摘要：Columbia University College of Physicians and Surgeons, New York, New York, USA。eduIsidore S。 Edelman (affectionately known to friends and colleagues as Izzy) was a member of the post-war generat...

摘要：The Health Prize of the Interbrew-Baillet Latour Fund, worth nearly $200,000, is the most prestigious international scientific prize awarded in Belgium。 The JCI spoke with the scientists about the...

摘要：The remarkable contribution of vaccination programs to public health cannot be contested。 As a result of this prevention strategy, the devastating epidemics that plagued the country in the twentie...

摘要：While speaking at an academic conference on January 14, 2005, Lawrence Summers, the president of Harvard University, suggested that innate biological differences between men and women might be one ...

摘要：People for the Ethical Treatment of Animals (PETA) has been aggressively campaigning for animal rights since its inception in 1980, when its undercover investigation of a Maryland primate laborator...

摘要：Obsessive genius: the inner world of Marie Curie, a biography by Barbara Goldsmith, appears at a time when women are still underrepresented in most fields of science。 Why did she delay providing t...

摘要：comWhen letters containing anthrax spores were mailed within the United States in the fall of 2001, concerns about bioterrrorism mushroomed。 Anxiety was fueled in part by intelligence reports that...

摘要：AbstractFor approximately 80 years following Alzheimer’s description of the disease that bears his name, a gulf divided researchers who believed that extracellular deposits of the amyloid 。 pepti...

摘要：In this article, we discuss the molecular and cellular underpinnings of obesity-induced inflammation and the signaling pathways at the intersection of metabolism and inflammation that contribute to...

摘要：AbstractAn emerging body of evidence implicates peripheral and central endocannabinoid pathways in the regulation of feeding behavior and body weight。 A report in this issue of the JCI demonstrate...

摘要：demonstrate a role for CXC chemokine receptor 2 in the regulation of angiogenesis-mediated airway fibroproliferation。 Using bronchoalveolar lavage fluid from patients with pending or established b...

摘要：AbstractThe inability of insulin to suppress hepatic glucose production (HGP) is a key defect found in type 2 diabetes。 Two studies in this issue of the JCI demonstrate that selective changes in t...

摘要：AbstractNonalcoholic fatty liver disease (NAFLD) is a component of the metabolic syndrome, with a clinical spectrum ranging from simple fatty liver to steatohepatitis, cirrhosis, and hepatocellular...

摘要：AbstractCurrent models of T cell memory implicate a critical role for IL-7 in the effector-to-memory transition, raising the possibility that IL-7 therapy might enhance vaccine responses。 IL-7 has...

摘要：AbstractInfantile cortical hyperostosis (also known as Caffey disease) is characterized by hyperirritability, acute inflammation of soft tissues, and profound alterations of the shape and structure...

摘要：, who demonstrate that human T cell lymphotropic virus type I (HTLV-I) infection of CD4+CD25+ Tregs in patients with HTLV-I–associated myelopathy/tropical spastic paraparesis (HAM/TSP) results in ...

摘要：AbstractAngiogenesis and vascular remodeling support fibroproliferative processes。 however, no study has addressed the importance of angiogenesis during fibro-obliteration of the allograft airway ...

摘要：AbstractT and NK cells collaborate to control viral infections, discerning minute differences between infected and uninfected cells。See the related article beginning on page 1369 Recognition of vi...

摘要：1Departments of Cell Biology and Medicine, Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, New York, USA。2Laboratory of Pathology, National Cancer Institute, Bethesda...

摘要：AbstractSynaptopodin is the founding member of a novel class of proline-rich actin-associated proteins highly expressed in telencephalic dendrites and renal podocytes。 Synaptopodin-deficient (synp...

摘要：Center of Excellence in Vascular Biology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA。 AbstractTNF is essential for the developmen...

摘要：AbstractIn diabetic LDLR–/– mice, an ectopic BMP2-Msx2 gene regulatory program is upregulated in association with vascular calcification。 We verified the procalcific actions of aortic Msx2 expre...

摘要：Here we show that uncoupling of nitric oxide synthase–3 (NOS3) plays a major role in pressure load–induced myocardial ROS and consequent chamber remodeling/hypertrophy。 TAC induced NOS3 uncoupli...

摘要：Because the rate of NO generation from nitrite is linearly dependent on reductions in oxygen and pH levels, we hypothesized that nitrite would be reduced to NO in ischemic tissue and exert NO-depen...

摘要：AbstractA specific hypoglycosylated isoform of the complement regulator membrane cofactor protein (MCP。 Upon exposure of human spermatozoa to autologous serum or follicular fluid, we unexpectedly ...

摘要：AbstractInfantile cortical hyperostosis (Caffey disease) is characterized by spontaneous episodes of subperiosteal new bone formation along 1 or more bones commencing within the first 5 months of l...

摘要：AbstractSolute carrier family 11, member 2 (SLC11A2) is the only transmembrane iron transporter known to be involved in cellular iron uptake。 It is widely expressed and has been postulated to play...

摘要：We have found that the N-terminal lectin-like domain (D1) of TM has unique antiinflammatory properties。 TM, via D1, binds high-mobility group-B1 DNA-binding protein (HMGB1), a factor closely assoc...

摘要：AbstractThe kidney not only regulates fluid and electrolyte balance but also functions as an endocrine organ。 We hypothesized that the current understanding of the endocrine function of the kidney...

摘要：ABCA1 controls the rate-limiting step in HDL particle assembly by mediating efflux of cholesterol and phospholipid from cells to lipid-free apoA-I, which forms nascent HDL particles。 To determine ...

摘要：AbstractPseudomonas aeruginosa is an important opportunistic pathogen that can cause chronic and often life-threatening infections of the respiratory tract, particularly in individuals with cystic ...

摘要：AbstractCD36 mediates the transfer of fatty acids (FAs) across the plasma membranes of muscle and adipose cells, thus playing an important role in regulating peripheral FA metabolism in vivo。 In t...

摘要：AbstractEndogenous cannabinoids acting at CB1 receptors stimulate appetite, and CB1 antagonists show promise in the treatment of obesity。 CB1–/– mice are resistant to diet-induced obesity even t...

摘要：AbstractInsulin exerts its potent effects on hepatic glucose fluxes via direct and indirect mechanisms。 Whereas a liver-specific insulin receptor (IR) knockout (LIRKO) mouse exhibits glucose intol...

摘要：AbstractPartial restoration of insulin receptor Insr expression in brain, liver, and pancreatic 。 cells is sufficient for rescuing Insr knockout mice from neonatal death, preventing diabetes ketoa...

摘要：AbstractElevated plasma levels of VLDL triglycerides (TGs) are characteristic of patients with type 2 diabetes mellitus (T2DM) and are associated with increased production rates (PRs) of VLDL TGs a...

摘要：AbstractNonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess liver triacylglycerol (TAG), inflammation, and liver damage。 44 ± 10 years of age) scheduled for a ...

摘要：AbstractCD4+CD25+ Tregs are important in the maintenance of immunological self tolerance and in the prevention of autoimmune diseases。 As the CD4+CD25+ T cell population in patients with human T c...

摘要：To assess the specificity of these antibodies, we screened protein expression arrays containing 37,000 tagged proteins。 In both cases, we identified peptide sequences derived from EBV proteins exp...

摘要：AbstractLittle is known about the role of CD1d-restricted T cells in antiviral immune responses。 Here we show that the lytic replication cycle of the Kaposi sarcoma–associated herpesvirus (KSHV) ...