摘要:【摘要】 Nitric oxide (NO) modulates the biological levels of arachidonate-derived cell signaling molecules by either enhancing or suppressing the activity of prostaglandin H2 isoforms (PGHS-1...
08-05-29摘要:Hepatocyte growth factor/scatter factor (HGF/SF) is a high-molecular weight polypeptide growth factor initially discovered for its activity as a mitogen for liver cells10-12 and as a motility facto...
08-05-29摘要:Vascular endothelial growth factor (VEGF) plays a primary role in both pathological angiogenesis and abnormal vascular leakage in diabetic retinopathy。 EphrinA1 also inhibited VEGF-induced retinal...
08-05-29摘要:【摘要】 Chondrosarcoma is a malignant cartilage tumor that may arise from benign precursor lesions, such as enchondromas。 Some cases of multiple enchondromas are caused by a mutation that re...
08-05-29摘要:Ling Wang of the Burnham Institute Mouse Genetics Laboratory Shared Resource。 Roy-Burman through the National Cancer Institute Mouse Models of Human Cancer Consortium。 Davis Center for Comparativ...
08-05-29摘要:Cav-1 Deficiency Induces Defects in Cell-Substrate Attachment and Increased MMP Secretion with Loss of Collagen Type IVDuring the development of a hyperplastic lesion, mammary epithelial cells unde...
08-05-29摘要:Br J Haematol 2002, 119:122-124Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, Eto T: Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma。 Int Rev C...
08-05-29摘要:3 Matrix metalloproteinases (MMPs) are capable of digesting various components of the ECM and other molecules such as growth factors, cell surface receptors, and cell adhesion molecules and thus pl...
08-05-29摘要:【摘要】 Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase that plays an important role in oxidative stress-induced apoptosis。Apoptosis signal-re...
08-05-29摘要:【摘要】 Apolipoprotein E4 (ApoE4) is associated with Alzheimer。 We generated six transgenic mice strains expressing human ApoE4 in combination with mutant amyloid precursor protein (APP) and...
08-05-29摘要:Effects of STZ-Induced Diabetes on Body Weight and Blood Glucose Levels in Control and Diabetic, Diabetic Treated with CBD Animals, or Control Treated with CBDCBD Prevents BRB Breakdown in Experime...
08-05-29摘要:Pro-NGF/NGF Inhibits Proliferation and Promotes Apoptosis in Keratinocytes of Cultured Human Scalp Skin Hair FolliclesHair follicles cultured in the presence of 5 or 50 ng/ml of 7S NGF showed signi...
08-05-29摘要:Polycystic kidney disease is characterized by the enlargement of renal cysts, interstitial fibrosis, and gradual loss of normal renal tissue in association with progressive deterioration of renal f...
08-05-29摘要:In these studies, we sought to establish a relationship between these two pools of Aß。 We identified an inverse relationship between intracellular and extracellular Aß。17 In this curren...
08-05-29摘要:Germline transmission of the targeted allele to female agouti pups was confirmed by PCR (Figure 1E) 。 Abnormalities of the Sertoli cell cytoskeleton in AR113Q knock-in males。 Cell 1993, 73:1155-1...
08-05-29摘要:Virus antigen expression in these tissues was associated with severe necrosis and inflammation 7 days after inoculation。Materials and MethodsVirus PreparationA virus stock was prepared of influenz...
08-05-29摘要:Because TNF- is central to the pathogenesis of psoriasis and psoriatic epidermis has a low apoptotic index with high expression of Bcl-xL, we hypothesized that inflammatory Fas signaling mediates i...
08-05-29摘要:3 IL-27 mediates its functions by signaling through the IL-27R, which is composed of the T-cell cytokine receptor (TCCR/WSX-1) and the signal transducer gp130。7 However, the expression of WSX-1 is...
08-05-29摘要:【摘要】 Molecular typing of the abnormal form of the prion protein (PrPSc) has come to be regarded as a powerful tool in the investigation of the prion diseases。 All evidence thus far presen...
08-05-29摘要:20,21Isolation and Characterization of Human Invasive EVT PopulationsCultures of first trimester invasive trophoblast populations were established and characterized as previously described。Flow Cy...
08-05-29摘要:Because these changes resemble growth plate remodeling, we hypothesized that collagen degradation may be inhibitable by growth factors known to suppress growth plate hypertrophy, namely transformin...
08-05-29摘要:Statistical EvaluationThe level of significance was determined by standard statistical tests including Kruskal-Wallis (comparison between AA and controls) and the paired Student。ResultsEvaluation ...
08-05-29摘要:【摘要】 Polyamines are essential for normal cellular growth and function。 Polyamine depletion was associated with arginine- and cerulein-induced pancreatitis as well as with human acute necr...
08-05-29摘要:Rats were subjected to 1 hour per day of water avoidance stress or sham stress daily for 10 days, and horseradish peroxidase (HRP) was delivered by gavage on day 5。Materials and MethodsAnimal Trea...
08-05-29摘要:【摘要】 Bladder cancer is a common malignancy requiring a high degree of surveillance because of the frequent recurrences and the poor clinical outcome of invasive disease。------------------...
08-05-29摘要:The evolutionarily conserved Musashi family of RNA-binding proteins is associated with maintenance and/or asymmetric cell division of neural progenitor cells, and a mammalian Musashi protein is exp...
08-05-29摘要:9,10Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that act as key regulators of tissue remodeling11 and have been shown to participate in a number of ocular disease...
08-05-29摘要:【摘要】 Nicotinic acetylcholine receptors (nAChRs), present in human bronchial epithelial cells (HBECs), have been shown in vitro to modulate cell shape。 In vivo and in vitro, 35ß。 Wou...
08-05-29摘要:1-5 Podocytes are highly differentiated and specialized epithelial cells anchored to the glomerular basement membrane (GBM)。Estimation of Glomerular Volume and Number of Podocyte/GlomerulusEstimat...
08-05-29摘要:We investigated the role of the mitogen-activated protein kinase (MAPK) signaling pathway (ie, ERK1/2) and apoptosis-regulating Bcl-2 family members (ie, Bcl-xL and Bax) in the resolution of a rat ...
08-05-29摘要:Midkine expression was induced in the glomerular mesangium of Mdk+/+ mice with diabetic nephropathy and in primary cultured mesangial cells exposed to high glucose。5,6Midkine (MK) is a heparin-bin...
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