摘要：During bone formation, the major orthotopic venue, two general mechanisms drive tissue mineralization1 (Table)。 this cartilage template calcifies and is subsequently resorbed and replaced by bone ...

摘要：If the course of atherosclerotic disease were an opera, fatty streak formation would be the Preludio。Thanks to the study by Tenger et al we now know that, if IL-18 conducts, the Preludio sounds th...

摘要：Leukocytosis also is associated with poor prognosis and vaso-occlusive events in patients with sickle cell disease, and experimental data suggest a direct role for leukocytes in microvascular obstr...

摘要：GriendlingRedox Mechanisms in Blood VesselsATVB In FocusPrevious Brief Review in this Series:。 Redox mechanisms in blood vessels。 Redox Modulation of KCa ActivityWhen considering oxidative modula...

摘要：edu AbstractCyclooxygenase-2 (COX-2) is a highly inducible enzyme exerting diverse actions on cell functions, including proliferation, migration, and DNA damage。 Enhanced COX-2 expression may be p...

摘要：NPP1 hydrolyzes ATP to generate PPi, a physicochemical inhibitor of hydroxyapatite crystal growth。 Because ectopic chondro-osseous differentiation promotes artery calcification in atherosclerosis ...

摘要：From Stem Cell Research Institute (D。Correspondence to Roberto Latini, Department of Cardiovacular Research, Stem Cell Research, Istituto Mario Negri, Dibit, H。Mesoangioblasts (Mabs), vessel-asso...

摘要：Impact of Hyperglycemia on the Amount of CPCThe number of CPCs as assessed by DiL–acLDL and FITC lectin staining was decreased by 33% after 7-day culture in hyperglycemic medium compared with osmo...

摘要：de AbstractObjective— Ca2+-activated K+ (KCa) channels have been proposed to promote mitogenesis in several cell types。 Selective IKCa1 blocker might be of therapeutic value to prevent tumor angi...

摘要：com AbstractObjective— 15-Deoxy-12,14-prostaglandin J2 (15d-PGJ2), a natural ligand of the peroxisome proliferator–activated receptor- (PPAR), has been shown to inhibit proinflammatory gene expre...

摘要：Binding of CRP to oxidized LDL did not interfere with binding of annexin A5, and vice versa。 Annexin A5 alone had no effect on binding of oxidized LDL to the cells。 Annexin A5 also binds to oxidi...

摘要：se AbstractObjective— Inflammatory responses of large vein endothelium are of importance in pathological processes such as venous thrombosis, chronic venous congestion, and vein graft atherosclero...

摘要：It is unknown whether these functions can be inhibited by soluble forms of JAM-A, whether JAM-A is expressed on atherosclerotic endothelium, and whether it participates in atherogenic recruitment o...

摘要：Purification of tPA Kringle 2 DomainK2P was incubated with porcine pancreatic elastase in a molar ratio of K2P:elastase of 3。

摘要：Forkhead Transcription Factor Is Phosphorylated Immediately After In Vivo Balloon InjuryFrom the in vitro data, we concluded that the overexpression of FKHRL1 leads to VSMC apoptosis and cell-cycle...

摘要：Neointima formation was assessed by histomorphometric measurement of 4 in-stent neointimal areas with 2 mm distance from each other to assure a comprehensive result reflecting the whole stented seg...

摘要：In Vitro Stent-Based Delivery of Adenovirus to Porcine Coronary ArteriesRAdlacZ was used to confirm effective viral transduction from a stent platform to porcine coronary tissue。In Vivo Stent Deli...

摘要：jp AbstractObjective— Insulin is an antiapoptotic factor of cultured vascular cells, but it is not clear whether it also exerts antiapoptotic effects on vascular cells in vivo。Conclusions— Insul...

摘要：Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice。 Hydrogen peroxide: an endogenous smooth muscle cell hyperpolarizing factor。 Hydrogen peroxide induces endothelium-depen...

