摘要：Anti-phospho STAT-3 antibodies (9145), anti-phospho STAT-5 antibodies (9351), anti-PY20 antibodies (9411), and anti-phospho pRb antibodies (9307) were supplied by Cell Signaling Technology (Beverly...

摘要：Antibodies against ERK1/2 and phosphorylated ERK 1/2 (Thr202/Tyr204) were from Cell Signaling Technology (Beverly, MA)。Endothelial Cell Proliferation and Growth Factor SignalingWild-type and Cd39-...

摘要：【摘要】 An adequate balance between serine proteases and their plasminogen activator inhibitor-1 (PAI-1) is critical for pathological angiogenesis。 PAI-1 deficiency in mice is associated wit...

摘要：Gene Expression AnalysesTotal RNA was extracted using the RNA-Bee reagent (Tel-Test, Inc。Tumorigenic AssaysThree- to 4-week-old athymic nude (nu/nu) NCr mice (Taconic Farms, Germantown, NY) were u...

摘要：T+E2 Co-Treatment Selectively Induced Inflammation and Premalignant Dysplasia in the LPs, but Not in the VPs, of Treated RatsThe T+E2-induced histopathological changes in the NBL rat model have bee...

摘要：【摘要】 Chondroitin sulfate (CS) is abundantly present in the tumor stroma, and tumor-specific CS modifications might be potential targets to influence tumor development。 Antibody GD3G7 was ...

摘要：NRSF Transfection Down-Regulates SNAP25, Synaptophysin, UCHL1, and -Internexin Genes in DMS53 CellsAs mentioned above, some of the up-regulated neuronal proteins detected in myotilinopathy have bee...

摘要：Spine formation was unchanged, resulting in spine loss。 Spines that were followed for 1 hour (n = 962) were also assigned a classification of stable, formed, or eliminated。StatisticsSpine density...

摘要：Role of Plasminogen on tPA-Mediated Cerebral Ischemia-Induced NF-B Pathway ActivationTo determine whether the effect of tPA on NF-B is mediated by activation of plasminogen, WT and PlgC/C mice unde...

摘要：15 Expression profiles of 8400 genes in mouse skeletal muscle and spinal cord expressing SMN7 RNA only revealed an early, and specific, up-regulation of genes involved in pre-mRNA splicing, ribosom...

摘要：【摘要】 Experimentally evoked seizures can activate the intrinsic mitochondrial cell death pathway, components of which are modulated in the hippocampus of patients with temporal lobe epileps...

摘要：Chemotaxis Assay and FITC-Induced Cutaneous DC MigrationCells were tested for transmigration across uncoated 5-µ。

摘要：【摘要】 Viral attachment to the host cell is critical for tissue and species specificity of virus infections。 Recently, pattern of viral attachment (PVA) in human respiratory tract was deter...

摘要：Although, we previously established a good correlation between SjS in humans and autoimmune exocrinopathy in NOD/LtJ mice an in-depth evaluation of lacrimal gland disease in the NOD/LtJ mouse has r...

摘要：【摘要】 Minocycline exerts beneficial immune modulatory effects in several noninfectious neurodegenerative disease models。 Minocycline was also capable of protecting the brain parenchyma fro...

摘要：The c-Jun proteins that are early transcription factor molecules have been shown to regulate stromal-epithelial interactions via paracrine signals。 In this study, we show that c-Jun protein in fib...

摘要：Oxidative stress, activation of the nuclear factor-B pathway, tumor necrosis factor- and interleukin 1ß。 Generation of oxidative stress is associated with activation of the p38 and SAPK MAPK,...

摘要：【摘要】 Administration of recombinant human insulin-like growth factor-I (rhIGF-I) has beneficial effects in animal models of muscle injury and muscular dystrophy。 However, the results of th...

摘要：【摘要】 Chemotherapy-induced alopecia represents one of the major unresolved problems of clinical oncology。--------------------------------------------------------------------------------Che...

摘要：Blood from donors was carefully layered on Ficoll solution (density 1。Culture of PBMCs and Circulating Precursor Cells and Stimulation of Epithelial-Like Cell TransdifferentiationAfter the isolati...

摘要：Pulmonary Endothelial Cell CultureAdult lung microvascular endothelial cells were isolated and cultured as previously described。Quantification of Apoptotic Endothelial Cells by FACS AnalysisFor FA...

摘要：【摘要】 Integrin-mediated cell adhesion and signaling is essential to vascular development and inflammatory processes。 Integrin vß。 Integrin antagonist reduced the histological signs o...

摘要：--------------------------------------------------------------------------------Secreted protein acidic and rich in cysteine (SPARC), also known as BM-40 and osteonectin, is a 32-kd matricellular g...

摘要：【摘要】 Macrophage colony-stimulating factor (M-CSF), known as a hematopoietic growth factor, induces vascular endothelial growth factor (VEGF) production from skeletal muscles。 However, the...

摘要：The broad umbrella of gene-silencing therapeutics encompasses a range of agents that include DNA enzymes, short interfering RNA, antisense oligonucleotides, decoys, ribozymes, and aptamers。 This r...