摘要：Fibrin of young CAD patients was stiffer ( P =0。 Fibrin stiffness was an independent predictor for both premature CAD and hypofibrinolysis。 Fibrin porosity was determined by measuring the fiber-f...

摘要：【摘要】 Objective- We investigated whether the dual PPAR / agonist tesaglitazar has anti-atherogenic effects in ApoE*3Leiden mice with reduced insulin sensitivity。Methods and Results- ApoE*3...

摘要：Protein bands were stained with Coomassie Brilliant Blue R250 (Sigma), and apparent molecular masses were identified。CETP Activity and Protein LevelsCETP activity in plasma was measured as the tra...

摘要：【摘要】 Objective- Delayed blood pressure (BP) recovery after psychological stress is associated with low socioeconomic status (SES) and prospectively with increases in clinic BP。 We tested ...

摘要：Obese children had significantly higher levels of hsCRP, hsIL-6, and E-selectin than healthy controls (4。 Obese children had lower peak FMD response (7。 23Obese children were recruited from the o...

摘要：Median (Interquartile Range) Plasma Concentrations of Asymmetric Dimethylarginine (ADMA) Grouped According to Categorical Baseline VariablesTABLE 2。 Spearman Correlation Coefficients for Asymmetri...

摘要：【摘要】 Objectives- Atherosclerosis may be caused by increased endothelial damage and by a consumptive loss of endothelial repair capacity by endothelial progenitors。 Arterial stiffness is a...

摘要：Apoptosis and Lp-PLA 2 ExpressionColocalization of apoptosis in cells expressing Lp-PLA 2 was assessed by combined ISEL and immunohistochemistry。 Morphometric Assessment of Vessel Area, Stenosis, ...

摘要：After adjustment for age and sex, the hazard ratios for death in the middle and upper Lp-PLA 2 tertiles were 2。 After adjustment for age and sex, the HR (95% CI) for death were 2。 Area Under the ...

摘要：Phospholipase A2 and small, dense low-density lipoprotein。

摘要：We have previously found that macrophages in atherosclerotic lesions secrete lysosomal hydrolases that can modify low-density-lipoprotein (LDL) in vitro to generate hydrolase-modified LDL (H-LDL)。...

摘要：【摘要】 Objective- Advanced glycation end products (AGEs), such as N -(carboxymethyl)lysine (CML), are implicated in vascular disease。 We previously reported increased CML accumulation in sm...

摘要：Nuclear Protein Extraction and ImmunoblottingNuclear protein extracts and immunoblotting were performed using standard procedures。 Importantly, in cells treated with oxPAPC, the disruption of XBP1...

摘要：【摘要】 Objective- Monocyte chemoattractant protein-1 (MCP-1) is a C-C chemokine that is known as an inflammatory/arteriogenic factor。Methods and Results- Using murine models of fibroblast g...

摘要：CRP Alters the Expression of Antioxidative Enzymes in EPCs in a Manner That Promotes ROS ProductionPreviously, it was shown that EPCs have greater levels of antioxidative enzyme expression (compare...

摘要：【摘要】 Objective- C-Reactive protein (CRP), a cardiovascular risk marker, could also participate in atherosclerosis。 Atherosclerotic plaques express CRP and interleukin (IL)-10, a major ant...

摘要：【摘要】 Objective- Proliferation of smooth muscle cells is implicated in cardiovascular complications。 Previously, a urea-based soluble epoxide hydrolase inhibitor was shown to attenuate smo...

摘要：OxLDL increased the S -glutathiolation of p21ras, and adenoviral transfection with either a mutant p21ras (C118S) lacking the predominant site of S -glutathiolation or a dominant-negative mutant re...

摘要：【摘要】 The coagulation and fibrinolytic systems safeguard the patency of the vasculature and surrounding tissue。 Cross regulation of coagulation and fibrinolysis plays an important role in ...

摘要：【摘要】 Tetrahydrobiopterin (BH 4 ) is an essential cofactor for the aromatic amino acid hydroxylases, which are essential in the formation of neurotransmitters, and for nitric oxide synthase...

摘要：【摘要】 Niemann-Pick C1-like 1 protein (NPC1L1) was recently shown to be the molecular target of the cholesterol absorption inhibitor class of drugs, of which ezetimibe is the first widely us...

摘要：【摘要】 The idea that atherosclerosis is an inflammatory disease is no longer controversial。 Adaptive immunity, in particular T cells, is highly involved in atherogenesis。 It is well known ...