摘要：Kinin B1 receptors and the cardiovascular system: regulation of expression and function。 Kinin receptors in human vascular tissue: their role in atheromatous disease。 Receptors for kinins in the ...

摘要：Characteristics of the Study Population Homocysteine Is Inversely but Not Statistically Significantly Associated With FMD and NMDHomocysteine in the highest tertile (12。 Homocysteine, SAM, and 5-M...

摘要：SAA Is Present on Both ApoA-I–Containing and ApoB-Containing Lipoproteins in apoE–/– and LDLR–/– Mouse PlasmaSAA-containing lipoproteins were isolated by immunoprecipitation from plasma of cho...

摘要：se AbstractObjective— The proatherogenic effect of IL-18 is shown to be dependent on IFN- production。 It is believed that activated T cells play a proatherogenic role through secretion of IFN-。 ...

摘要：de AbstractObjectives— Lipoxygenases with different positional specificity have been implicated in atherogenesis, but the precise roles of the various isoforms remain unclear。 Expression of this ...

摘要：20 Lymphocytes have also been implicated in cardiomyocyte injury during autoimmune myocarditis,21–25 and spontaneous RAG2-dependent, lymphocyte-mediated immune responses in mice lacking the negati...

摘要：Inactivity increased vascular lipid peroxidation to 148±9% and upregulated superoxide release to 176±17% (L-012 chemiluminescence) and 188±29% (cytochrome C reduction assay), respectively。 Inac...

摘要：fi AbstractBackground— Advanced glycation end products (AGEs), modification products of glycation or glycoxidation of proteins and lipids, have been linked to premature atherosclerosis in patients...

摘要：Ischemic CVD was defined as patients with an acute or sudden focal neurological defect lasting for 24 hours and positive brain image lesions by computed tomography, magnetic resonance imaging, or m...

摘要：fi AbstractObjective— Chronic Chlamydia pneumoniae (Cpn), Helicobacter pylori (Hp), and herpes virus infections have been associated with atherogenic serum lipid profile and an excess of cardiovas...

摘要：), University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki。Correspondence to Pirkko Pussinen, Institute of Dentistry, University o...

摘要：uk AbstractObjectives— To study the prospective relationship between serum levels of type II secretory phospholipase A2 (sPLA2) and the risk of future coronary artery disease (CAD) in apparently h...

摘要：Methods and Results— Of the genotypes tested, only homozygosity for the rare CX3CR1 alleles was more frequent in cases than in controls: the I249 and M280 alleles were associated with an increased...

摘要：Human scavenger receptor class B type 1 (SR-BI。 Human scavenger receptor class B type 1 plays a central role in HDL-mediated cholesteryl ester hydroperoxides uptake。 Scavenger receptor BI mediate...

摘要：edu AbstractObjective— Previous work has shown that platelets stimulated with the combination of thrombin and convulxin, a glycoprotein VI agonist, develop 2 populations with different levels of -...

摘要：The Effects of oxLDL on AggregationnLDL-induced p38MAPK phosphorylation is an early and rapid step in a slow process that after 5 minutes or more synergistically increases agonist-induced fibrinoge...

摘要：Catherine De Angelis, MD, MPH, Editor-in-Chief, Journal of the American Medical Association。 Drazen, MD, Editor-in-Chief, New England Journal of Medicine。 Charlotte Haug, MD, PhD, MSc, Editor-in-...

摘要：PessinaDepartment of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, ItalyTo the Editor:In a recent article, Wolfrum et al1 have shown that in human cells in culture, in...

摘要：1 They investigated IL-1。 Moreover, they demonstrated mononuclear cells with TT homozygote to show decreased IL-1。 We previously investigated IL-1。 (–511C/T) and IL-1Ra (a variable number repea...

摘要：IV Divisione di Clinica Medica, Department of Experimental Medicine and Pathology, University of Rome “La Sapienza“, ItalyTo the Editor:Oxidative stress is believed to play a major role in the in...