摘要：【摘要】 Lymphangiogenesis is associated with human and murine cancer metastasis, suggesting that lymphatic vessels are important for tumor dissemination。 Lymphatic vessel alterations were ex...

摘要：Immunohistochemical studies demonstrated that ephrinB1 and EphB1 were expressed in basic fibroblast growth factor (bFGF)-induced vascularized corneas。 EphB1 was specifically colocalized with vascu...

摘要：This detailed characterization of the interaction of CRP with Fc receptors is a key step toward a molecular understanding of the physiological role of CRP and its potential role in cardiovascular d...

摘要：Proteins bound to this fusion protein were isolated by affinity chromatography on glutathione-Sepharose 4B and analyzed by Western blotting。ImmunoprecipitationProteins were immunoprecipitated from...

摘要：【摘要】 The homeobox gene CDX2 plays a major role in development, especially in the gut, and it also acts as a tumor suppressor in the adult colon。 Using orthotopic and heterotopic xenograft...

摘要：Transient TransfectionClaudin-7 expression was knocked down using Dharmacon SMARTpool RNAi claudin-7。ResultsClaudin-1, -4, and -7 Are Expressed in Esophageal SCC Cells but Not in Normal Esophageal...

摘要：【摘要】 Peroxisome proliferator-activated receptor (PPAR) is a metabolic regulator involved in maintaining glucose and fatty acid homeostasis。-----------------------------------------------...

摘要：12 Tumors secrete chemokines that direct bone marrow-derived monocytes (BDMCs) toward the tumor site and cytokines that prolong survival of these infiltrating cells。10,11,13 Tumor-associated macro...

摘要：17Measurements of Vitamin B12, Folate, and Hcy ConcentrationsPlasma and cerebral concentrations of vitamin B12 and folate were determined by radio-dilution isotope assay (simulTRAC-SNB。ResultsVita...

摘要：Relationship between cytokine signaling and amyloid-ß。 peptide (Aß。 Thus, we generated a novel Swedish ß。-amyloid precursor protein mutant (APP) transgenic mouse in which the inte...

摘要：ResultsPesticide Treatment of Presymptomatic M83 A53T -Syn Mice Exacerbates -Syn PathologyCohorts of 3-, 8-, and 12-month-old NTg, M7 Tg, and nonsymptomatic M83 Tg mice were exposed to saline, PQ, ...

摘要：Rapsyn overexpression resulted in an increase in total muscle membrane AChR levels, with some AChR at neuromuscular junctions but much of it in extrasynaptic membrane regions。5 Rapsyn links the AC...

摘要：35 Protein concentrations were determined by the BCA protein assay (Pierce, Rockford, IL)。Total Protein Extract and Western BlottingMuscles (0。 Protein homogenates (40 mg) recovered from the obta...

摘要：ResultsDetection of Brown Adipocytes during BMP2-Induced Bone FormationFour mice per experimental group were euthanized each day for 7 days, their tissues fixed in 10% neutral buffered formalin, an...

摘要：【摘要】 Transgenic expression of the 7ß。 To explore the possibility that elevating 7ß。 Unlike 7 transgenic mdx/utrC/C mice, enhanced 7ß。1 This complex consists of dystrophin...

摘要：Mitochondrial Oxidative Enzyme Expression Decreases in Fast-Twitch, Glycolytic Muscles in CSQ MiceTo characterize the skeletal muscle abnormalities with regard to the expression of contractile prot...

摘要：--------------------------------------------------------------------------------Leptin, a small peptide molecule produced from the obese (ob) gene product and synthesized and secreted mainly by adi...

摘要：Elastic fiber synthesis and assembly is a complex process that is incompletely understood。20Quantification of DesmosineElastic fiber content was assessed by radioimmunoassay for desmosine, an amin...

摘要：In this study, we document that the interactions between fibronectin, a key extracellular matrix protein, and its integrin receptor 4ß。 The presence of the active form of MMP-9 was accompanie...

摘要：Viral titers were determined by plaque assay on DBT cells。Induction of CNS Immune PathologyIsoflurane-anesthetized mice were inoculated with 30 µ。ResultsMHV-Induced Acute CNS Disease Is Exac...

摘要：11 Galectin-1, -3, and -9 are expressed in thymus, among which galectin-1 and -3 are present throughout all of the thymic parenchyma, being mainly produced by thymic epithelial cells (TECs)。 Galec...

摘要：【摘要】 Severe acute respiratory syndrome (SARS) is a novel infectious disease with disastrous clinical consequences, in which the lungs are the major target organs。 【关键词】 mol...

摘要：【摘要】 The widespread distribution of Toll-like receptors (TLRs) and their ligands raises the question whether they contribute to the production of inflammatory and tissue destructive molecu...

摘要：【摘要】 Neutrophilia is a characteristic of hemolytic uremic syndrome caused by Shiga toxin (Stx2)-producing Escherichia coli。 coli infection remains undefined。 coli Stx2 and lipopolysaccha...

摘要：Functional Capillary DensityFCD is the total length of RBC-perfused capillaries divided by the area of microscopic field of view。18 Functional capillaries are defined as those capillary segments t...

摘要：Nat Immunol 2001, 2:907-916Kawachi S, Cockrell A, Laroux FS, Gray L, Granger DN, van der Heyde HC, Grisham MB: Role of inducible nitric oxide synthase in the regulation of VCAM-1 expression in gut ...

摘要：Rgmc Repression by LPS Is Independent of HfeNext, to assess whether changes in Rgmc mRNA expression are appropriately elicited in Hfe-deficient mice, we measured Rgmc mRNA expression in HfeC/C and ...

摘要：Transfected and infected hepatocytes expressed HCV core protein and HCV negative-strand RNA。 Transfected and naï。RNA Extraction and Quantification of HCV RNAHCV RNA was isolated from culture ...

摘要：Hypoxia inducible factor-1 (HIF-1) is a heterodimeric (/ß。 Hypoxia-induced HIF-1 expression was further enhanced when insulin was added to culture medium (Figure 2, A and D) 。 Pancreas 2000,...

摘要：Interstitial fibrosis was quantified as the area involved in interstitial fibrosis (grade 1: 1/3 but 2/3)。 directives and samples processed according to the protocol of the European Renal cDNA Ba...

摘要：13Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis worldwide, and a significant proportion (20 to 30%) of patients progress to renal failure 10 to 20 years after the onset ...

摘要：14LPS-Induced Endotoxic ShockLPS (from Escherichia coli 0111:B4。ResultsMLCK210 C/C Mice Are Protected Against Endotoxic ShockWe assessed the effect of LPS injection and CLP on survival of mice。De...

摘要：Regardless of cause, osteoporosis reflects a relative enhancement of osteoclast activity。 Thus, this unique bone resorptive cell is a prominent therapeutic target。 A number of key observations pr...