摘要：Spot the difference in proteasome compositionExcessive activation of NF-B is associated with the pathogenesis of both Crohn disease (CD) and ulcerative colitis (UC)。 Although CD and UC have many c...

摘要：Robert Costa died September 1, 2006, from complications of pancreatic cancer。 With Rob’s death we lost an outstanding scientist, a generous colleague, and a wonderful person。 I first met Rob in ...

摘要：Late September saw the Michigan Senate approve two bills that will require girls in Michigan entering the sixth grade to be vaccinated against the two strains of the sexually transmitted virus huma...

摘要：I read with great interest the commentary by Clark and Kupper titled Misbehaving macrophages in the pathogenesis of psoriasis (1) regarding our recently published articles in the JCI (2, 3)。First,...

摘要：We appreciate Michael Field’s opinion that based on our data, the concept of secretory diarrhea must be revised to include the idea that net water secretion, or diarrhea, can occur in the absence ...

摘要：AbstractHDL metabolism represents a major target for the development of therapies intended to reduce the risk of atherosclerotic cardiovascular disease。 HDL metabolism is complex and involves diss...

摘要：AbstractPrion disease refers to a group of fatal transmissible neurodegenerative diseases for which no pharmacological treatment is available。 The cellular prion protein (PrPC) is required for bot...

摘要：The identity and regulation of the adipocyte precursor cell (or preadipocyte) and the preadipocyte precursor cell (or progenitor cell) have been intensely studied for many years。 report that proge...

摘要：The emerging role of platelets may be of broad clinical relevance in lung inflammatory disorders, including asthma, chronic obstructive pulmonary disease, and cystic fibrosis。 The pathogenesis of ...

摘要：If self tolerance is broken autoimmune disease can develop, during which autoreactive lymphocytes are directed to a variety of autoantigenic epitopes。 However, researchers have yet to determine wh...

摘要：AbstractThe formation of new blood vessels, a process known as angiogenesis, is important for embryonic development and wound healing as well as the development of cancer and inflammation。 therefo...

摘要：AbstractThe heart responds to injury and chronic pressure overload by pathologic growth and remodeling, which frequently result in heart failure and sudden death。 Calcium-dependent signaling pathw...

摘要：AbstractIn heart failure (HF), Ca2+/calmodulin kinase II (CaMKII) expression is increased。 Calmodulin regulates Na+ channel gating, in part perhaps via CaMKII。 We investigated effects of adenovir...

摘要：Hence, studies aimed at better understanding SMC differentiation are of great importance。 Here, we report that multipotent adult progenitor cells (MAPCs) isolated from rat, murine, porcine, and hu...

摘要：To evaluate whether the vitamin D receptor (VDR) has a specific role in growth-plate development and endochondral bone formation, we investigated mice with conditional inactivation of VDR in chondr...

摘要：AbstractAnaplastic large cell lymphomas (ALCLs) represent a subset of lymphomas in which the anaplastic lymphoma kinase (ALK) gene is frequently fused to the nucleophosmin (NPM) gene。 Functional R...

摘要：AbstractBronchus-associated lymphoid tissue (BALT) was originally described as a mucosal lymphoid organ in the lungs of some species。 However, while the lungs of naive mice and humans typically la...

摘要：AbstractEnhanced NF-B activity is involved in the pathology of both forms of inflammatory bowel disease (IBD), Crohn disease (CD) and ulcerative colitis (UC)。 In line with this, we found enhanced ...

摘要：AbstractPrion diseases are fatal neurodegenerative diseases characterized by the accumulation of PrPSc, the infectious and protease-resistant form of the cellular prion protein (PrPC)。 We generate...

摘要：AbstractControl of pathogens by formation of abscesses and granulomas is a major strategy of the innate immune system, especially when effector mechanisms of adaptive immunity are insufficient。 We...

摘要：AbstractAcute lung injury (ALI) causes high mortality, but its molecular mechanisms are poorly understood。 We investigated the role of platelet-neutrophil interactions in a murine model of acid-in...

摘要：New adipocytes are believed to arise from resident adipose tissue preadipocytes and mesenchymal progenitor cells。 However, it is possible that progenitor cells from other tissues, in particular BM...

摘要：Altered expression and/or regulation of PDE3B may contribute to metabolic dysregulation, including systemic insulin resistance。 IntroductioncAMP plays critical roles in regulating energy metabolis...

摘要：In contrast, the role of Tr1 regulatory T cells, which secrete the antiinflammatory cytokine IL-10, in autoimmune disease has not been well assessed。 CD46 is a newly defined costimulatory molecule...

摘要：T cells specific for proinsulin and islet-specific glucose-6-phosphatase catalytic subunit–related protein (IGRP) can induce T1D in NOD mice。 As cytotoxic T cells specific for IGRP were not detec...

摘要：AbstractVision loss associated with ischemic diseases such as retinopathy of prematurity and diabetic retinopathy are often due to retinal neovascularization。 While significant progress has been m...

摘要：Pig-tailed macaques infected with human immunodeficiency virus (HIV) type 2GB122 or simian/HIV89。6p express virus in semen during primary infection: new model for genital tract shedding and transm...

摘要：Original citation: J。 Clin。 Invest。 115:2762-2773 (2005)。 doi:10。1172/JCI24381 Citation for this corrigendum: J。 Clin。 Invest。 1163292 (2006)。 doi:10。1172/JCI24381C1 The units “nmol“ an...

摘要：Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury。

摘要：1Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Medical College of Cornell University (WMCCU), New York, New York, USA。 3Divisions of Hematology/Medical Oncology, Medical a...