摘要：【摘要】 Objective- The purpose of this study is to investigate the expression and regulation of type-2 tissue factor pathway inhibitor (TFPI-2) in endothelial cells, as well as the regulation...

摘要：【摘要】 Objective- Platelet activation significantly contributes to cardiovascular morbidity and mortality in diabetes。 An association between impaired NO-mediated platelet inhibition and pl...

摘要：【摘要】 Background- Joint exposure to oral conjugated equine estrogen (CEE) and prothrombotic genetic variants factor II G20210A or factor V G1601A (Leiden) increase venous thrombotic risk 6-...

摘要：【摘要】 Objective- We investigated in patients with ongoing myocardial infarction (MI) whether coagulation factor VII (FVII) and tissue factor (TF) levels are affected at admission by genetic...

摘要：ResultsBaseline Characteristics of Individuals According to Cardiovascular Outcome During Follow-UpOf the 1068 patients enrolled in the study, 1057 (99%) were followed up during a median interval o...

摘要：Methods and Results- Melagatran (500 µ。 Melagatran had no significant effect on early lesion formation in C57BL/6J mice。 Melagatran attenuated lesion progression and promoted plaque stabilit...

摘要：Relationship of atherosclerosis in young men to serum lipoprotein cholesterol concentrations and smoking。

摘要：Circulating leukocyte-derived microparticles (MP) were related to Framingham risk, metabolic syndrome, CRP, and presence and extent of preclinical atherosclerosis in 216 primary prevention subjects...

摘要：【摘要】 Objectives- Atherosclerotic coronary artery calcification (CAC) is associated with increased coronary heart disease (CHD) risk。 Matrix Gla protein (MGP) is an inhibitor of calcificat...

摘要：Because the myeloid IgA Fc receptor encoded by FCAR mediates inflammation, we hypothesized that the FCA R Asp92Asn polymorphism is associated with risk of MI and that this risk would be modified by...

摘要：Methods and Results- Plasma adiponectin levels were measured in 373 men and 514 women of middle-age by a time-resolved immunofluorometric assay。Conclusion- Plasma adiponectin is a marker of glucos...

摘要：Postprandial hypertriglyceridemic (PHT) rabbit shows hyperinsulinemia, glucose intolerance, and central obesity。 Rabbits were fed a standard diet (120 g per rabbit per day。Comparison of Morpholog...

摘要：Methods and Results- Concentrations of IL-18 were measured in 382 case subjects with incident CHD and 1980 noncases。

摘要：【摘要】 Objective- Inflammatory markers are associated with vascular disease。 however, variation in the acute phase response (APR) has not been evaluated。 We evaluated whether the APR magni...

摘要：【摘要】 Objective- The activity of the antitumoral agent bexarotene (Targretin, Bexarotene) depends on its binding to the nuclear retinoid-X receptor (RXR) and subsequent transcriptional regu...

摘要：【摘要】 Objective- High-density lipoprotein (HDL) plays a key role in protection against development of atherosclerosis by reducing inflammation, protecting against LDL oxidation, and promoti...

摘要：RAGE Suppression by Simvastatin Is a Glucose-Independent PhenomenonWestern blot analysis confirmed RAGE expression in plaques ( Figure 2 B), markedly higher in diabetic plaques treated with diet al...

摘要：【摘要】 Objective- In vitro studies implicate that the low-density lipoprotein receptor (LDLR)-related protein (LRP) in macrophages has a pro-atherogenic potential。 In the present study, we ...

摘要：【摘要】 Objective- Lysophosphatidylcholine is a major product of low-density lipoprotein (LDL) oxidation and secretory phospholipase A 2 -mediated lipid hydrolysis within atherosclerotic lesi...

摘要：【摘要】 Objective- Recent studies of bone marrow (BM)-transplanted apoE knockout (apoE -/- ) mice have concluded that a substantial fraction of smooth muscle cells (SMCs) in atherosclerosis a...

摘要：Endothelial nitric oxide synthase (eNOS) uncoupling is observed in cardiovascular diseases, but its mechanisms remain elusive。Assay of Nitric Oxide Synthase ActivityThe NO synthesizing activity of...

摘要：【摘要】 Objective- Previously, the peptide sequence cNGR has been shown to home specifically to CD13/APN (aminopeptidase N) on tumor endothelium。 Here, we investigated the feasibility of sel...

摘要：Vascular endothelial growth factor-A (VEGF) is a key regulator for leakiness of blood vessels and it has been reported that VEGF-mediated hyperpermeability was suppressed by angiopoietin-1 (Ang1)。...

摘要：15Nitric oxide (NO) has diverse functions including vasodilator, neurotransmitter and anti-thrombotic activities。 Nitric Oxide。 Nitric oxide decreases stability of mRNAs encoding soluble guanylat...

摘要：Inducible costimulator (ICOS) is a major costimulator of T cell activation。 Inducible costimulator (ICOS) is a member of the CD28/CTLA4 family and is expressed on T cells after activation。

摘要：Inhibitors of HDAC, PI3K, and GATA, but not MEK1/2, inhibit TNF- -mediated induction of monocyte adhesion to HUVECs。 Histone deacetylases (HDACs): characterization of the classical HDAC family。 H...

摘要：【摘要】 Objective- Growth factor- and reactive oxygen species (ROS)-induced activation of VSMCs is involved in vascular disease。 This study investigates whether inhibitory oxidation of prote...

摘要：LPS treatment enhanced protein levels of p22 phox, a catalytic subunit of NADPH oxidase, and increased NADPH oxidase activity and levels of superoxide radicals and hydrogen peroxide。 Furthermore, ...

摘要：ResultsLPS Induces TLR4 mRNA and Protein Expression in HASMCsTotal RNA was extracted and reverse transcribed for PCR from HASMCs after stimulation with 25 ng/mL LPS for 0。

摘要：TLR4 mRNAs often contain AU-rich elements (AREs) in their 3‘ untranslated regions (3‘UTR) which have a high affinity for RNA-binding proteins。 It is not know whether the RNA-binding protein, hum...

摘要：- ), couples myocardial oxygen consumption to coronary blood flow。- and H 2 O 2 production by isolated cardiac myocytes, determined the role of mitochondrial electron transport in the production o...

摘要：【摘要】 Abdominal aortic aneurysm (AAA) affects approximately 5% of elderly men and is responsible for a significant number of deaths in Western Countries。 In this review we examine the risk...

摘要：【摘要】 Apoptosis and vascular cell activation are main contributors to the release of procoagulant microparticles (MPs), deleterious partners in atherothrombosis。 Elevated levels of circula...

摘要：19Immunoreceptor Signaling in Platelet Collagen ResponsesThe possibility that the biological roles of canonical, ITAM-activated immunoreceptor signaling and those of noncanonical, integrin-activate...