摘要：【摘要】 Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) regulates a variety of endothelial and immune cell biological responses。 PECAM-1-null mice exhibit prolonged and increase...

摘要：【摘要】 CD44, a cell-surface receptor for hyaluronan, has been implicated in endothelial cell functions, but its role in the formation of blood vessels in vivo has not been established。 In C...

摘要：Femoral Artery InjuryFemoral artery injury was performed at 6 months as described。Evaluation of Aortic Atherosclerosis and Femoral Artery Injury RepairTwo months after arterial injury, mice (n = 6...

摘要：【摘要】 We examined the role of phagocyte-derived oxygen radicals in tumor cell acquisition of metastatic phenotype by comparing gp91phoxC/C mice and C57BL/6J wild-type (WT) mice。 The gp91ph...

摘要：【摘要】 EphB4, a member of the largest family of receptor tyrosine kinases, is normally expressed on endothelial and neuronal cells。 Although aberrant expression of EphB4 has been reported i...

摘要：【摘要】 Dysregulated epidermal growth factor receptor (EGFR) signaling is involved in gastric cancer (GC) cell growth。 However, the mechanism that sustains EGFR signaling in GC remains unkno...

摘要：【摘要】 Disabled-2 (Dab2) is a phosphoprotein involved in cellular signal transduction and endocytic trafficking。-----------------------------------------------------------------------------...

摘要：Determination of HAS and Hyaluronidase ExpressionExpression of HAS isozymes 1, 2, and 3 was assayed by reverse transcriptase-polymerase chain reaction (RT-PCR) as previously described。 Expression ...

摘要：Expression of OPN Increases in Vivo Lymphovascular Invasion and Lymphatic Metastasis via Involvement of the RGD Integrin-Binding DomainTo compare in vivo tumorigenicity and spontaneous metastatic a...

摘要：Here, we show that the host response to a single JHMV-specific immunodominant CD4 T-cell epitope is critical for severe disease。 We engineered a recombinant JHMV with mutations in the immunodomina...

摘要：【摘要】 We have examined the development and transgene expression in liver lesions of transgenic mice bearing the hepatitis B surface antigen (HBsAg) gene of hepatitis B virus under the contr...

摘要：DC-SIGNR, a type 2 C-type lectin expressed on liver sinusoids, has been shown to bind with high affinity to hepatitis C virus (HCV) E2 glycoprotein。 DC-SIGN is a closely related homologue reported...

摘要：Lancet 1987, 1:893-895Renno T, Taupin V, Bourbonniere L, Verge G, Tran E, De Simone R, Krakowski M, Rodriguez M, Peterson A, Owens T: Interferon-gamma in progression to chronic demyelination and ne...

摘要：【摘要】 We hypothesized that proteinase-activated receptor-2 (PAR2) modulates intestinal injuries induced by ischemia/reperfusion。 Ischemia (1 hour) plus reperfusion (6 hours) significantly ...

摘要：1-3 Parietal cell stimulation results in insertion of tubulovesicular membranes harboring the H+/K+-ATPase pump in the apical plasma membrane。15 Parietal cells from Ae2a,bC/C mice showed labeling ...

摘要：Neuron 2002, 35:419-432Dennler S, Goumans M-J, Dijke PT: Transforming growth factor ß。 Transforming Growth Factor-ß。 1996:pp 275-308 Plenum Press, New YorkLuethviksson BR, Gunnlaugsdott...

摘要：Antithrombin is the most important endogenous anticoagulant。 Deficiency of this serpin significantly increases the risk of venous thrombosis, and homozygous deficiency is lethal。3 Antithrombin de...

摘要：17 Retinal development is morphologically normal, but progressive retinal degeneration is reported to be evident at 3 months after birth。 Cell Signaling Technology, Beverly, MA), caspase-3 (1:1000...

摘要：【摘要】 The pro form of neurotrophic growth factor (pro-NGF), purified by chromatography from human Alzheimer。3Recent studies have shown that in Alzheimer。Isolation of Pro-NGF from Human Br...

摘要：【摘要】 Large deletions in WNK1 are associated with inherited arterial hypertension。 WNK1 encodes two types of protein: a kidney-specific isoform (KS-WNK1) lacking kinase activity and a ubiq...

摘要：Th1 and Th2 cells both differentiate from common T precursor cells, with transcription factor GATA-3 a key regulator of Th2 differentiation。 In the present study, therefore, we examined the effect...

摘要：--------------------------------------------------------------------------------Acute respiratory distress syndrome (ARDS), first described in 1967 by Ashbaugh and colleagues,1 remains an important...

摘要：We found that skeletal muscle-derived cells in the constructs exhibited sustained electrical coupling through persistent expression and function of gap junction proteins。 Finally, using optical ma...

摘要：7,10,11Interleukin-13 (IL-13), a Th2 cytokine produced by multiple cell types, including T cells and natural killer cells, has been implicated in both inflammatory cell recruitment and remodeling i...

摘要：Bone morphogenetic protein (BMP)-4, a member of the TGF-ß。 J Clin Invest 2004, 114:1308-1316Zeisberg M, Shah AA, Kalluri R: Bone morphogenic protein-7 induces mesenchymal to epithelial transi...

摘要：Glomerular Isolation97% pure, allowing reliable assessment of glomerular-specific gene expression in mice。 Glomerular RNA from 7-week-old wild-type, 7-week-old Alport, and 4-week-old Alport mice w...

摘要：Protocol 1: Effect of SnPP on Renal Hemodynamics in Wild-Type and Sickle MiceTo examine the role of HO in maintaining renal hemodynamics in wild-type and sickle mice, SnPP (50 µ。 Renal vascul...

摘要：【摘要】 Although the roles of survivin in control of cancer cell division and apoptosis as well as targeting survivin for cancer therapeutics have been extensively explored and reviewed, the ...

摘要：We investigated the consequences of NaCl on pro-inflammatory chemokine and cytokine production by macrophages。 Stimulation of mouse macrophages with increasing amounts of NaCl induced macrophage i...