摘要：Tissue replacement in the adult organism by cell-specific differentiation of autologous stem/progenitor cells has evolved as a fascinating concept in stem cell biology。 After organ damage, bone ma...

摘要：ABSTRACTAspirin and the thienopyridines ticlopidine and clopidogrel are antiplatelet agents that display good antithrombotic activity。 In the past few years, the concept of aspirin resistance has ...

摘要：It is not surprising, therefore, that the platelet activation cascade (including receptor-mediated tethering to the endothelium, rolling, firm adhesion, aggregation, and thrombus formation) is tigh...

摘要：ABSTRACTUnderstanding the increasingly complex role of chemokines in various manifestations of atherosclerotic vascular disease and the apparent redundancy in their expression requires improved con...

摘要：For example, both angiotensin II (Ang II) and insulin are known to mediate protein tyrosine phosphorylation and dephosphorylation events。 These apparently paradoxical effects of Ang II and insulin...

摘要：The Id family of helix-loop-helix (HLH) transcription factors has emerged as important regulators of cellular growth and differentiation。 Recent published findings have implicated the Id proteins ...

摘要：ABSTRACTObjective— Endothelial progenitor cells (EPCs) display a unique aptitude to promote angiogenesis and restore endothelial function of injured vessels。 We hypothesized that EPCs are resista...

摘要：From the Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute (R。S。, A。H。, E。J。, T。W。, S。R。T。, J。F。K。), Boston University School of Medicine, Mass。 the Centre ...

摘要：4,5Hypercholesterolemia is one of the most important coronary risk factors。Aortic Pressure, Blood pH, and Blood Gas Data of Dogs in Control and Hypercholesterolemia GroupFigure 1A shows the detect...

摘要：ABSTRACTObjective— Macrophage-mediated oxidation of low-density lipoprotein (LDL) by enzymes, such as the lipoxygenases, is considered of major importance for the formation of oxidized LDL during ...

摘要：ABSTRACTObjective— Inhibition of 3hydroxy3methylglutaryl–coenzyme A (HMG-CoA) reductase by statins and the subsequent reduction in Rho protein isoprenylation inactivates these important signaling...

摘要：Statins reduce plasma levels of low-density lipoprotein (LDL) and are effective treatments for atherosclerosis。 Lovastatin, simvastatin, and zaragozic acid, a squalene synthase inhibitor, blocked ...

摘要：ABSTRACTBackground— Programmed death-1 (PD-1), a member of the CD28 family, has been identified。 PD-1 is involved in the negative regulation of some immune responses。Programmed death 1 (PD-1) is...

摘要：Preparation of Anti-Rat E-Selectin MAbAnti-rat E-selectin mAbs were generated by immunizing female BALB/c mice by footpad injection of 2 to 5x106 rat E-selectin–expressing Chinese hamster ovary (E...

摘要：ABSTRACTObjective— To determine the role of the cardiovascular-restricted, hairy-related bHLH transcription factor, CHF1/Hey2, in the biological response to vascular injury。Methods and Results— ...

摘要：Carvedilol inhibited TNF-–stimulated endothelial vascular cell adhesion molecule-1 (VCAM-1) and E-selectin (66。Conclusions— Carvedilol reduced TNF-–stimulated endothelial adhesiveness to human ...

摘要：NCX 4016 Blunts Aspirin-Induced Downregulation of VEGF-A ExpressionFinally, we evaluated the effect of treatments on the expression of angiogenic factors。 Nitric oxide donors and cardiovascular ag...

摘要：Asynchronous hemodynamic circumferential strain and wall shear stress occur in pathologic regions。 Asynchronous mechanical force patterns (SPA=–180°) can elicit proatherogenic responses in endot...

摘要：ABSTRACTObjective— We investigated the regulation of p38 mitogen-activated protein kinase (MAPK) by platelet-derived growth factor (PDGF)-BB and its biological effects in cultured normal and diabe...

