent design
Q & A with the man who can stop cervical cancer in its tracks
Nucleic acid sequence data turns 100,000,000,000 and looks to the future
In the quest to stymie time, will laboratory data stand up in man?
Testosterone dreams: Rejuvenation, aphrodisia, doping
Postcards from the brain museum: The improbable search for meaning in the matter of famous minds
Untying the Gordian knot: policies, practices, and ethical issues related to banking of umbilical cord blood
Kidney stone disease
Pharmacological manipulation of cell death: clinical applications in sight?
The survival kinases Akt and Pim as potential pharmacological targets
IKK/NF-B signaling: balancing life and death – a new approach to cancer therapy
Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways
Mitochondria: pharmacological manipulation of cell death
Pharmacological manipulation of Bcl-2 family members to control cell death
Endoplasmic reticulum stress: cell life and death decisions
Caspases: pharmacological manipulation of cell death
Mining yeast in silico unearths a golden nugget for mitochondrial biology
PDGF signaling in pulmonary arterial hypertension
Give me A5 for lipoprotein hydrolysis!
Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function
2005年第115卷第11期
UCLA director gets the goods as California makes good on its stem cell initiative
Displaced docs and researchers ride out the storm
Hope or hype:
Evolution in four dimensions:
B cells: no longer bystanders in liver fibrosis
CD36 may determine our desire for dietary fats
All neuropathies great and small
When 7 transmembrane receptors are not G protein–coupled receptors
Variable phenotypic expression of mutations in genes of the immune system
New insights into nNOS regulation of vascular homeostasis
Infiltration of COX-2–expressing macrophages is a prerequisite for IL-1?–induced neovascularization and tumor growth
Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling
Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction
A cancer-specific transcriptional signature in human neoplasia
Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine
GM-CSF action in the CNS decreases food intake and body weight
Cardiac-specific overexpression of AT1 receptor mutant lacking Gq/Gi coupling causes hypertrophy and bradycardia in transgenic mice
Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF-B decoy oligonucleotides
Attenuated liver fibrosis in the absence of B cells
BLyS and APRIL in rheumatoid arthritis
2005年第115卷第12期
Hopkins scientist tunes in to treat tuberculosis
Taking the direct route to make open access even easier
Fatal sequence:
Murderous medicine:
The L-type calcium channel in the heart: the beat goes on
Pathogenesis of osteoporosis: concepts, conflicts, and prospects
Did dinosaurs have megakaryocytes? New ideas about platelets and their progenitors
Megakaryocyte biology and related disorders
The molecular mechanisms that control thrombopoiesis
The biogenesis of platelets from megakaryocyte proplatelets
Thrombus formation in vivo
Structure and function of the platelet integrin IIb?3
Platelet genomics and proteomics in human health and disease
Platelets in inflammation and atherogenesis
Minding the gaps to promote thrombus growth and stability
Is ghrelin a signal for the development of metabolic systems?
New ways in which GLP-1 can regulate glucose homeostasis
Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases
Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin
Desperately seeking sugar: glial cells as hypoglycemia sensors
2006年第116卷第1期
Doctors from hell:
The dream of the perfect child
Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities
Taking a bite out of hypertrophic cardiomyopathy: soy diet and disease
Gene expression profiling gets to the root of human hair follicle stem cells
Delving deeper into MALT lymphoma biology
Serum peptidome for cancer detection: spinning biologic trash into diagnostic gold
Is the small heat shock protein B-crystallin an oncogene?
Inflamed fat: what starts the fire?
Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2
Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice
Uterine sensitization-associated gene–1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury
Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth
Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes
A new type of radiosensitive T–B–NK+ severe combined immunodeficiency caused by a LIG4 mutation
Reversing the defective induction of IL-10–secreting regulatory T cells in glucocorticoid-resistant asthma patients
Microchimerism maintains deletion of the donor cell–specific CD8+ T cell repertoire
ERK1/2 mitogen-activated protein kinase selectively mediates IL-13–induced lung inflammation and remodeling in vivo
cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas
Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo
2006年第116卷第2期
Radiation and modern life
Generation Rx
Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes
SIDS: genetic and environmental influences may cause arrhythmia in this silent killer
Gastrointestinal motility and glycemic control in diabetes: the chicken and the egg revisited?
