摘要：【摘要】 We previously reported that truncation of Notch1 (N1) by provirus insertion leads to overexpression of both the intracellular (N1IC) and the extracellular (N1EC) domains。------------...

摘要：1,2 Complement can be activated via the classic, alternative, or mannose-binding lectin (MBL) pathways, each of which converges on C3, the central hub of the complement system。16,17Complement C1q ...

摘要：【摘要】 Vascular aging is associated with dysregulation of tumor necrosis factor (TNF)- expression。 TNF- is a master regulator of vascular proatherogenic phenotypic changes, and it has been ...

摘要：【摘要】 Although chromosomal instability characterizes the majority of human colorectal cancers, the contribution of genes such as adenomatous polyposis coli (APC), KRAS, and p53 to this form...

摘要：ResultsSFKs Are Phosphorylated in NSCLCSFKs are recruited to the cytoplasmic membrane by receptor tyrosine kinases where they undergo activation through a series of phosphorylation and dephosphoryl...

摘要：Neurosurgery 2001, 49:857-862Beaulieu E, Kachra Z, Mousseau N, Delbecchi L, Hardy J, Beliveau R: Matrix metalloproteinases and their inhibitors in human pituitary tumors。 Neurosurgery 1999, 45:143...

摘要：【摘要】 Activation of the Hedgehog (Hh) pathway has been identified in several cancers, including medulloblastoma, but the mechanisms by which this pathway affects tumor survival and growth a...

摘要：Cell 1999, 98:769-778Jackson DG, Prevo R, Clasper S, Banerji S: LYVE-1, the lymphatic system and tumor lymphangiogenesis。 Microvasc Res 1999, 57:30-43Azzali G: Transendothelial transport and migra...

摘要：【摘要】 Here, we examine the role of “non-muscle“ caveolins (Cav-1 and Cav-2) in skeletal muscle biology。 Our results indicate that skeletal muscle fibers from male Cav-1(C/C) and Cav-2(C/...

摘要：20 Fibrillin-1 is the principal constituent of microfibrils, which in mature elastic fibers form a mantle around the elastic core or can be found as individual entities in nonelastic tissues。 Kidn...

摘要：Matrix Biol 1998, 17:269-278Hedbom E, Antonsson P, Hjerpe A, Aeschlimann D, Paulsson M, Rosa-Pimentel E, Sommarin Y, Wendel M, Oldberg A, Heinegard D: Cartilage matrix proteins。 J Biol Chem 2001, ...

摘要：Peptide SynthesisPLP139-151 (HSLGKWLGHPDKF), its mannosylated form (M-PLP139-151), and mannosylated OVA371-386 (M-OVA371-386) (HIATNAVLFFGRSVS)19,20 were synthesized as described elsewhere。Peptide...

摘要：Adrenomedullin also induced the generation and/or activation of efficient CD4+CD25+ regulatory T cells in arthritis with capacity to suppress autoreactive response and restore immune tolerance, whi...

摘要：We demonstrate that these T cells were imprinted with homing receptor patterns characteristic for the site of priming, such as 4ß。7 integrin for mucosal antigen delivery or functionally activ...

摘要：【摘要】 Relapsing fever is an infection characterized by peaks of spirochetemia attributable to antibody selection against variable serotypes。 We previously identified differences in spiroch...

摘要：We have previously reported that Fas/FasL interactions in epidermis are altered during cutaneous leishmaniasis (CL) and that keratinocyte death through apoptosis may play a pathogenic role for skin...

摘要：It has been suggested that Th1 responses promote disease, whereas Th2 responses are protective。 To address this question, bone destruction was evaluated in mice immunized to develop strong and pol...

摘要：Axonal degeneration was not obvious until 1 month after sensitization, and extensive axonal swelling was observed 2 months after sensitization (Figure 3, e and f) 。 Axonal degeneration in the spin...

摘要：3 Wound healing is accelerated in TNF-receptor-554 or IFN--deficient mice5 but is impaired in mice deficient for IL-66 or MCP-1。Wounding and Preparation of Wound TissueMice were anesthetized by in...

摘要：【摘要】 Prostate and mammary cancer bone metastases can be osteoblastic or osteolytic, but the mechanisms determining these features are unclear。 Bone morphogenetic and Wnt proteins are oste...

摘要：--------------------------------------------------------------------------------Hepatic stellate cells (HSCs), also known as Ito cells, lipocytes, or fat-storing cells, are nonparenchymal cells tha...

摘要：Bioinformatics ResourcesTranscription factor binding site analysis combined with a literature search was performed using MatInspector (Genomatix Software, Munich, Germany)。

摘要：Cells were then sonicated and centrifuged at 14,000 rpm for 15 minutes at 4。Flow Cytometry of Lung, Spleen, and BALF CellsIsolation of Lung and Spleen CellsLung mononuclear cells were isolated by ...

摘要：【摘要】 The transforming growth factor (TGF)-ß。-inducible integrin vß。6 is preferentially expressed at sites of epithelial remodeling and has been shown to bind and activate laten...

摘要：We investigated whether the metastasis suppressor KAI1 (CD82) is expressed at the maternal-fetal interface。 Immunohistochemistry showed strong expression of KAI1 in decidual cells, whereas trophob...

摘要：In this study, we show that heteromeric complexes composed of wild-type and mutant myocilin were retained in the rough endoplasmic reticulum, aggregating to form inclusion bodies typical of Russell...

摘要：Autophagy is the regulated process by which cytoplasmic constituents are targeted to lysosomes for degradation。8,20 Autophagy is elicited in several neurodegeneration models, contributing to degra...

摘要：--------------------------------------------------------------------------------Endothelial nitric-oxide synthase (eNOS) is implicated in numerous aspects of renal vascular control and function。 P...

摘要：【摘要】 Neutrophil elastase is a serine protease stored in the azurophilic granules of leukocytes。 Neutrophil burden of bleomycin-treated wild-type and neutrophil elastase-null mice was comp...

摘要：J Immunol 1998, 160:509-513Lehmann PV, Forsthuber T, Miller A, Sercarz EE: Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen。

摘要：Measurement of Complement Activation by Factors Released by ANCA-Stimulated Human NeutrophilsIgG from healthy controls (n = 8), MPO-ANCA patients (n = 6), or PR3-ANCA patients (n = 8) was prepared ...

摘要：The main objective of this study was to investigate whether Chlamydia pneumoniae (CP) infection occurred beyond the coronary plaques, namely in the myocardium of individuals who died of AMI。In sev...

摘要：Glycoconj J 1996, 13:797-807Wu R, Zhao YH, Chang MM: Growth and differentiation of conducting airway epithelial cells in culture。 Am J Physiol 2003, 285:L149-L160Takeyama K, Dabbagh K, Lee HM, Agu...

摘要：Vascularization Mechanisms in Cancer 【关键词】 alternative vascularization mechanisms Endothelial SproutingThe best-known mechanism by which tumors promote their own vascularization i...