摘要：AbstractThe feedback received regarding my recent editorial “Rescuing the NIH before it is too late“ has been fascinating to read。 The opinions expressed illustrate a huge divide between those i...

摘要：1Director, National Institute of Child Health and Human Development。2Acting Director, National Center for Research Resources。3Director, National Institute on Deafness and Other Communication Diso...

摘要：In no aspect of public life is the subversion of original science to bureaucratic need more evident than in the recent effort of the NIH, including its present director and the cadre he has enliste...

摘要：AbstractFor a number of reasons, the NIH and the biomedical research community are facing a period of fiscal constraint after pronounced growth。I would like to take this opportunity to respond to ...

摘要：Eliot ColeAmerican Society of Pain Educators, Montclair, New Jersey, USA。 E-mail: bc@paineducators。orgIt is not often that a book related to the field of pain comes along that requires me to stop...

摘要：eduChristopher Thomas Scott’s new book, Stem cell now: from the experiment that shook the world to the new politics of life, focuses on a timely topic and provides an excellent primer for understa...

摘要：AbstractThe question of what differentiates physiological from pathological cardiac hypertrophy remains one of the most clinically relevant questions in basic cardiovascular research。See the relat...

摘要：AbstractA reduced sympathoadrenal response, induced by recent antecedent hypoglycemia, is the key feature of hypoglycemia-associated autonomic failure (HAAF) and, thus, the pathogenesis of iatrogen...

摘要：AbstractGenetic defects in the transcription factor forkhead box protein P3 (FOXP3) cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX)。 IPEX is thought to be due to a def...

摘要：AbstractMycolic acids and structures attached to them constitute a major part of the protective envelope of Mycobacterium tuberculosis, and for this reason, their role in tuberculosis pathogenesis ...

摘要：AbstractPrevious studies using stearoyl-CoA desaturase–1–deficient (SCD1-deficient) mice have shown that this enzyme plays an important role in many diseases of altered cellular metabolism includ...

摘要：AbstractEctopic pancreas is a developmental anomaly occasionally found in humans。 Hes1, a main effector of Notch signaling, regulates the fate and differentiation of many cell types during develop...

摘要：AbstractAdipocytes secrete a variety of bioactive molecules that affect the insulin sensitivity of other tissues。 We now show that the abundance of monocyte chemoattractant protein–1 (MCP-1) mRNA...

摘要：cell mass (BCM) leading to insufficient insulin secretion and hyperglycemia。 However, serum insulin concentrations provide an imprecise index of BCM, and no reliable noninvasive measure of BCM is ...

摘要：AbstractHIV infection selectively targets CD4+ effector memory T (TEM) cells, resulting in dramatic depletion of CD4+ T cells in mucosal effector sites in early infection。 Regeneration of the TEM ...

摘要：AbstractActivating receptor activator of NF-B (RANK) and TNF receptor (TNFR) promote osteoclast differentiation。 A critical ligand contact site on the TNFR is partly conserved in RANK。 Surface pl...

摘要：AbstractFor over a century, there has been intense debate as to the reason why some cardiac stresses are pathological and others are physiological。 One long-standing theory is that physiological o...

摘要：Here we show that metastatic potential of oncogenic mammary epithelial cells requires an autocrine PDGF/PDGFR loop, which is established as a consequence of TGF-。–induced epithelial-mesenchymal t...

摘要：AbstractRA is an autoimmune disease characterized by sustained imbalance between pro- and antiinflammatory immune mechanisms。 The generation of Socs3–/vav mice, which lack SOCS-3 in the hematopoi...

摘要：AbstractIdentification of specific gene expression signatures characteristic of oncogenic pathways is an important step toward molecular classification of human malignancies。 In this study, we def...

摘要：4Center of Cardiology and Cardiovascular Surgery and5Department of Anatomy II, Experimental Morphology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany。 AbstractCarcinoembryonic anti...

摘要：AbstractActivation of latent TGF-。6 integrin is a critical step in the development of acute lung injury。6-mediated TGF-。 activation is regulated has not been identified。

摘要：AbstractTransfusion-related acute lung injury (TRALI) is the most common cause of transfusion-related mortality。 To explore the pathogenesis of TRALI, we developed an in vivo mouse model based on ...

摘要：AbstractFunctional and biochemical data have suggested a role for the cytochrome P450 arachidonate monooxygenases in the pathophysiology of hypertension, a leading cause of cardiovascular, cerebral...

摘要：We examined the role of H1R in allergic inflammation in vivo using a murine asthma model。 Despite this Th2 bias, allergen-challenged H1R–/– mice exhibited diminished lung Th2 cytokine mRNA level...

摘要：AbstractBronchial asthma, the most prevalent cause of significant respiratory morbidity in the developed world, typically is a chronic disorder associated with long-term changes in the airways。 We...

摘要：AbstractThe fungal pathogen Candida albicans has a multilayered cell wall composed of an outer layer of proteins glycosylated with N- or O-linked mannosyl residues and an inner skeletal layer of 。...

摘要：AbstractThe pathogenic fungus Cryptococcus neoformans infects humans upon inhalation and causes the most common fungal meningoencephalitis in immunocompromised subjects worldwide。 neoformans is fo...

摘要：AbstractRecent studies have shown that fine structural modifications of Mycobacterium tuberculosis cell envelope lipids mediate host cell immune activation during infection。 One such alteration in...

摘要：AbstractRegulation and dysregulation of intracellular calcium (Ca2+) signaling via the inositol 1,4,5-trisphosphate receptor (InsP3R) has been linked to many cellular processes and pathological con...

摘要：AbstractFailure to clear persistent viral infections results from the early loss of T cell activity。 A pertinent question is whether the immune response is programmed to fail or if nonresponsive T...

摘要：Mice with a targeted disruption of Scd1 gene locus are lean and display increased insulin sensitivity。 To examine whether Scd1 activity is required for the development of diet-induced hepatic insu...

摘要：AbstractThe balance between bioactivation and degradation of 1,25-dihydroxyvitamin D3 is critical for ensuring appropriate biological effects of vitamin D。 Cytochrome P450, family 24–mediated (CY...

摘要：AbstractThe autoimmune disease immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) is caused by mutations in the forkhead box protein P3 (FOXP3) gene。 In the mouse model of FOXP...

摘要：The corticotrophin-releasing factor (CRF) family of neuropeptides and their receptors (CRFR1 and CRFR2) play a critical role in regulating the neuroendocrine stress response。 Here we show in the S...

摘要：AbstractIn the vascular system, the receptor for the signaling molecule NO, guanylyl cyclase (GC), mediates smooth muscle relaxation and inhibition of platelet aggregation by increasing intracellul...

摘要：Original citation: J。 Clin。 Invest。 116::1360 –1370 (2006)。 doi:10。1172/JCI27030Citation for this corrigendum: J。 Clin。 Invest。 116::1738 (2006)。 doi:10。1172/JCI27030C1The label for the ...