Insulin’s effect on the liver: “Direct or indirect?“ continues to be the question
C5a and Fc receptors: a mutual admiration society
Mucus in chronic airway diseases: sorting out the sticky details
Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease
Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt
GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway
Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals
Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion
Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes
Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers
Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia
Lanosterol synthase mutations cause cholesterol deficiency–associated cataracts in the Shumiya cataract rat
Connexin43-dependent mechanism modulates renin secretion and hypertension
Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells
Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A
2006年第116卷第3期
Glowing genes
The Republican war on science
Going nuclear in metabolic and cardiovascular disease
Estrogen receptors and human disease
Sorting out the roles of PPAR in energy metabolism and vascular homeostasis
PPAR and human metabolic disease
PPAR: a dagger in the heart of the metabolic syndrome
Involvement of PPAR nuclear receptors in tissue injury and wound repair
Liver X receptors as integrators of metabolic and inflammatory signaling
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
An unexpected role for the anaphylatoxin C5a receptor in allergic sensitization
Going in circles: conserved mechanisms control radial patterning in the urinary and digestive tracts
Ghrelin receptor mutations — too little height and too much hunger
A unique role for Stat5 in recovery from acute anemia
A homing mechanism for bone marrow–derived progenitor cell recruitment to the neovasculature
Good news in the nuclear envelope: loss of lamin A might be a gain
Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling
Tbx18 regulates the development of the ureteral mesenchyme
Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling
Signals for stress erythropoiesis are integrated via an erythropoietin receptor–phosphotyrosine-343–Stat5 axis
2006年第116卷第4期
Rescuing the NIH before it is too late
Darwin An exhibition at the American Museum of Natural History
Twenty-first century plague
Harnessing preclinical mouse models to inform human clinical cancer trials
Childhood lead poisoning: the torturous path from science to policy
Adult T cell leukemia: a tale of two T cells
Cardiac 7-transmembrane-spanning domain receptor portfolios: diversify, diversify, diversify
Ontogeny of adrenal steroid biosynthesis: why girls will be girls
Pathomechanisms in rheumatoid arthritis — time for a string theory?
A new cardiac MASTer switch for the renin-angiotensin system
Oxidative stress in sepsis: a redox redux
The alchemy of tendon repair: a primer for the (S)mad scientist
Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators
Disease-associated mutations affect intracellular traffic and paracellular Mg2+ transport function of Claudin-16
Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis
Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance
Neotendon formation induced by manipulation of the Smad8 signalling pathway in mesenchymal stem cells
In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development
GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis
Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis
2006年第116卷第5期
James H. Schwartz
The new home for the JCI is . . .
In search of memory
The elements of murder
Why we think it is important to discuss intelligent design
Defending science education against intelligent design: a call to action
Nothing but skin and bone
Epidermal barrier formation and recovery in skin disorders
T cell control in autoimmune bullous skin disorders
Prophylactic human papillomavirus vaccines
Frontiers in pruritus research: scratching the brain for more effective itch therapy
The stem cell niches in bone
Estrogen deficiency and bone loss: an inflammatory tale
Regulation of bone mass by Wnt signaling
Receptor heterodimerization: a new level of cross-talk
An immunologic homunculus for type 1 diabetes
Bypassing complement: evolutionary lessons and future implications
The IL-23/IL-17 axis in inflammation
Role of caveolin-1 in the regulation of the vascular shear stress response
Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response
2006年第116卷第6期
Rescuing the NIH: the response
Response to: “Rescuing the NIH before it is too late“
Planning science (a generation after Lewis Thomas)
Response to: “Rescuing the NIH before it is too late“ from the Deputy Director for Extramural Research
Pain
Stem cell now
Cardiac hypertrophy: stressing out the heart
Mechanisms of sympathoadrenal failure and hypoglycemia in diabetes
IPEX and the role of FOXP3 in the development and function of human Tregs
Of mice, men, and elephants: Mycobacterium tuberculosis cell envelope lipids and pathogenesis
Probing the role of stearoyl-CoA desaturase_1 in hepatic insulin resistance
Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
Longitudinal noninvasive PET-based ? cell mass estimates in a spontaneous diabetes rat model
IL-15 induces CD4+ effector memory T cell production and tissue emigration in nonhuman primates
A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss
Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction
Autocrine PDGFR signaling promotes mammary cancer metastasis
SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1–dependent inflammatory arthritis
Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
2006年第116卷第7期
Stop misbehaving!
