摘要：Smooth muscle cells (SMCs) have evolved to subserve a variety of diverse functions in higher vertebrates, including modulation of arterial tone, regulation of airway resistance, and control of gast...

摘要：From the Division of Cardiovascular Medicine, Department of Medicine (S。F。, M。F。L。), and the Departments of Pathology (S。F。) and Pharmacology (M。F。L。), Vanderbilt University Medical Cente...

摘要：1 Most risk factors that are related to atherosclerosis and cardiovascular morbidity and mortality, including hypercholesterolemia, hypertension, cigarette smoking, and diabetes mellitus, are found...

摘要：CohenATVB in FocusDiabetic Vascular Disease: Pathophysiological Mechanisms in the DiabeticMilieu and Therapeutic ImplicationsPrevious Brief Review in this Series:。43–45The Cyclooxygenase Pathway ...

摘要：From the Departments of Chemistry and Chemical Biology (E。), Department of Biology, Rensselaer Polytechnic Institute, Troy, NY。Examples of Heparin-Binding Vascular/Plasma ProteinsHeparin is a lin...

摘要：The Formation of a Fibrin ClotFibrin is the major protein constituent of the blood clot and is formed from fibrinogen, a glycoprotein that circulates largely inactively, in the blood stream。 Fibri...

摘要：the Human Genetics Center (E。3 Carotid IMT can be measured noninvasively in population-based samples free of many of the biases of clinically identified cases and controls。6Ultrasonographic measu...

摘要：ABSTRACTLaminopathies are genetic diseases that encompass a wide spectrum of phenotypes with diverse tissue pathologies and result mainly from mutations in the LMNA gene encoding nuclear lamin A/C。...

摘要：ABSTRACTObjective— Myocardin, a coactivator of serum response factor, has been shown to be required for expression of multiple CArG-dependent smooth muscle cell (SMC) marker genes。ResultsExpressi...

摘要：ABSTRACTIncreased understanding of the mechanisms of angiogenesis and lymphangiogenesis has provided a glimpse at some of the molecules involved in the pathophysiology of hemangiomas and vascular m...

摘要：ABSTRACTObjective— Hex (hematopoietically expressed homeobox), a member of homeobox family of transcription factors, has been implicated in the vascular development because of its expression in he...

摘要：ABSTRACTObjectives— The function of B-Myb, a negative regulator of vascular smooth muscle cell (SMC) matrix gene transcription, was analyzed in the vasculature。 Total B-Myb levels were elevated i...

摘要：Methods and Results— We compared endothelial function, vascular superoxide production, and the expression of NAD(P)H oxidase subunits in arteries and veins from patients undergoing coronary bypass...

摘要：MethodsPreparation of Fatty AcidsEPA, DHA, and arachidonic acid were purchased from Cayman Chemicals。 Oxidized and unoxidized EPA had no effect on the viability of these cells as determined by tet...

摘要：Estrogen pretreatment decreased lactate dehydrogenase release with hypoxia。 Estrogen decreased LDH release with hypoxia。 Estrogen-induced changes in blood lipid profiles can only account for 30% ...

摘要：12 Lysophosphatidylcholine (LysoPC) is present at high concentrations in oxidized LDL (oxLDL) and formed via the reaction of phospholipase A2。Contribution of SLC3A2 and SLC7A5 Expression to Cytoki...

摘要：ABSTRACTObjective— The aim of this study was to investigate the effect of various C-type natriuretic peptide (CNP) sequences (genomic DNA , cDNA derived from mRNA , and sequence coding for 22 amin...

摘要：ABSTRACTObjective— Migration of vascular smooth muscle cells (VSMCs) contributes to formation of vascular stenotic lesions such as atherosclerosis and restenosis after angioplasty。 Previous studi...

摘要：intimal thickeningIntroductionCigarette smoking is an important risk factor for stroke,1–3 mediated in part by accelerated intimal thickening and plaque development。Exposure to CS was performed i...

摘要：Correlation of plasma NOx and urinary IsoP levels with the severity of PVH and lacunar infarction。 Periventricular lesions in the white matter on magnetic resonance imaging in the elderly。

摘要：Fluid shear stress is the primary and strongest arteriogenic stimulus。 Shear stress regulation of artery lumen diameter in experimental atherogenesis。 Fluid shear stress and the vascular endothel...

摘要：Efflux-recapture model of LRP-mediated selective uptake。

摘要：ResultsMKP-1 Protein Is Expressed in Atherosclerotic Lesions of ApoE (–/–) MiceMKP-1 is an inducible immediate early gene, which is either absent or expressed at very low levels in most tissues u...

摘要：ABSTRACTObjective— Asymmetric dimethylarginine (ADMA) is widely believed to be an endogenous nitric oxide synthase (eNOS) inhibitor。14Asymmetric dimethylarginine (ADMA) is a naturally occurring L...

摘要：Because two ACAT isozymes (ACAT-1 and ACAT-2) were identified, in the present study we determined which ACAT isozyme was involved in the elevated intestinal ACAT activity in diabetic rats。Methods ...

摘要：Effects on lipoprotein subclasses of combined expression of human hepatic lipase and human apo-B in transgenic rabbits。

摘要：), Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Mass。 The experimental protocol was approved by the Human Investigation ...

摘要：The lamin A/C (LMNA) gene, mutations of which cause rare syndromes of severe insulin resistance and dyslipidemia, is located on chromosome 1q21-q24, a region linked to T2DM in several genome wide s...

摘要：Serial in vivo MRI of mouse arterial plaque after correction of dyslipidemia revealed a monotonic decrease in lesion size (regression) and changes in lesion composition consistent with a stable pla...

摘要：Diabetes was induced by streptozotocin injection in WT or endothelial-targeted guanosine 5‘-triphosphate cyclohydrolase I (GCH)-transgenic (GCH-Tg) mice protected from endothelial dysfunction in d...

摘要：Methods and Results— Blockade of glycoprotein (GP) VI by 9O12 antibody or of P2Y purinergic receptors permitted platelet adhesion but reduced aggregate formation, fibrinogen binding, and activatio...

摘要：Fish oil intake reduced plasma triglycerides and lowered platelet integrin activation, as well as plasma levels of fibrinogen and factor V, but had no effect on vitamin K-dependent coagulation fact...

摘要：Achille CittadiniInstitute of General Pathology, “Giovanni XXIII“ Cancer Research Center, Catholic University, Rome, ItalyTo the Editor:We read with great interest the article by Wagner et al, in...

摘要：1 This group has claimed in the past and intimated in this article that such doses are too low to affect bacteria and hence will not disturb the indigenous microbial flora or induce or select micro...