摘要：IL-6 exerts its effect through Signal Transducer and Activator of Transcription 3 (STAT3) that interacts with the PROS1 promoter at a binding site in between nucleotides 229 to 207 upstream from th...

摘要：In Vitro -Tocopherol Loading of ErythrocytesFreshly isolated erythrocytes from WT mice were incubated for 3 hours at 37°。- and -Tocopherol Quantitation in Isolated Lipoproteins and Erythrocytes...

摘要：20 MegaBecquerel drawn-up from a 99m Tc generator, freshly eluted) with stannous tricine in a sterile vial containing annexin V (Theseus Imaging Corp)。ANX Uptake in the Luminal Part of the Aneury...

摘要：Chemokines like monocyte chemoattractant protein-1 (MCP-1/CCL2), interleukin-8 (IL-8/CXCL8), and INF- -inducible protein-10 (IP-10/CXCL10) are expressed in atherosclerotic lesions。 Correlation of ...

摘要：Endothelial progenitor cells (EPCs) have been implicated in adult neovasculogenesis and maintenance of endothelial homeostasis。 2Endothelial progenitor cells (EPCs) are a subtype of bone marrow-de...

摘要：Ubiquitin-Proteasome SystemImmunoblotting for Ubiquitin and Ubiquitin ConjugatesThe expression of free (8。

摘要：The Serine/Threonine Kinase Phosphorylation AssayPI3K-mediated phosphorylation of the serine/threonine kinase (Akt) was determined by immunoblotting using anti-pAkt S473 (1:750 dilution。ResultsPI3...

摘要：【摘要】 Objective- Osteoprotegerin (OPG), a member of the tumor necrosis factor (TNF) superfamily of proteins, plays an important role in bone remodeling and is expressed in both mouse and hu...

摘要：) and Laboratory of Microtomography (A。

摘要：ß。Methods and Results- Expression of ß。 In a third group of rabbits, nontargeted fumagillin nanoparticles did not alter vascular ß。ß。

摘要：【摘要】 Objective- Cardiolipin (CL) is found in membranes of bacteria, in the inner membrane of mitochondria and in plasma low-density lipoprotein (LDL)。 1-4 Cardiolipin is a phospholipid (P...

摘要：【摘要】 Objective- Atherosclerosis is a chronic inflammatory disease with immune cell infiltration。 Interleukin-20 (IL-20) belongs to the IL-10 family and is a proinflammatory cytokine invol...

摘要：ResultsMyocardial Infarction Augments Neointimal Hyperplasia in Injured ArteriesFour weeks after the surgery, neointima formation was observed in mice in both the AMI+VI and VI groups ( Figure 1A a...

摘要：Induction of EC DifferentiationInduction of VEGFR-2 + cells and sorting for VEGFR-2 + cells were performed as described previously 19 ( Figure 1 A)。 Differentiation of ECs from ES cells。 Cells we...

摘要：Aneurysm rupture was historically considered to be a simple physical process that occurred when wall stress from the circulation exceeded the tensile strength of the aortic wall。

摘要：Gene-Transfer by ElectroporationGene-transfer of 7ND-MCP-1 was performed one day before vein graft surgery by injecting 75 µ。Inhibition of Endogenous MCP-1 Receptor by 7ND-MCP-1 Inhibits Vein...

摘要：【摘要】 Objective- A functional polymorphism in the chemokine receptor CX 3 CR1 is associated with protection from vascular diseases including coronary artery disease and internal carotid art...

摘要：【关键词】 angiotensin II cAMP response element binding protein thyroid hormone vascular remodeling IntroductionThyroid hormone has various effects on the cardiovascular system。 (n=6)CREB Inter...

摘要：ResultsEffect of Sphingosine Kinase Inhibition on Vascular ContractionIn the contraction experiments, the mean normalized diameter of a total number of 82 carotid artery preparations was 1028&plusm...

摘要：26,27Role of L-Arginine and Arginase in Vascular DysfunctionTo determine whether the deficiency of L-arginine contributes to the impaired NO-mediated response, the adenosine-induced and ionomycin-i...

摘要：11 Vascular smooth muscle apoptosis occurs throughout atherogenesis, but is accentuated in advanced lesions because of the heightened inflammatory and pro-oxidant micro-environment of the plaque。 ...

摘要：To design a novel angiogenic factor without severe side effects, we examined the biological function of chimeric VEGF-E NZ7 /placental growth factor (PlGF), which is composed of Orf-Virus NZ7 -deri...

摘要：【摘要】 Objective- HSPA12B is the newest member of HSP70 family of proteins and is enriched in atherosclerotic lesions。 This study focused on HSPA12B expression in mice and its involvement i...

摘要：【摘要】 Objective- We have previously shown that JAM-A regulates fibroblast growth factor-2 (FGF-2)-induced endothelial cell morphology, proliferation, and migration。 Whether JAM-A is involv...

摘要：【摘要】 Objective- Tissue regeneration requires both growth factor and extracellular matrix such as collagen, serving as a scaffold for cell growth。 We established FNCBD-VEGF121, consisting ...

摘要：IQGAP1 is a novel VEGFR2 binding protein, and it interacts directly with actin, cadherin, and ß。Methods and Results- Confocal microscopy analysis shows that IQGAP1 colocalizes with VE-cadheri...

摘要：【摘要】 Objective- Extracellular superoxide dismutase (EC-SOD) is a secreted antioxidant enzyme that binds to the outer plasma membrane and extracellular matrix through its heparin-binding do...

摘要：Addition of 8bromo-cAMP or adrenomedullin (AM), an endogenous ligand-elevating cAMP, enhanced VEGF-induced EC differentiation。 Whereas VEGF alone mainly induced venous ECs, 8bromo-cAMP (or AM) wit...

摘要：Endothelial Transport PropertiesCerebral capillaries strictly limit transport of solutes, proteins, and chemical agents in the circulation into the neuropil。Specialization of the MicrovasculatureR...

摘要：Dietary sufficiency recommendations were followed by recommendations to reduce cholesterol levels and the risk for cardiovascular disease。Dietary recommendations for carbohydrate intake have evolv...

摘要：【摘要】 Atherogenesis is the pathobiological process, which underlies atherosclerotic cardiovascular disease and evolves in the 3 stages of initiation, progression, and complication to clinic...

摘要：【摘要】 Angiogenesis, the process by which new blood vessels develop from a pre-existing vascular network, is essential for normal development and in certain physiological states。 Inadequate...