摘要：eduThis shocking first-hand account of the monstrous behaviors of Nazi physicians by Vivien Spitz should be required reading for all medical, dental, nursing, and public health students and faculty...

摘要：Joan RothschildIndiana University Press Bloomington, Indiana, USA。eduRecent advances in genetics and prenatal testing create the hope of children born free of the accidents of genetic roulette and...

摘要：(c) whether COX-2 inhibitors result in cardiovascular risk transformation during chronic dosing。 Mechanistic basis for a cardiovascular hazard resulting from inhibition of COX-2During the course o...

摘要：AbstractSome forms of hypertrophic cardiomyopathy (HCM) are caused by mutations in cardiac sarcomeric genes, but environmental factors are believed to influence the hypertrophic response。 A highly...

摘要：AbstractHair follicle stem cells sustain growth and cycling of the hair follicle and are located in the permanent portion of the follicle known as the bulge。 report the characterization of global ...

摘要：AbstractMucosa-associated lymphoid tissue (MALT) lymphomas can arise in a variety of extranodal sites。 Interestingly, at least 3 different, apparently site-specific, chromosomal translocations, al...

摘要：AbstractThe low molecular weight region of the serum peptidome contains protein fragments derived from 2 sources: (a) high-abundance endogenous circulating proteins and (b) cell and tissue proteins...

摘要：In this issue of the JCI, Moyano and colleagues further examine the oncogenic potential of the small heat shock protein -basic–crystallin, commonly expressed in tumors of the basal-like breast can...

摘要：When fed a high-fat diet (HFD), the macrophage-specific IKK。 Adipogenesis and angiogenesis are tightly linked during fat mass development (16, 17), and, like tumor growth, excessive growth of adip...

摘要：AbstractIn the face of systemic risk factors, certain regions of the arterial vasculature remain relatively resistant to the development of atherosclerotic lesions。 The biomechanically distinct en...

摘要：AbstractThe majority of acute clinical manifestations of atherosclerosis are due to the physical rupture of advanced atherosclerotic plaques。 It has been hypothesized that macrophages play a key r...

摘要：Although administration of large doses of bone morphogenetic protein–7 (BMP-7) has been shown to repair established renal injury and improve renal function, the pathophysiological role of endogeno...

摘要：AbstractInsulin receptor substrates, including Irs1 and Irs2, integrate insulin and IGF receptor signals with heterologous pathways to coordinate growth and metabolism。 Since Irs2 is thought to be...

摘要：AbstractUsing an siRNA-based screen, we identified the transcriptional corepressor RIP140 as a negative regulator of insulin-responsive hexose uptake and oxidative metabolism in 3T3-L1 adipocytes。...

摘要：A subset of T–B–NK+ SCID patients is sensitive to ionizing radiation, and the majority of these patients have mutations in Artemis。 We present a patient with a new type of radiosensitive T–B–N...

摘要：AbstractWe previously reported that human CD4+ Tregs secrete high levels of IL-10 when stimulated in the presence of dexamethasone and calcitriol (vitamin D3)。 We now show that following stimulati...

摘要：AbstractRare cases of stable allograft acceptance after discontinuation of immunosuppression are often accompanied by macrochimerism ( 1% donor cells in blood) or microchimerism ( 1% donor cells in...

摘要：AbstractIL-13 dysregulation plays a critical role in the pathogenesis of a variety of inflammatory and remodeling diseases。 In these settings, STAT6 is believed to be the canonical signaling molec...

摘要：AbstractThe pathogenesis of mucosa-associated lymphoid tissue (MALT) lymphomas is associated with independent chromosomal translocations that lead to the upregulation of either BCL10 or MALT1 or th...

摘要：Serum response factor (SRF) controls SMC gene transcription via binding to CArG box DNA sequences found within genes that exhibit SMC-restricted expression。 However, the mechanisms that regulate S...

摘要：AbstractMissense mutations in perforin, a critical effector of lymphocyte cytotoxicity, lead to a spectrum of diseases, from familial hemophagocytic lymphohistiocytosis to an increased risk of tumo...

摘要：AbstractAccumulation and aggregation of amyloid 。 is an effective way to prevent or treat AD, we compared the effects of passive immunization with an anti-A。42 mAb, an anti-A。1–16 mAbs。

摘要：AbstractDegeneration of peripheral motor axons is a common feature of several debilitating diseases including complicated forms of hereditary spastic paraplegia。 One such form is caused by loss of...

摘要：AbstractWe report that dietary modification from a soy-based diet to a casein-based diet radically improves disease indicators and cardiac function in a transgenic mouse model of hypertrophic cardi...

摘要：AbstractFocal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that plays a major role in integrin signaling pathways。 To circumvent these problems, we created mice in which FAK is selective...

摘要：AbstractEosinophils cluster around airway nerves in patients with fatal asthma and in antigen-challenged animals。 Activated eosinophils release major basic protein, which blocks inhibitory M2 musc...

摘要：AbstractEndothelial cells can protect cardiomyocytes from injury, but the mechanism of this protection is incompletely described。 Here we demonstrate that protection of cardiomyocytes by endotheli...

摘要：AbstractThe human hair follicle bulge is an important niche for keratinocyte stem cells (KSCs)。 Elucidation of human bulge cell biology could be facilitated by analysis of global gene expression p...

摘要：AbstractRecent gene profiling studies have identified a new breast cancer subtype, the basal-like group, which expresses genes characteristic of basal epithelial cells and is associated with poor c...

摘要：AbstractRecent studies have established distinctive serum polypeptide patterns through mass spectrometry (MS) that reportedly correlate with clinically relevant outcomes。 Using a highly optimized ...