摘要：AbstractJust as a simple phrase can become convoluted in the childhood game of Telephone, research findings can be distorted in the lay press。 The public primarily learns about medical research th...

摘要：Marks to science in New York City was held at Columbia University Medical Center in early September。 Both Columbia University and Memorial Sloan-Kettering Cancer Center (MSKCC) sponsored the sympo...

摘要：Division of Endocrinology Metabolism, Center for Osteoporosis Metabolic Bone Diseases, University of Arkansas for Medical Sciences and Central Arkansas Veterans Health Care System, Little Rock, A...

摘要：edu In August and September of 1880, all of Paris was suffused by an odor so putrid, so nauseating and fetid, that it sparked immediate fears of an epidemic, unfounded rumors of deaths throughout t...

摘要：New York, New York, USA。00 The Journal of Clinical Investigation, New York, New York, USA。

摘要：AbstractDespite striking advances in the biomedical sciences, the flow of new drugs has slowed to a trickle, impairing therapeutic advances as well as the commercial success of drug companies。 Red...

摘要：AbstractMyasthenia gravis (MG) is an autoimmune syndrome caused by the failure of neuromuscular transmission, which results from the binding of autoantibodies to proteins involved in signaling at t...

摘要：) in the brain is believed to trigger a complex and poorly understood pathologic reaction that results in the development of Alzheimer’s disease (AD)。 report that the expression of TGF-。RII) by ...

摘要：report that genetically modified hematopoietic precursor cells transduced to overexpress ARSA and transplanted into mice with a targeted disruption of the murine Arsa gene (Arsa–/– mice) migrated...

摘要：AbstractLipid storage diseases are debilitating inherited metabolic disorders that stem from the absence of specific lysosomal enzymes that degrade selected lipids。 describe the role of the ER-res...

摘要：AbstractThe ductus arteriosus (DA) is a vessel whose patency is required for fetal survival but is incompatible with postnatal life。 Because of developmental insufficiency, the DA in preterm infan...

摘要：AbstractActivation of transcription factor NF-B, the major regulator of the inflammatory response, depends on the inhibitor of NF-B kinase (IKK) complex, which is composed of 2 catalytic subunits, ...

摘要：AbstractIndividuals with neurofibromatosis type 1 (NF1) have a high incidence of osteoporosis and osteopenia。 Intercrossing Nf1+/– mice and mice deficient in class 1A PI3K (p85) restored elevated...

摘要：7K) is an inhibitor of TNF-induced apoptosis, but the molecular mechanism underlying this protective effect has not yet been explained exhaustively。 TNF-mediated apoptosis is initiated by ligand-i...

摘要：Interestingly, deletion of intestinal goblet cells protects against intestinal injury, suggesting that this epithelial cell lineage may produce molecules that exacerbate IBD。 (RELM。 also known as...

摘要：In the present study, we defined the roles of the different complement activation pathways in this model system。 Mice deficient in the classical pathway component complement component 4 (C4) and W...

摘要：PLC2, independent of PLC1, was required for receptor activator of NF-B ligand–induced (RANKL-induced) osteoclastogenesis by differentially regulating nuclear factor of activated T cells c1 (NFATc1...

摘要：Dominant-negative mutations of the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy 1C (LGMD1C) with loss of caveolin-3。 However, identification of the precise molecular mec...

摘要：AbstractAirway DCs play a crucial role in the pathogenesis of allergic asthma, and interfering with their function could constitute a novel form of therapy。 The sphingosine 1–phosphate receptor a...

摘要：AbstractNF-B is a major pleiotropic transcription factor modulating immune, inflammatory, cell survival, and proliferative responses, yet the relevance of NF-B signaling in muscle physiology and di...

摘要：AbstractThe transcription factor NF-B is an important regulator of homeostatic growth and inflammation。 Although gene-targeting studies have revealed important roles for NF-B, they have been compl...

摘要：AbstractNF-B2–deficient mice have impaired T and B cell responses。 We further demonstrated that NF-B2 was required for thymic Aire gene transcriptional regulation。 Engraftment of Nfkb2–/– thym...

摘要：-glucosidase acid 1 (GBA1) defective in subjects with the Gaucher’s form of lysosomal storage disease。 We conclude that GBA2 is a glucosylceramidase whose loss causes accumulation of glycolipids ...

摘要：AbstractProprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the proteinase K subfamily of subtilases that reduces the number of LDL receptors (LDLRs) in liver through an undefined ...

摘要：AbstractIFN- is known as the initial and primary inducer of immunoproteasomes during viral infections。 We now report that type I IFN induced the transcription and translation of immunoproteasome s...

摘要：AbstractTLR4 is the receptor for LPS and plays a critical role in innate immunity。 Stimulation of TLR4 activates proinflammatory pathways and induces cytokine expression in a variety of cell types...

摘要：Genetic disruption of the PGE-specific receptor EP4, however, paradoxically results in fatal patent DA (PDA) in mice。 Here we demonstrate that EP4-mediated signals promote DA closure by hyaluronic...

摘要：AbstractGenomic disorders are conditions that result from DNA rearrangements, such as deletions or duplications。 The identification of the dosage-sensitive gene(s) within the rearranged genomic in...

摘要：Here we show that the development of B cells, T cells, and myeloid cells was unaffected in CYLD-deficient mice, but that the activation of these cells with mediators of innate and adaptive immunity...

摘要：AbstractOverexpression of pituitary tumor–transforming 1 (PTTG1) is associated with thyroid cancer。 We found elevated PTTG1 levels in the thyroid tumors of a mouse model of follicular thyroid car...

摘要：AbstractAlzheimer’s disease (AD) is characterized by progressive neurodegeneration and cerebral accumulation of the 。 We report that the TGF-。 Reducing neuronal TGF-。 signaling in mice resulted...

摘要：AbstractMetachromatic leukodystrophy (MLD) is a demyelinating lysosomal storage disorder for which new treatments are urgently needed。 We previously showed that transplantation of gene-corrected h...

摘要：Original citation: J。 Clin。 Invest。 116:2208-2217 (2006)。 doi:10。1172/JCI28164 Citation for this corrigendum: J。 Clin。 Invest。 116:3083 (2006)。 doi:10。1172/JCI28164C1 During the preparati...