摘要：【摘要】 Background- Vascular endothelial growth factor-A (VEGF-A) promotes angiogenesis but causes adverse side effects such as edema or tissue inflammation。1-LacZ, phVEGF-A, pVEGF-Echimera#...

摘要：Vascular NOx production was evaluated by NOx concentrations accumulated in culture medium。 Treatment with atorvastatin (10 µ。 Treatment with atorvastatin (10 µ。 Treatment with 10 µ。

摘要：Methods and Results- Coculture of adipocytes and macrophages resulted in the activation of nuclear factor- B (NF- B), a primary regulator of inflammatory responses, in both cell types。 Pharmacolog...

摘要：ResultsExpression Profile of Thiol-Related Genes in Streptozotocin DiabetesAs the first step for investigating the role of thiol related genes in diabetic complications, we performed a targeted pro...

摘要：【摘要】 Background- Leptin is an adipocyte-derived hormone critical for energy homeostasis and implicated in vascular disease processes。 The relevant cellular leptin receptor pools and signa...

摘要：【摘要】 Objective- The role of the nuclear receptor peroxisome-proliferator activated receptor (PPAR)-ß。/ in endothelial cells remains unclear。 Interestingly, the selective PPARß。...

摘要：Expression of fractalkine and its receptor, CX 3 CR1, is elevated in coronary artery disease。Methods and Results- CX 3 CR1 expression was demonstrated in rat aortic endothelial and smooth muscle c...

摘要：【摘要】 Objective- L-homocysteine and/or L-homocystine interact in vivo with albumin and other extracellular proteins by forming mixed-disulfide conjugates。 Because of its extremely rich cys...

摘要：For the regulation of angiogenesis, proangiogenic genes such as VEGFs and angiopoietins are highly conserved, act specifically on endothelial cells, and play a fundamental role。 However, this coun...

摘要：18The Role of PARs in Vascular PhysiologyIn normal arteries, thrombin and trypsin have been reported to induce endothelium-dependent vasorelaxation, 50-55 endothelium-dependent contraction, 56 or d...

摘要：Decreased thrombus formation was observed after blood perfusion over a collagen coated surface at high shear。Mouse models of Bernard-Soulier bleeding disorder were generated by targeting the GP GP...

摘要：Conclusions- Hyperhomocysteinemia and hypercholesterolemia, alone or in combination, produce endothelial dysfunction and increased susceptibility to thrombosis in Apoe-deficient mice。 【...

摘要：Inhibition by ozLDL Is Not Caused by a Direct Ozone Effect or Solely the Presence of LipoproteinSeveral control experiments were necessary to find out whether the inhibition in the presence of ozLD...

摘要：【摘要】 Objective- Plasma apolipoprotein CIII (apoCIII) independently predicts risk for coronary heart disease (CHD)。 We recently reported that apoCIII directly enhances adhesion of human mo...

摘要：【摘要】 Objective- Hepatic VLDL assembly is defective in HepG2 cells, resulting in the secretion of immature triglyceride-poor LDL-sized apoB particles。 We investigated the mechanisms underl...

摘要：Tnfrsf4 (OX40) and Tnfsf4 (OX40 ligand) are members of the tumor necrosis factor (TNF) and TNF receptor family and OX40/OX40L mediated signaling is important in co-activation of T cells and facilit...

摘要：【摘要】 Objective- Overexpression of lipoprotein lipase (LPL) in deendothelialized artery led to profound localized lipid deposition。 In this study the role of LPL in atherogenesis in endoth...

摘要：Conclusions- Macrophage PLTP deficiency causes a significant reduction of apoE secretion from the cells, and this in turn promotes the accumulation of cholesterol in the circulation and accelerates...

摘要：Pioglitazone has been shown to predominantly activate PPAR- and weakly activate PPAR-。 Pioglitazone powder was kindly provided by Takeda Pharmaceuticals North America (Lincolnshire, Ill)。 Resteno...

摘要：【摘要】 Background- Oxidized phospholipids (OxPL) are pro-inflammatory。Oxidized phospholipids (OxPL) are pro-inflammatory。Oxidized lipids, particularly oxidized phospholipids (OxPL), accumu...

摘要：【摘要】 Objectives- Increasing evidence indicates that the Fas/Fas ligand interaction is involved in atherogenesis。 We sought to analyze soluble Fas (sFas) and soluble Fas ligand (sFasL) con...

摘要：【摘要】 Objective- Plasma pentraxin 3 (PTX3) levels are increased in patients with acute myocardial infarction, yet its involvement in unstable angina pectoris (UAP) remains unclear。 Plasma ...

摘要：【摘要】 Objective- We studied by microarray analysis whether symptomatic and asymptomatic carotid plaques from the same patient differ in gene expression and whether the same changes are pres...

摘要：Markers of inflammation and plaque instability: from foam cell to plaque rupture (modified after reference 2 ) *Biomarkers, which are covered in this review。 23 More importantly, the Fragmin and F...

摘要：【摘要】 Objective- We previously reported preliminary data (N=14) demonstrating a significant and positive relationship between forearm vascular function and neuropsychological performance in...

摘要：【摘要】 Objective- Receptor for advanced glycation end-products (RAGE) is involved in diabetic vascular complications。 We have recently shown that plasma endogenously secretory RAGE (esRAGE)...

摘要：21,22Iron DepositionIron deposition in the plaque was identified using Perl。Morphometric Properties of Plaques in Hp 1-1 and Hp 2-2 MiceIncreased Iron Deposition in Hp 2-2 PlaquesOur previous in v...

摘要：【关键词】 biomarkers gamma glutamyl transferase risk factor cardiovascular disease metabolic syndrome mortality IntroductionGamma。 Baseline Participant Characteristics by Sex-Specific GGT Quar...

摘要：Monocyte dysfunction can be mimicked in vitro by challenging monocytes with a range of reactive oxygen species (ROS)。 Monocytes are important sources of growth factors and their migration into are...

摘要：ResultsAging Results in Exhaustion of Simple Little CellsWe have demonstrated previously that administration of unfractionated bone marrow from age-matched WT or young, but not old, apoE -/- mice s...

摘要：ResultsA Cholinergic Component of Growth Factor-Mediated Endothelial Cell MigrationThe effects of nicotine on human microvascular endothelial cell (HMVEC) migration were studied using standard woun...