摘要：The cardiovascular medicine community lost a leading light with the death, in April 2004, of Gardner C。 McMillan。 He recognized, early on, the complexity of human and experimental atherosclerosis...

摘要：From the Departments of Cell Biology, Cardiovascular Medicine, and the Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic Foundation, Cleveland, Ohio 44195Inflammation and the V...

摘要：Absence of p53 Leads to Accelerated Neointimal Hyperplasia After Vascular Injury。 Neointimal hyperplasia rapidly reaches steady state in a novel murine vein graft model。

摘要：eduABSTRACTIntracellular cholesterol transport is essential for the maintenance of cholesterol homeostasis。 Many aspects of cholesterol metabolism are well-known, including its synthesis in the en...

摘要：ABSTRACTVascular calcification, long thought to result from passive degeneration, involves a complex, regulated process of biomineralization resembling osteogenesis。 Evidence indicates that protei...

摘要：97Comparison of Baseline Characteristics Between Nurses’ Health Study and WHIHowever, the early increment in coronary event rates in the recent randomized controlled trials might have been precipi...

摘要：Neointimal thickening was greater at the proximal and, to a lesser extent, distal ends, in comparison to the middle of the graft。 Neointimal proliferation appeared early and adjacent to the graft-...

摘要：ABSTRACTObjective— Cyclophilin A (CyPA) is an abundant intracellular protein that is considered to be the main target of the immunosuppressive drug cyclosporine A。 Cyclophilin A is a secreted gro...

摘要：Comparative Regulatory Sequence Analysis of Coclustering GenesWe hypothesized that genes showing a common regulatory behavior may also share common regulatory mechanisms such as TFBSs in their resp...

摘要：ABSTRACTObjective— Several proinflammatory cytokines including IL-6 and IL-8 are produced by human adipocytes, but it is still unclear how this process is regulated。 Angiotensin (Ang) II, which i...

摘要：ResultsDetection of R-Cadherin and N-Cadherin by Western BlottingWestern blotting detected only 1 band of 120 and 130 kDa for R-cadherin and N-cadherin, respectively, (Figure 1)。Effect of Balloon ...

摘要：), University of Rochester, Rochester, NYABSTRACTObjective— CCL11 (Eotaxin) is a potent eosinophil chemoattractant that is abundant in atheromatous plaques。 The major receptor for CCL11 is CCR3, ...

摘要：ABSTRACTObjective— Microtubules are important in signal transduction temporal–spatial organization。 Full expression of angiotensin II (Ang II) signaling in vascular smooth muscle cells (VSMCs) i...

摘要：Basic fibroblast growth factor (bFGF) acts as a vasodilatator and angiogenic factor。 Basic fibroblast growth factor (bFGF), which is released from endothelial cells and macrophages during hypoxia ...

摘要：ABSTRACTObjective— Allograft inflammatory factor-1 (AIF-1) is associated with vascular smooth muscle cell (VSMC) activation and vascular injury。 The purpose of this study was to characterize the ...

摘要：ABSTRACTObjective— Electrical stimulation induces significant angiogenesis in vivo。 This intriguing directional selectivity indicates that a DC electrical signal as a directional cue may be able ...

摘要：Methods and Results— Fibroblasts were isolated from skin biopsies。Fibroblasts from type 2 diabetic subjects exhibit a higher level of P2X7 receptor activity compared with fibroblasts from healthy...

摘要：Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease。 Impaired recruitment of bone-marrow-derived endothelial...

摘要：Methods and Results— Coronary arteries from respective wild-type, M2–/–, or M3–/– mice were isolated, cannulated, and pressurized。ResultsResponses of Coronary Arteries from M2–/– and M3–/–...

摘要：Tocopherol-mediated peroxidation of lipoproteins: implications for vitamin E as a potential antiatherogenic supplement。

摘要：COX-2 and type 1 inducible PGE synthase (mPGES-1) have a role in metalloproteinase (MMP) release leading to plaque rupture。 In contrast, lipocalin-type PGD synthase (L-PGDS) has been shown to exer...

摘要：ABSTRACTObjective— Coronary atherosclerotic plaque composition of diabetic subjects and localization of receptor for advanced glycation end products (RAGE) and its ligands have not been extensivel...

摘要：Conclusions— Progression of CAC was significantly greater in patients receiving statins who had an MI compared with event-free subjects despite similar LDL control。 Calcium scoring was performed ...

摘要：ABSTRACTObjective— To assess the relationship between infrarenal aortic diameter and subsequent all-cause mortality in men aged 65 years or older。Methods and Results— Aortic diameter was measure...

摘要：Plaque cells replicated slightly faster than medial cells, with a population doubling time of 5 versus 7。 Smooth muscle cell heterogeneity: role of specific smooth muscle cell subpopulations in pu...

摘要：The University of Western Ontario Health Science Standing Committee on Human Research approved the studies。21,22Cell CultureExperiments were performed with 2 distinct human SMC clones, the epithel...

摘要：transgenic miceIntroductionApolipoproteins constitute a class of polypeptides found on plasma lipoprotein particles that play an important role in lipid transport and metabolism。Gene Expression An...

摘要：Conclusion— Pravastatin treatment, resulting in decreased LDL oxidation, did not improve myocardial perfusion reserve in subjects with type 1 diabetes。 Pravastatin decreased LDL oxidation。10Prav...

摘要：Macrophages at erosive sites of human coronary atheroma present myeloperoxidase (MPO), an enzyme that produces hypochlorous acid (HOCl)。 Macrophages at sites of ulceration in human atheromata can ...

摘要：From the Departments of Plasma Proteins (M。 Recently, we have shown that the small GTP-binding protein Ral is involved in thrombin-induced exocytosis of WPBs。 In the present study, we investigate...

摘要：ABSTRACTObjective— Protein C (PC) is a component of the protein C anticoagulant pathway。 quantitative trait locusIntroductionProtein C (PC) is a vitamin K-dependent protein that, after activation...

摘要：551), National Institute for Health and Medical Research (INSERM), Paris, FranceRoland StockerCentre for Vascular Research, University of New South Wales, Department of Haematology, Prince of Wales...