摘要：Vimentin is an intermediate filament characteristic of leukocytes, endothelial cells, and proliferating smooth muscle cells。Recombinant Murine VimentinThe cDNA for mouse vimentin was isolated from...

摘要：16Hydrogen sulfide (H2S) has long been known as a toxic gas but has only recently been regarded as a novel gasotransmitter, possessing very important physiological and pharmacological functions in ...

摘要：Soluble fms-like tyrosine kinase-1 (sFlt-1) seems to interfere with these events by inhibiting local angiogenesis and/or by impeding trophoblast invasion。16,39 Thrombin-induced decidual sFlt-1 exp...

摘要：【摘要】 Ischemia/reperfusion (I/R) is often inevitable during hepatic surgery and may stimulate the outgrowth of colorectal micrometastases。ResultsMicrocirculatory Failure after I/R Is Assoc...

摘要：Hypoxia (1% O2) altered the location of claudin-5 in the plasma membrane and the level of claudin-5 protein in bEND。25 Hypoxia stimulates the cellular production of erythropoietin,26 vascular endo...

摘要：Microvessel Density CountingMicrovessel densities were evaluated by counting the number of CD34+ microvessels in the entire 1。 Microvessel density was scored by counting and encoded by setting the...

摘要：Here, we report that the oncogene Bmi-1 is highly expressed in human neuroblastoma cell lines and primary tumors。 Neuroblastoma development in MYCN transgenic mice, an animal model for the human d...

摘要：Reduced Size and Impaired Vascularization in Rip1VEGF-D IsletsBesides binding to VEGFR-3 and inducing lymphangiogenesis, the fully processed form of human VEGF-D (VEGF-DNC) has been repeatedly show...

摘要：Aggrus/podoplanin is a platelet aggregation-inducing factor that is up-regulated in a number of human cancers and has been implicated in tumor progression。 We studied herein the role of Aggrus in ...

摘要：12,13When studying the molecular mechanisms of toxicity, both the PrP106-126 peptide and scrapie-infected extracts were found to have no effect on neurons from prion protein knockout mice (PrP0/0),...

摘要：Cyclooxygenase inhibitors also reduced the tumor phenotype in a preliminary study。Cyclooxygenase (Cox)-2, encoded by the prostaglandin synthase 2 (ptgs2) gene, is a key downstream component of gon...

摘要：【摘要】 Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease of the central nervous system resulting from the productive infection of oligodendrocytes by the oppo...

摘要：Mutant neuroserpin polymerizes and forms intracellular aggregates that eventually lead to neurodegeneration。 【关键词】 accumulation neuroserpin precedes development clinical symptoms fa...

摘要：Glutamate significantly inhibited osteoclastogenesis at a concentration over 500 µ。 These results suggest that glutamate may play a pivotal role in mechanisms associated with osteoclastogenes...

摘要：28 Interstitial cell counts were determined in 15 high-power fields (x400) by a blinded observer。ResultsUninephrectomy Accelerates Diabetic Nephropathy and Renal Ccr1 mRNA Expression in db/db Mice...

摘要：【摘要】 Decay-accelerating factor (DAF) is a glycosylphosphatidylinositol-anchored membrane protein that restricts complement activation on autologous cells。 Previous studies have establishe...

摘要：【摘要】 We show that inhibitory effect of interleukin-13 on endotoxin-induced uveitis in the Lewis rat is dependent on signaling activity of protein kinase C (PKC)。 To understand the effect ...

摘要：Because CC chemokine receptor 6 (CCR6) deficiency affects the generation of mucosal immune responses, we evaluated a potential role for CCR6 in the development of ILFs。 We observed that CCR6 and i...

摘要：ResultsGastric Ulceration Triggers Local Activation of IGF-1 in the Ulcer MarginsTo measure IGF-1 concentration in control and ulcerated gastric tissues, we performed enzyme-linked immunosorbent as...

摘要：Western Blot AnalysisProtein aliquots were used to determine protein concentration (Bio-Rad DC Protein Assay。 Effects of E2-BSA and E2 on Plasma -Glutathione S-Transferase (-GST) Levels after Sham...

摘要：peptide production and cleave Tau and several synaptic proteins (LeBlanc AC, Liu H, Goodyer C, Bergeron C, Hammond J: Caspase-6 role in apoptosis of human neurons, amyloidogenesis and Alzheimer。Ta...

摘要：【摘要】 Statins induce heme oxygenase-1 (HO-1) in several cell types, such as vascular smooth muscle cells, endothelial cells, and macrophages。2 Statins activate the HO-1 promoter in endothe...

摘要：Collection and Culture of Peritoneal MacrophagesThioglycollate-induced macrophages were collected from the peritoneal cavity (peritoneal exudate cells。Collection of F4/80- and CD11b-Positive Macro...

摘要：Treatment with the lipophilic simvastatin was not renoprotective。Rosuvastatin but Not Simvastatin Reduces Proteinuria in SHRSPsAfter 6 weeks of salt loading, there was a progressive increase in ur...

摘要：【摘要】 Idiopathic interstitial pneumonias (IIPs) are a collection of pulmonary fibrotic diseases of unknown etiopathogenesis。 CC chemokine receptor 7 (CCR7) is expressed in IIP biopsies and...

摘要：【摘要】 Severe acute respiratory syndrome (SARS) is an emerging infectious viral disease characterized by severe clinical manifestations of the lower respiratory tract。----------------------...