摘要：Accordingly, we investigated the hypothesis that systemic injection of SHh protein could improve nerve blood flow and function in diabetic neuropathy (DN)。Methods and Results— Twelve weeks after ...

摘要：endotheliumIntroductionEndothelial cell interactions with the surrounding extracellular matrix (ECM) are mediated primarily by the integrin family of adhesion receptors。1 Endothelial cells have be...

摘要：Monocyte chemoattractant protein-1 (MCP-1) controls monocyte-mediated inflammation through its receptor, CCR2。21 Bone marrow cells were harvested from femurs and tibias of either test (apoE–/–CC...

摘要：Gender-related differences in aneurysms may be estrogen-mediated via reductions in macrophage MMP-9。 Aortic diameters were then measured at the level of the left renal vein, the mid-infrarenal aor...

摘要：transgenic mouse modelsIntroductionVascular remodeling, defined as a lasting change in the diameter of a mature blood vessel, requires coordinated degradation and deposition of extracellular matrix...

摘要：2,3 Enzymatically-remodeled LDL (E-LDL) binds C-reactive protein (CRP) and activates complement。Isolation and Modification of LDLLDL from healthy subjects, aged 18 to 65 years, was isolated by pre...

摘要：TNF-IntroductionTumor necrosis factor- (TNF-) participates in the direction of the inflammatory response and influences the balance of blood lipid composition。 Tumor necrosis, cachexia, shock, and...

摘要：ABSTRACTObjective— We evaluated the role of angiotensin II (AII) in a marrow-derived macrophage-driven model of atherosclerosis。Methods and Results— Eight-week-old C57BL/6 wild-type mice were re...

摘要：and the Medical Genetics Institute (J。 Gene expression profiling represents a powerful tool for the identification of genes involved in complex diseases。The microarray platform used was Genechip ...

摘要：From the Department of Cell Biology NC10, Cleveland Clinic Foundation, Cleveland, Ohio。ABSTRACTObjective— ABCA1 mediates cellular cholesterol and phospholipid efflux to apolipoprotein A-I and oth...

摘要：Lipoprotein EffluxThe efflux of lipoproteins represents the number of lipoprotein particles that migrated from each region of arterial tissue as shown in Figure 4。 Cm-rm (50 nm) Efflux indicates c...

摘要：ABSTRACTBackground— Inflammation variables (C-reactive protein , fibrinogen, and soluble intercellular adhesion molecule-1 ) have been identified as risk factors for cardiovascular disease。 Genet...

摘要：Incubation of Isolated LDLs With MacrophagesPermanent mouse RAW264。17,34,35 Macrophage activation was significantly and directly associated with several LDL parameters and parameters connected to ...

摘要：ABSTRACTObjective— High-density lipoprotein (HDL) is a heterogeneous lipoprotein class and there is no consensus on the value of HDL subspecies in coronary heart disease (CHD) risk assessment。 We...

摘要：Nat Genet。

摘要：Effects of ApoB Genotypes on Plasma Lipids and ApolipoproteinsTable 1 shows data for plasma lipid and apolipoprotein concentrations for the 3 apoB genotypes。 Plasma Levels of Lipids and Apolipopro...

摘要：Leptin administration promotes arterial thrombosis in mice, and leptin-deficient ob/ob mice have an attenuated thrombotic response to injury。Conclusions— Inhibition of circulating leptin protects...

摘要：Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, MATo the Editor:Moderate consumption of red wine is associated with a reduction in ...

摘要：1 Collagen signals generated at a site of arterial vessel injury are therefore likely to be among the first platelet activating signals that generate the coronary thrombi responsible for myocardial...

摘要：Distribution of Heterozygote and Homozygote for TSP-4 387P Genotypes Among MI Patients With Different Onset Ages, Genders, and Compared With Age and Gender Matched Normal Controls (NC)The 387P alle...

摘要：Mouse model of venous bypass graft arteriosclerosis。Mouse Models of Vein GraftsMasataka Sata。 Mouse model of venous bypass graft arteriosclerosis。 Mouse models of arteriosclerosis: from arterial...