摘要：Hepatocyte growth factor increased PAI-1 mRNA expression and protein in highly differentiated human liver-derived HepG2 cells, and increased hepatic PAI-1 mRNA expression in vivo in mice。 2Hepatoc...

摘要：Induction of surface expression and intracellular accumulation of TF antigen in MNCs from rats after rewarming from hypothermia。The Induction of TF Transcription After Rewarming From Hypothermia W...

摘要：【摘要】 Objective- The objective of this study is to delineate the molecular mechanisms responsible for Staphylococcus aureus -platelet adhesion as a function of physiologically relevant wall...

摘要：Close approximation of PF4 is unlikely to occur in vivo in the absence of polyanions, due to the strong electrostatic repulsion (zeta potential) of the positively charged PF4 tetramers。 Platelet f...

摘要：Conclusions- Carotid IT is associated with smoking, whereas age and hypertension are associated with thickness of all 3 arterial layers。 【关键词】 carotid arteries atherosclerosis risk ...

摘要：Twin Research and Genetic Epidemiology Unit (R。

摘要：Quantification of fibrous tissue has not been done previously with MDCT。 Quantification of coronary artery calcium using ultrafast computed tomography。

摘要：Generation and Purification of Polyclonal AlloantibodiesPolyclonal anti-BN alloantibodies were generated by the skin graft method。Production of Growth Factors by SMCs Incubated With Alloantibodies...

摘要：【摘要】 Background- Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) play a central role in arterial wall remodeling, affecting stability of fibrous caps covering atherosclerotic...

摘要：Serum levels of total cholesterol, high-density lipoprotein cholesterol (HDL-c), and triglycerides were measured on fresh samples with the RA 1000 (Bayer Diagnostics, Basingstoke, UK), and low-dens...

摘要：【摘要】 Objective- Granulocyte-macrophage colony-stimulating factor (GM-CSF) is expressed in atherosclerotic lesions but its significance for lesion development is unknown。 Consequently, we ...

摘要：【摘要】 Objective- In mice that are heterozygous for mitochondrial superoxide dismutase (SOD2 +/- ) with apoE deficiency (apoE -/- ), mitochondrial DNA damage increases formation of atheroscl...

摘要：【摘要】 Objective- Based on the observation that Fxr -/- mice exhibit a proatherogenic lipoprotein profile, we investigated the role of FXR in the development of atherosclerosis。Conclusions-...

摘要：Conclusion- Fenofibrate reduces atherosclerosis more than can be explained by lowering total plasma cholesterol per se。ResultsFenofibrate Reduces Plasma Lipids in E3L MiceThe food intake was on av...

摘要：Plasma Cholesterol, Triglyceride, and Lipoprotein MeasurementsBlood samples were collected by retro-orbital venous plexus puncture after a 5- to 6-hour fast。ResultsAtherosclerosis Studies in Ldlr ...

摘要：【摘要】 Objective- The lungs of Abcg1 -/- mice accumulate macrophage foam cells that contain high levels of unesterified and esterified cholesterol, consistent with a role for ABCG1 in facili...

摘要：【摘要】 Objective- ABCG1 has recently been identified as a facilitator of cellular cholesterol and phospholipid efflux to high-density lipoprotein (HDL)。 The role of macrophage ABCG1 in athe...

摘要：In this study, we investigated expression and function of the NR4A nuclear receptor family, comprising Nur77 (NR4A1, TR3), Nurr1 (NR4A2), and NOR-1 (NR4A3) in human macrophages。Methods and Results...

摘要：57,58 Microcirculatory involvement is well recognized in SLE, 59,60 and this technique may provide information useful in assessing disease activity and response to treatment and ultimately in predi...

摘要：Oral Glucose Tolerance TestOGTT was performed in the RD group (before randomization), the AL group, and Wistar rats at the age of 10 weeks (n=5, respectively)。 Blood samples were taken from the ta...

摘要：【摘要】 Objectives- The major immediate-early cytomegalovirus enhancer/promoter (MIECMV), widely used in cardiovascular gene therapy, contains several positively regulatory cAMP response elem...

摘要：Antibodies to HK receptors on leukocytes including Mac-1, LFA-1, uPAR, and C1qR inhibited IL-1ß。 from human monocytes using intracellular signaling pathways initiated by uPAR, ß。2 integ...

摘要：Methods and Results- In the human and murine CNV tissues, the vascular endothelium expressed angiotensin II type 1 receptor (AT1-R), AT2-R, and angiotensin II。We analyzed the involvement of the re...

摘要：【摘要】 Background- Embryonic stem cells possess the ability to differentiate into endothelium。 The ability to produce large volumes of endothelium from embryonic stem cells could provide a ...

摘要：Granulocyte colony-stimulating factor (G-CSF) is well-established to mobilize hematopoietic stem cells (HSCs) and might, thereby, also increase the pool of endogenously circulating EPC。 Granulocyt...

摘要：14-16Caldesmon (CaD) is one of the proteins that regulate the actin cytoskeleton。 25Cell Proliferation Assay and Apoptosis AssayVSMCs (1 x 10 4 cells/100 µ。 27Migration AssayThe migration as...

摘要：T-cad Ligation on ECs Stimulates Angiogenesis in the Spheroid In Vitro ModelThe 2-dimensional models for cord-forming have been successfully used for studying effects of cell matrix interactions on...

摘要：Vascular Cell CocultureVascular cell cocultures were made according to methods previously described。Vascular Smooth Muscle CellsSimilar to that seen in EC, the changes in Cx37 expression in VSMC w...

摘要：Effect of High-Fat Diet With or Without PAI-039 on Body Weight, Epididymal Adipose Tissue Morphology, and Plasma PAI-1TABLE 2。 Adipose tissue secretion of plasminogen activator inhibitor-1 in non-...

摘要：【摘要】 The link between plasminogen activator inhibitor (PAI)-1 and the metabolic syndrome with obesity was established many years ago。 Increased PAI-1 level can be now considered a true co...

摘要：Estrogen Receptors at WorkThe biological actions of estrogen are largely mediated by 2 distinct ER isoforms, namely ER and ERß。 Estrogen receptors at work in the cardiovascular system。Select...