摘要：Purification of Glycosaminoglycans (GAGs)/Proteoglycans of Human PlacentaAll GAG/proteoglycan isolation was performed on ice-bath or in cold room at 4。33Compositional Analysis of Placental GAGs/Pr...

摘要：Placental hypoxia is often invoked as an underlying cause or contributor to the development of preeclampsia and/or fetal growth restriction。17 Placental tissues were fixed in buffered formalin and...

摘要：【摘要】 Pigment epithelium-derived factor (PEDF) inhibits cytokine-induced endothelial cell activation through its antioxidative properties。 However, the effect of PEDF on restenosis remains...

摘要：Cell Signaling Technology, Beverly, MA) together with a rat polyclonal antibody against F4/80 (1:100。 Cell Signaling Technology), or an anti--tubulin antibody (1:2000。Suppression of STAT3, but No...

摘要：Functional Role of LM-511 in Breast Cancer CellsThe results above are strongly suggestive of a functional role of LM-511 in the metastasis of breast tumors。 Matrix Biol 2006, 25:189-197Givant-Horw...

摘要：10 Homozygous Mutant MiceA neomycin cassette (called KT3NP4) was inserted into a unique BssHII restriction site located within the 5‘ untranslated region of somatic ACE。Macrophage ExpansionFor la...

摘要：【摘要】 The expression of WAVE3, an actin-cytoskeleton and reorganization protein, is elevated in malignant human breast cancer, yet the role of WAVE3 in promoting tumor progression remains u...

摘要：【摘要】 Membrane type 1-matrix metalloproteinase (MT1-MMP) is a major mediator of collagen I degradation。6Membrane type 1-matrix metalloproteinase (MT1-MMP) is a membrane-anchored protease t...

摘要：【摘要】 In this study, we examined ErbB1 signaling in human basal and squamous cell carcinomas (BCC and SCC) of the skin in vivo。 We used enzyme-linked immunosorbent assay, laser capture mic...

摘要：Vacuolar degeneration in white tracts was attributable to myelin unwinding and intramyelinic cysts, and double-label immunofluorescence for 4-hydroxy-2-nonenal and myelin basic protein localized fr...

摘要：【摘要】 Acid sphingomyelinase knockout mice are a model of the inherited human disorder types A and B Niemann-Pick disease。 Sperm sorting is much less invasive and more cost-effective than e...

摘要：Biochim Biophys Acta 2004, 1692:77-102Mitra SK, Hanson DA, Schlaepfer DD: Focal adhesion kinase: in command and control of cell motility。 Cancer Res 2001, 61:8385-8389McLean GW, Avizienyte E, Fram...

摘要：【摘要】 Aminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1。Affinity Purification of AIMP1-Binding ProteinsRecombinant AIMP1 protein and bovine serum albumin (BSA) were bi...

摘要：Mice bearing a mutation in the Apc gene (Min) have been used to discover a modifier of Min (Mom1 or Pla2g2a) that affects tumor multiplicity and size of intestinal tumors。 【关键词】 ide...

摘要：【摘要】 Platelets have been shown to be important in inflammation, but their role in chronic allergic dermatitis remains unclear。1-8 Platelets accumulate in inflammatory sites concomitantly ...

摘要：【摘要】 p150/95 (CD11c/CD18, CR4) is a member of the ß。 To determine p150/95-mediated mechanisms in experimental autoimmune encephalomyelitis (EAE), we performed EAE using CD11c-deficie...

摘要：Construction and Expression of Recombinant Fusion Proteins Corresponding to NC1 SubdomainsThe fragment corresponding to the 700-bp CMP subdomain of human type VII collagen cDNA was generated by rev...

摘要：Here we demonstrate that severe hepatitis in CCR5-deficient (KO) mice is associated with increased hepatic NK cell recruitment driven by enhanced hepatic production of CCL5 acting via CCR1 and by e...

摘要：【摘要】 Keratinocyte growth factor (KGF) and KGF receptor (KGFR) have been implicated in cancer growth as well as tissue development and repair。5,6Keratinocyte growth factor (KGF) is a membe...

摘要：【摘要】 Pathological angiogenesis is associated with the fibrogenic progression of chronic liver diseases。 Experimental data suggest that hypoxia and vascular endothelial growth factor (VEGF...

摘要：ResultsDPO Attenuates Intrahepatic Inflammation and Systemic Cytokine Concentrations after Gal-LPS ChallengeAnalysis of hepatic microcirculation by fluorescence microscopy is given in Figure 1 。 C...

摘要：ResultsGeneration of WT, Leptin-Deficient, and Leptin Receptor-Deficient Preadipocyte Cell LinesCommercial availability of murine preadipocyte cell lines is limited to 3T3L1 cells。Leptin-Dependent...

摘要：ApoptosisApoptotic cells were determined by the propidium iodide method。Up-Regulation of Caspase-8 by IFN-Because IFN- has been shown to up-regulate caspase-8 expression in vitro in various cell l...

摘要：Apoptosis occurs during tissue morphogenesis and homeostasis as an essential balance to cell replication and has been identified as part of normal placental development。12,13 Increased apoptosis h...

摘要：--------------------------------------------------------------------------------Skin mast cells (MCs) are known to contribute to the pathology of various skin disorders including allergic and autoi...

摘要：1,5Oxidants in vivo are multiple, heterogeneous, and include nonenzymatic reaction derivatives of free amine-containing nucleic acids, peptides, or lipids with ambient reducing sugars, termed advan...

摘要：【关键词】 contains vascular progenitor inducing vasculogenesis angiogenesis myogenesis peripheral ischemia Materials and MethodsHuman Fetal TissuesSamples of 11- to 12-week-old hFA, were obtain...

摘要：9,10 Proteoglycans are glycoconjugates consisting of extended linear carbohydrate side chains (glycosaminoglycans。 J Immunol Methods 2005, 298:155-159Rossi M, Morita H, Sormunen R, Airenne S, Krei...

摘要：In this study, we found that SRY-related HMG box 9 (SOX9) was bound to the GAACAAT motif in the Col4a2 enhancer in vitro and in vivo in mesangial cells。Recently, a family of transcription factors,...

摘要：【摘要】 Although angiotensin II (Ang II) type 1 receptor antagonist ameliorates proteinuria, its pharmacological mechanism and the differential roles of Ang II type 1 receptor (AT1R) and type...

摘要：【摘要】 MicroRNAs (miRNAs) are a recently discovered class of endogenous, small, noncoding RNAs that regulate gene expression。----------------------------------------------------------------...

摘要：Renal Hemodynamic Studies in MiceThese studies were performed as described in detail in our previous investigations。 Renal blood flow (RBF) was determined by an electromagnetic flow probe and a sm...

摘要：One cell, multiple origins。 J Cell Biol 2006, 172:259-268Wang J, Zohar R, McCulloch CA: Multiple roles of -smooth muscle actin in mechanotransduction。 Gastroenterology 2004, 126:955-963Direkze NC...