Power, sex, suicide
How fat works
Diagnosis and treatment of Parkinson disease: molecules to medicine
Insulin resistance and pancreatic ? cell failure
Central insulin action in energy and glucose homeostasis
Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony
AMP-activated protein kinase signaling in metabolic regulation
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Islet ? cell failure in type 2 diabetes
Insulin resistance and atherosclerosis
Tracking the recovery of consciousness from coma
Arrhythmogenic right ventricular cardiomyopathy: moving toward mechanism
Neuropeptide signaling and hydrocephalus: SCO with the flow
Liver X receptor opens a new gateway to StAR and to steroid hormones
New insights into the regulation of inflammation by adenosine
Lost and found: cardiac stem cell therapy revisited
Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
Liver X receptors regulate adrenal cholesterol balance
2006年第116卷第8期
Microbe
The baby business
The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap
Gout: new insights into an old disease
What’s in a name? eNOS and anaphylactic shock
HIV and CXCR4 in a kiss of autophagic death
Costimulation couture: a designer approach to regulating autoimmunity
Misbehaving macrophages in the pathogenesis of psoriasis
Tuning the oviduct to the anandamide tone
The glomerular basement membrane: not gone, just forgotten
Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation
Activated macrophages are essential in a murine model for T cell–mediated chronic psoriasiform skin inflammation
Resurrection of vitamin D deficiency and rickets
A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation
Fatty acid amide hydrolase deficiency limits early pregnancy events
Targeting tumor-associated macrophages as a novel strategy against breast cancer
Glucocorticoids suppress bone formation via the osteoclast
Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4
Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria
Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury
2006年第116卷第9期
Adaptive human regulatory T cells: myth or reality?
Cholesterol precursors and facial clefting
Toll-like receptors and IFN-: partners in autoimmunity
Regeneration of the endothelium as a novel therapeutic strategy for acute lung injury
A mighty mouse: building a better model of multiple sclerosis
Medical marvels
Pneumonia before antibiotics
Supporting junior faculty in the academic system: time for a change?
You say estren, I say estrogen. Let’s call the whole replacement off!
Deconstructing endothelial dysfunction: soluble guanylyl cyclase oxidation and the NO resistance syndrome
Endothelial cell–restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury
Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis
Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin
CD40 induces macrophage anti–Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes
Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation
The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1–/– mice
Myelin oligodendrocyte glycoprotein–specific T and B cells cooperate to induce a Devic-like disease in mice
Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+ /calmodulin-dependent protein kinase II
Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block
Role of IFN- in induction of Foxp3 and conversion of CD4+ CD25– T cells to CD4+ Tregs
2006年第116卷第10期
Response to Zhou et al.
The troubled dream of genetic medicine
Yellow fever
The physician-scientist, the state, and the oath: thoughts for our times
Deiodinases: implications of the local control of thyroid hormone action
T cell activation altersintestinal structure and function
Pili prove pertinent to enterococcal endocarditis
Imaging tumor angiogenesis
Myeloid suppressor cells regulate the adaptive immune response to cancer
To be or not to be B7
Children are not little adults: just ask their hematopoietic stem cells
Calcineurin/Nfat signaling is required for perinatal lung maturation and function
Rapid vascular regrowth in tumors after reversal of VEGF inhibition
Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid
Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis
Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation
Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice
Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model
Transcription factor MITF regulates cardiac growth and hypertrophy
Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo
2006年第116卷第11期
Can I quote you on that?
A man who has made his Marks on science
Response to Windahl et al.
The great stink of Paris and the nineteenth-century struggle against filth and germs
Book Review
Drug discovery in jeopardy
Myasthenia gravis: past, present, and future
Dysfunction of TGF-? signaling in Alzheimer’s disease
Microglia: a cellular vehicle for CNS gene therapy
Shaping the sperm head: an ER enzyme leaves its mark
The paradoxical patent ductus arteriosus
Role for IKK2 in muscle: waste not, want not
Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1–haploinsufficient osteoclast functions
Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism
Absence of bacterially induced RELM? reduces injury in the dextran sodium sulfate model of colitis
Role of different pathways of the complement cascade in experimental bullous pemphigoid
PLC2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2
Muscular atrophy of caveolin-3–deficient mice is rescued by myostatin inhibition
Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function
Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration
2006年第116卷第12期
In this issue
Robert H. Costa
HPV vaccine gets a shot in the arm
Response to Clark and Kupper
Response to Field
Molecular regulation of HDL metabolism and function: implications for novel therapies
RNAi: a novel strategy for the treatment of prion diseases
Search for the preadipocyte progenitor cell
Selectins revisited: the emerging role of platelets in inflammatory lung disease
Proinsulin: a unique autoantigen triggering autoimmune diabetes
The sticky truth about angiogenesis and thrombospondins
TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels
Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells
Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts
Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and Bcl2A1 as critical target genes
Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis
Proteasome-mediated degradation of IB and processing of p105 in Crohn disease and ulcerative colitis
Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice
Indoleamine 2,3-dioxygenase–expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection
医学百科App—中西医基础知识学习工具
栏目热点
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice
Protection against P. aeruginosa with an adenovirus vector containing an OprF epitope in the capsid
You are right too!
The physician-scientist, the state, and the oath: thoughts for our times
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